Patents Assigned to Clemson University Research Foundation
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Patent number: 12252664Abstract: An improved material, preferably a biomaterial, is provided which is the reaction product of S8 and a free fatty acid or free fatty acid-containing material, preferably in the presence of metal. The improved material can be made by a method comprising reacting S8 with a free fatty acid to obtain a FFA/S8 composite and shaping the FFA/S8 composite into a solid form. The solid form of said FFA/S8 is melted to form melted FFA/S8 and the melted FFA/S8 is optionally applied as a coating on a surface, used as an adjacent material to a surface or the FFA/S8 composite itself is shaped thereby forming a device and preferably a medical device.Type: GrantFiled: December 11, 2019Date of Patent: March 18, 2025Assignee: Clemson University Research FoundationInventors: Andrew G. Tennyson, Rhett C. Smith
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Patent number: 12053906Abstract: A method for fabricating a protonic ceramic energy device includes: coating an electrolyte layer on an anode layer; and densifying the electrolyte layer by a rapid laser reactive sintering (RLRS) process on the electrolyte layer and/or the anode layer to form a half-cell comprising a dense electrolyte and a porous anode.Type: GrantFiled: December 30, 2020Date of Patent: August 6, 2024Assignee: Clemson University Research FoundationInventors: Hai Xiao, Jianhua Tong, Fei Peng, Kyle S. Brinkman, Shenglong Mu, Jincheng Lei, Yuzhe Hong, Hua Huang, Rajendra Bordia
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Patent number: 12038382Abstract: Herein are described data acquisition systems and methods applying such systems to determine three-dimensional (3D) diffusion tensors, and simultaneously, to perform 3D structure imaging. Example data acquisition systems can include computing systems in communication with modified light sheet microscopes that are configured for high-speed volumetric imaging to record 3D diffusion processes and high-resolution 3D structural imaging.Type: GrantFiled: July 16, 2021Date of Patent: July 16, 2024Assignee: CLEMSON UNIVERSITY RESEARCH FOUNDATIONInventors: Hai Yao, Tong Ye, Peng Chen, Xun Chen
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Patent number: 11975109Abstract: Methods and delivery agents for treatment of connective tissue that includes elastic fibers are described. Delivery agents are nano- or micro-sized particles that include a biologically active compound useful in treatment of degraded elastic fibers, and an anchoring agent at a surface that binds at or near the area of degraded elastic fibers. The delivery agents may be utilized for targeted delivery of biologically active compounds to degraded elastic fibers so as to maintain and/or regenerate the elastin component of connective tissue, and to prevent further degradation and/or rehabilitate the structural architecture of the connective tissue.Type: GrantFiled: May 18, 2020Date of Patent: May 7, 2024Assignee: CLEMSON UNIVERSITY RESEARCH FOUNDATIONInventors: Naren Vyavahare, Aditi Sinha
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Patent number: 11944098Abstract: Disclosed are methods for selectively controlling or modifying the growth of Poa annus in a turfgrass using a composition comprising an herbicidally-effective amount tebuconazole, or a salt thereof.Type: GrantFiled: August 17, 2022Date of Patent: April 2, 2024Assignees: North Carolina State University, Clemson University Research FoundationInventors: Fred H. Yelverton, Lambert McCarty
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Patent number: 11946872Abstract: A system for monitoring an analyte concentration in liquid is provided. The system includes a coupon comprising an absorbent body with a window through the absorbent body wherein the liquid is maintained in said window by capillary action and surface tension. A reactant is in the absorbent body wherein the reactant is capable of diffusing into the window to react with an analyte in the liquid, or the reactant is able to react with the analyte within the coupon itself, with color-indicating by-products of the reaction diffusing into the window, wherein the analyte is present in an analyte concentration, to form a reactant with a color wherein the color has an intensity which correlates to the analyte concentration. A light source is provided which is capable of passing light into the window wherein the light is attenuated by the color proportional to the analyte concentration to form attenuated light. A detector is provided which is capable measuring an intensity of the attenuated light.Type: GrantFiled: August 8, 2022Date of Patent: April 2, 2024Assignee: Clemson University Research FoundationInventors: Robert A. Latour, George Chumanov, Alexandra Cholewczynski
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Patent number: 11840772Abstract: Hydrothermal methods for the synthesis of bulk crystals of alkaline earth metal stannates are described. Methods can be utilized for growth of large, single crystals of alkaline earth metal stannates including fully cubic BaSnO3 and SrSnO3.Type: GrantFiled: January 26, 2022Date of Patent: December 12, 2023Assignee: Clemson University Research FoundationInventors: Joseph W. Kolis, Rylan J. Terry, Colin D. McMillen
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Patent number: 11835526Abstract: The present invention provides, among other aspects, functionalized chromophoric polymer dots comprising a hydrophobic core and a hydrophilic cap, and bioconjugates thereof. Also provided are improved methods for preparing functionalized chromophoric polymer dots. Methods for in vivo imaging and molecular labeling are also disclosed.Type: GrantFiled: February 15, 2022Date of Patent: December 5, 2023Assignees: University of Washington, Clemson University Research FoundationInventors: Daniel T. Chiu, Changfeng Wu, Jason McNeill, Jiangbo Yu
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Patent number: 11773362Abstract: Bioreactors and components of bioreactors are described as may be beneficially utilized in development and conditioning of cellular materials for study or implant. The bioreactors are modular, and components of the bioreactors can be easily assembled with alternatives provided to develop specific, predetermined conditioning environments for cellular materials (e.g., implantable tissue). By selection of one of multiple alternative compliance chambers, a bioreactor can be utilized to condition tissue in a low-pressure circuit (e.g., a pulmonary heart circuit), and by utilization of an alternative compliance chamber, the bioreactor can instead condition tissue in a high-pressure circuit (e.g., an aortic heart circuit).Type: GrantFiled: April 29, 2021Date of Patent: October 3, 2023Assignee: Clemson University Research FoundationInventors: Leslie Sierad, Christopher Delaney, Richard Pascal, III, Dan Simionescu, Agneta Simionescu
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Patent number: 11762370Abstract: This system is directed to a computerized system for development of textiles with modified physical properties through stitching and can include a set of non-transitory computer readable instructions configured for: receiving a design pattern representing desired physical properties of a textile having a higher stiffness area and a lower stiffness area; developing a contiguous stitching pattern constrained by a pattern perimeter boundary and having a continuous stitching path, developing a first stiffness area within the contiguous stitching pattern having a first area of density, developing a second stiffness area within the contiguous stitching pattern having a second area of density wherein the first area of density has more stitch density than the second area of density, and transmitting the contiguous stitching pattern to an embroidery machine configured to provide a textile having the contiguous stitching pattern incorporating into the textile.Type: GrantFiled: June 15, 2020Date of Patent: September 19, 2023Assignee: Clemson University Research FoundationInventors: Victor B. Zordan, Ella A Moore, Michael Porter, Ioannis Karamouzas
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Patent number: 11684307Abstract: Implantable sensors for determining bone health that can be utilized in conjunction with orthopedic implants are described. The sensors can include passive strain gauges or passive chemical sensors that can be read by radiographic imaging techniques. Sensors can be affixed to implantable support devices so as to non-invasively monitor the effect of load on the implant; for instance, to provide a quantitative assessment of when a fracture is sufficiently healed to allow safe weight-bearing upon the limb. Alternatively, sensors can monitor the health of a local implant area; for instance, to monitor the implant area of early stage infection or healing of a fusion procedure.Type: GrantFiled: April 23, 2020Date of Patent: June 27, 2023Assignee: Clemson University Research FoundationInventors: Jeffrey Anker, Caleb Behrend, John Desjardins
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Patent number: 11633355Abstract: Provided herein are multi-functional particles. The particles may include poly(lactide-co-glycolide)-g-polyethylenimine (PLGA-g-PEI (PgP)), at least one targeting moiety, at least one therapeutic agent, and/or at least one nucleic acid. Also provided herein are methods of using the multi-functional particles.Type: GrantFiled: February 27, 2019Date of Patent: April 25, 2023Assignee: Clemson University Research FoundationInventor: Jeoung Soo Lee
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Patent number: 11596876Abstract: A relatively fast, inexpensive, and non-destructive method for separation and isolation of biologically active nanoparticles is described. Methods include the use of solid phase separation medis such as channeled fibers in a hydrophobic interaction chromatography (HIC) protocol to isolate biologically active nanoparticles from other components of a mixture. Biologically active nanoparticles can include natural nanoparticles (e.g., exosomes, lysosomes, virus particles) as well as synthetic nanoparticles (liposomes, genetically modified virus particles, etc.Type: GrantFiled: February 5, 2019Date of Patent: March 7, 2023Assignee: Clemson University Research FoundationInventors: R. Kenneth Marcus, Terri F. Bruce, Lei Wang, Sisi Huang, Tyler Y. Slonecki, Rhonda Reigers Powell
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Patent number: 11501472Abstract: This system is designed to color correct a targeted color or colors in a video stream comprising: a computer device having a computer readable medium; and, a set of computer readable instructions embodied on the computer readable medium that are configured to: receive a dataset that includes one or more pairs of video frames where a first frame of the pair of an incorrect color frame and the second frame of the pair is a color correct frame, using a machine learning module to create a mask according to the dataset, receiving an image, correcting the image, and, transmitting the corrected image to a display.Type: GrantFiled: September 27, 2020Date of Patent: November 15, 2022Assignee: Clemson University Research FoundationInventors: Erica B. Walker, D. Hudson Smith
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Patent number: 11452294Abstract: Disclosed are methods for selectively controlling or modifying the growth of Poa annua in a turfgrass using a composition comprising an herbicidally-effective amount tebuconazole, or a salt thereof.Type: GrantFiled: December 6, 2018Date of Patent: September 27, 2022Assignees: North Carolina State University, Clemson University Research FoundationInventors: Fred H. Yelverton, Lambert McCarty
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Patent number: 11433353Abstract: Methods and systems for the separation of hydrogen isotopes from one another are described. Methods include utilization of a hydrogen isotope selective separation membrane that includes a hydrogen isotope selective layer (e.g., graphene) and a hydrogen ion conductive supporting layer. An electronic driving force encourages passage of isotopes selectively across the membrane at an elevated separation temperature to enrich the product in a selected hydrogen isotope.Type: GrantFiled: June 6, 2019Date of Patent: September 6, 2022Assignees: Savannah River Nuclear Solutions, LLC, Clemson University Research Foundation, Georgia Tech Research CorporationInventors: Dale A. Hitchcock, Steven M. Serkiz, Timothy M. Krentz, Josef A. Velten, Kyle S. Brinkman, Eric M. Vogel, Katherine T. Young
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Patent number: 11425863Abstract: Yield monitoring systems for round baling machines and methods that can provide weight estimations for round bales at the time of formation are described. Balers can include those that incorporate hydraulically actuated bale kicking or pushing assemblies as well as those that incorporate spring-loaded off ramps. Farm implements including baling machines and cotton module builders are encompassed. The system includes a sensor that can ascertain a physical parameter associated with ejection of a round bale from the farm implement. Physical parameters as may be ascertained can include pressures, velocities, accelerations, etc. associated with bale ejection.Type: GrantFiled: July 14, 2016Date of Patent: August 30, 2022Assignee: Clemson University Research FoundationInventors: Kendall R. Kirk, H. Guy Ramsey, IV, Perry J. Loftis
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Patent number: 11415523Abstract: A system for monitoring an analyte concentration in liquid is provided. The system includes a coupon comprising an absorbent body with a window through the absorbent body wherein the liquid is maintained in said window by capillary action and surface tension. A reactant is in the absorbent body wherein the reactant is capable of diffusing into the window to react with an analyte in the liquid, or the reactant is able to react with the analyte within the coupon itself, with color-indicating by-products of the reaction diffusing into the window, wherein the analyte is present in an analyte concentration, to form a reactant with a color wherein the color has an intensity which correlates to the analyte concentration. A light source is provided which is capable of passing light into the window wherein the light is attenuated by the color proportional to the analyte concentration to form attenuated light. A detector is provided which is capable measuring an intensity of the attenuated light.Type: GrantFiled: September 4, 2018Date of Patent: August 16, 2022Assignee: Clemson University Research FoundationInventors: Robert A. Latour, George Chumanov, Alexandra Czynski
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Patent number: PP36072Abstract: A new and distinct peach (Prunus persica) cultivar denominated ‘CaroRes Wonder’ can be distinguished by its melting yellow flesh, early ripening season, large size, attractive appearance, high red skin color, excellent fruit quality, good flavor, fruitlet tolerance to late spring frost, and resistance to bacterial spot disease.Type: GrantFiled: July 10, 2023Date of Patent: August 20, 2024Assignee: CLEMSON UNIVERSITY RESEARCH FOUNDATIONInventor: Ksenija Gasic
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Patent number: PP36112Abstract: A new and distinct variety of peach tree (Prunus persica) denominated ‘EveRes Ruby’ can be distinguished by its firm fruit with slow softening, but eventually melting yellow flesh, early to mid ripening season, large size, attractive appearance, high red skin color, excellent fruit quality, good flavor, and fruit resistance to bacterial spot disease.Type: GrantFiled: June 15, 2023Date of Patent: September 17, 2024Assignee: Clemson University Research FoundationInventors: Ksenija Gasic, Ralph Burrell