Patents Assigned to Cleveland Clinic Foundation
  • Patent number: 11490848
    Abstract: Systems and methods for electrocardiographic waveform analysis, data presentation and actionable alert generation are described. Electrocardiographic waveform data can be received from a wearable device associated with a patient. A mathematical analysis of at least a portion of the electrocardiographic waveform data can be performed to provide cardiac analytics. In instances where (1) a pathologically prolonged QT interval and (2) an R on T premature ventricular contraction and/or a ventricular tachycardia are detected from the cardiac analytics of the at least a portion of the electrocardiographic waveform data, an actionable alert can be generated and displayed with a visualization of the cardiac analytics.
    Type: Grant
    Filed: May 20, 2020
    Date of Patent: November 8, 2022
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventor: Daniel J. Cantillon
  • Patent number: 11491350
    Abstract: For decision support in a medical therapy, machine learning provides a machine-learned generator for generating a prediction of outcome for therapy personalized to a patient. The outcome prediction may be used to determine dose. To assist in decision support, a regression analysis of the cohort used for machine training relates the outcome from the machine-learned generator to the dose and an actual control time (e.g., time-to-event). The dose that minimizes side effects while minimizing risk of failure to a time for any given patient is determined from the outcome for that patient and a calibration from the regression analysis.
    Type: Grant
    Filed: September 26, 2019
    Date of Patent: November 8, 2022
    Assignees: Siemens Healthcare GmbH, The Cleveland Clinic Foundation
    Inventors: Bin Lou, Ali Kamen, Nilesh Mistry, Lance Anthony Ladic, Mohamed Abazeed
  • Patent number: 11491333
    Abstract: One aspect of the present disclosure relates to a system for treating obstructive sleep apnea in a subject. The system can include a power source and a neuromuscular stimulator in electrical communications with the power source. The neuromuscular stimulator can include a controller and at least one electrode. The controller can be configured to receive certain power and stimulation parameters associated with a therapy signal from the power source. The at least one electrode can be configured to deliver the therapy signal to a target tissue associated with control of a posterior base of the tongue of the subject.
    Type: Grant
    Filed: January 13, 2021
    Date of Patent: November 8, 2022
    Assignee: The Cleveland Clinic Foundation
    Inventor: Francis A. Papay
  • Patent number: 11491192
    Abstract: A method of treating or preventing overgrowth by pathogenic bacteria in a subject deficient in butyrate and/or butyrate-producing bacteria in their gut microbiota by administering a therapeutically effective amount of a butyrate-producing bacteria to the subject is described. A prebiotic can be included with the butyrate-producing bacteria. Overgrowth by pathogenic bacteria is commonly caused by antibiotic administration.
    Type: Grant
    Filed: January 9, 2019
    Date of Patent: November 8, 2022
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventor: Gail Cresci
  • Patent number: 11484711
    Abstract: This disclosure relates to using stereo-thermo-lesioning (STL) to create lesions at one or more locations in the patient's nervous system at the patient's bedside without general anesthesia. A method that uses STL to treat a patient's neurological condition includes: using a plurality of stereotactically-implanted thermo-coupled multi-contact electrodes to record conduction data within a predetermined theoretical zone of activity within the patient's neurological tissue; detecting abnormal neurological activity of a neurological condition within the conduction data and localize a portion of the predetermined theoretical zone of activity that is responsible for a primary organization of the abnormal neurological activity; creating a lesion at the portion of the predetermined theoretical zone of activity that is responsible for a primary organization of the abnormal neurological activity using at least one contact of the plurality of thermo-coupled multi-contact electrodes.
    Type: Grant
    Filed: July 26, 2017
    Date of Patent: November 1, 2022
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Jorge A. Gonzalez-Martinez, John T. Gale, Andre G. Machado, Imad Najm
  • Patent number: 11471098
    Abstract: Systems and methods are provided for monitoring the effects of therapeutics on the brain. Brains of first and second sets of patients are imaged and a gene expression is measured at a first time to provide a first set of images and a first set of gene expression transcripts. A therapeutic is administered to the first set of patients after the first time. The brains of the patients are imaged and the gene expression of the patients is measured at a second time, after the therapeutic is administered, to provide a second set of images and a second set of gene expression transcripts. A change in the brain is determined for the patients from the sets of images. A set of changes in the gene expression that are correlated with the changes in the brain are determined from the change in the brain and the sets of gene expression transcripts.
    Type: Grant
    Filed: January 22, 2020
    Date of Patent: October 18, 2022
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventor: Amit Anand
  • Patent number: 11475561
    Abstract: Systems and methods are provided for automated identification of acute aortic syndromes in computed tomography images. A region of interest in a chest of a patient is imaged via a computed tomography (CT) scanner to provide images at a plurality of locations. The region of interest includes one of an ascending aorta, an aortic arch, and a descending aorta of the patient. For each of the plurality of locations within the region of interest, a value representing a variation in radiodensity values within the location is determined from the image to provide a set of variation values. A parameter representing a likelihood that the patient is experiencing an acute aortic syndrome is determined via a derived model from the set of variation values. The parameter representing the likelihood that the patient is experiencing the acute aortic syndrome is provided to a user at an associated output device.
    Type: Grant
    Filed: June 19, 2020
    Date of Patent: October 18, 2022
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Paul Schoenhagen, Po-Hao Chen, David Piraino, Nancy Obuchowski
  • Patent number: 11471111
    Abstract: This disclosure relates to a system and method to implement a performance test to help evaluate a patient's neurological and cognitive function. The performance test can be executed by the patient autonomously using a portable computing device, such as a tablet computer or smart phone. The portable computing device can be programmed to execute a set of modules configured to assess motor and cognitive performance, such as a manual function test module, a cognitive processing speed test module, and a movement assessment test module. The set of modules can also include a collection module to aggregate test data from the manual function test module, the cognitive processing speed test module, and the movement assessment test module.
    Type: Grant
    Filed: October 29, 2019
    Date of Patent: October 18, 2022
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Jay L. Alberts, Richard A. Rudick, David D. Schindler, Joshua Hirsch, Stephen M. Rao, Francois Bethoux, Susan Linder, Deborah Miller
  • Patent number: 11471037
    Abstract: Systems and methods are provided for evaluating an eye using retinal fluid volumes to provide a clinical parameter. An optical coherence tomography (OCT) image of an eye of a patient is obtained. The OCT image is segmented to produce a total retinal volume and one or both of a subretinal fluid volume and an intraretinal fluid volume for a region of interest within the eye. A metric is generated as a function of the total retinal volume and one or both of the subretinal fluid volume and the intraretinal fluid volume. A clinical parameter for the patient is determined from the metric. The determined clinical parameter is provided to a user at a display.
    Type: Grant
    Filed: September 12, 2019
    Date of Patent: October 18, 2022
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Justis P. Ehlers, Atsuro Uchida, Sunil Srivastava
  • Publication number: 20220323752
    Abstract: One aspect of the present disclosure relates to a system for treating obstructive sleep apnea in a subject. The system can include a power source and a neuromuscular stimulator in electrical communications with the power source. The neuromuscular stimulator can include a controller and at least one electrode. The controller can be configured to receive certain power and stimulation parameters associated with a therapy signal from the power source. The at least one electrode can be configured to deliver the therapy signal to a target tissue associated with control of a posterior base of the tongue of the subject.
    Type: Application
    Filed: April 26, 2022
    Publication date: October 13, 2022
    Applicant: The Cleveland Clinic Foundation
    Inventor: Francis A. PAPAY
  • Patent number: 11452871
    Abstract: This document discusses, among other things, brain stimulation models, systems, devices, and methods, such as for deep brain stimulation (DBS) or other electrical stimulation. In an example, volumetric imaging data representing an anatomical volume of a brain of a patient can be obtained and transformed to brain atlas data. A patient-specific brain atlas can be created using the inverse of the transformation to map the brain atlas data onto the volumetric imaging data and a volume of influence can be calculated using the patient-specific brain atlas. In certain examples, the volume of influence can include a predicted volume of tissue affected by an electrical stimulation delivered by an electrode at a corresponding at least one candidate electrode target location.
    Type: Grant
    Filed: April 26, 2019
    Date of Patent: September 27, 2022
    Assignee: CLEVELAND CLINIC FOUNDATION
    Inventors: Cameron C. McIntyre, Christopher R. Butson, John D. Hall, Jaimie M. Henderson
  • Patent number: 11446169
    Abstract: A bifurcated implant delivery system is provided for deploying a bifurcated expandable implant in a patient lumen. A shaft has at least two shaft proximal openings. A shaft distal end has at least two shaft branches longitudinally extending from a shaft body distal end. Each of the shaft branches has a shaft open tip. The shaft has at least one shaft lumen that longitudinally extends between a respective shaft proximal opening and at least one respective shaft open tip. A reinforcing element longitudinally extends from the shaft body distal end. An outer sheath has an outer sheath proximal opening and at least one outer sheath open tip. An outer sheath lumen longitudinally extends between the outer sheath proximal opening and the at least one outer sheath open tip. The outer sheath lumen is for selectively holding at least a portion of the shaft and a bifurcated expandable implant therein.
    Type: Grant
    Filed: March 9, 2018
    Date of Patent: September 20, 2022
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventor: Karunakaravel Karuppasamy
  • Publication number: 20220288390
    Abstract: An intra-oral appliance to power and/or communicate with a neurostimulator is provided. The intra-oral appliance can include a teeth covering configured to fit over mandibular incisor, canine and/or premolar teeth of a human being and a remote controller in the form of a housing extending posteriorly from and operably connected to the teeth covering. The housing can include a power source, a coupling coil configured to transmit power to the neurostimulator and configured to receive power from an external charger, and electrical circuitry operably connected to the coupling coil and the power source.
    Type: Application
    Filed: May 31, 2022
    Publication date: September 15, 2022
    Applicants: The Cleveland Clinic Foundation, XII Medical, Inc.
    Inventors: Francis A. PAPAY, Kelly B. EMERTON, Charles P. STEINER, Anthony V. CAPARSO
  • Patent number: 11439690
    Abstract: The invention is directed to a method of treating a spinal cord injury, a neurodegenerative disease or a neuronal injury in an individual in need thereof comprising administering an effective amount of superoxide dismutase (SOD) and catalase to the individual, wherein the superoxide dismutase and the catalase are encapsulated in one or more nanoparticles that release the SOD and catalase upon administration. Another aspect of the invention is directed to compositions comprising superoxide dismutase (SOD) and catalase encapsulated in one or more nanoparticles.
    Type: Grant
    Filed: February 6, 2014
    Date of Patent: September 13, 2022
    Assignee: The Cleveland Clinic Foundation
    Inventors: Vinod Labhasetwar, Hayder H. Jaffer
  • Patent number: 11443422
    Abstract: A system includes a processor and, a computer-readable tangible storage device storing program instructions for execution by the processor. The program instructions include instructions for receiving ultrasonic derived data comprising an ultrasound image, representing a region of interest, and radio frequency “(RF”) data associated with the ultrasound image, and instructions for analyzing the RF data to identify at least one feature associated with a region of interest, including either or both of a feature representing a two-dimensional spectrum feature and a feature based on a cepstrum determined from the RF data. The program instructions further include instructions for classifying the region of interest as one of a plurality of anatomical classes from the identified at least one feature and causing a display to display the anatomical class.
    Type: Grant
    Filed: October 15, 2018
    Date of Patent: September 13, 2022
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Russell J. Fedewa, David Geoffrey Vince, Hesham A. Elsharkawy
  • Publication number: 20220275460
    Abstract: Disclosed are methods of predicting a radiotherapy success in a method of treating a lung cancer of a patient, the use of specific markers for predicting a radiotherapy success in a method of treating a lung cancer of a patient, a database comprising the markers, and a computer program product for use in such a method.
    Type: Application
    Filed: July 31, 2020
    Publication date: September 1, 2022
    Applicants: Siemens Healthcare GmbH, The Cleveland Clinic Foundation
    Inventors: Matthias SIEBERT, Carsten DIETRICH, Heike WEHNER, Jens-Christoph GEORGI, Mohamed ABAZEED, Andreas Emanuel POSCH, Andreas KAPPEL, Mark MATZAS
  • Patent number: 11419533
    Abstract: The present disclosure relates generally to using detected bladder events for the diagnosis of urinary incontinence or the treatment of lower urinary tract dysfunction. A system includes a sensing device comprising a pressure sensor to directly detect a pressure within a bladder. The sensing device is adapted to be located within the bladder. The system also includes a signal processing device to: receive a signal indicating the detected pressure within the bladder; detect a bladder event based the detected pressure within the signal; and characterize the bladder event as a bladder contraction event or a non-contraction event. The characterization of the bladder event can be used in the diagnosis of urinary incontinence or the treatment of lower urinary tract dysfunction.
    Type: Grant
    Filed: March 21, 2019
    Date of Patent: August 23, 2022
    Assignees: THE CLEVELAND CLINIC FOUNDATION, The United States Government as represented by the Department of Veterans Affairs, Case Western Reserve University
    Inventors: Margot S. Damaser, Swarup Bhunia, Robert Karam, Steve Majerus, Dennis Bourbeau, Hui Zhu
  • Patent number: 11413112
    Abstract: A fiber-based radiopaque tissue marker for radiographic marking of tissue is provided. The marker is a sterile, single-patient-use polymeric fiber with a radiopaque material and a dye. The marker is radiopaque using standard radiographs such as x-rays and mammography. The marker can also be visualized by low-dose CT scans.
    Type: Grant
    Filed: October 15, 2018
    Date of Patent: August 16, 2022
    Assignees: VISCUS BIOLOGICS, LLC, THE CLEVELAND CLINIC FOUNDATION
    Inventors: Justin Jeffrey Baker, Peter Hayes Gingras, Robert Priest, Kathe Derwin, Joseph P. Iannotti, Sambit Sahoo, Andrew Ryan Baker
  • Patent number: 11399536
    Abstract: A device for support of an organ ex vivo comprises a chamber with a first engagement feature. A support structure includes a second engagement feature. The first and second engagement features may be engaged so that the chamber body is carried by the support structure for rotation. The chamber body comprises first and second chamber components. In a first orientation of the chamber body, the first chamber component provides support for a first surface of the organ, and the second chamber component is removable so that a second surface of the organ is exposed to manipulation from outside the chamber body. In a second orientation of the chamber body, the second chamber component provides support for the second surface of the organ, and the first chamber component is removable so that the first surface of the organ is exposed to manipulation from outside the chamber body.
    Type: Grant
    Filed: September 14, 2018
    Date of Patent: August 2, 2022
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Cristiano Quintini, John W. Etterling, Daniele Pezzati, Qiang Liu, Ahmed Hassan
  • Patent number: 11399741
    Abstract: Systems and methods are provided for determining an acceleration at a location of interest within one of a user's head and neck. At least one of linear acceleration data, angular acceleration data, angular velocity data, and orientation data is produced using at least one sensing device substantially rigidly attached to an ambient-accessible surface of the user's head. The location of interest is represented relative to a position of the at least one sensing device as a time-varying function. An acceleration at the location of interest is calculated as a function of the data produced at the sensing device and the time-varying function representing the location of interest. The calculated acceleration at the location of interest is provided to at least one of the user and an observer in a human-perceptible form.
    Type: Grant
    Filed: February 4, 2020
    Date of Patent: August 2, 2022
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Edward C. Benzel, Vincent J. Miele, Adam J. Bartsch, Lars G. Gilbertson