Patents Assigned to Cleveland Clinic Foundation
  • Patent number: 12213684
    Abstract: A bone tissue collection device is provided with an exterior collection container and a porous interior filter container. The device includes a lid having an upper face and is configured to releaseably seal the exterior collection container and interior filter container. A suction inlet tube and a suction outlet tube are operably coupled to the lid and angled from the upper face of the lid.
    Type: Grant
    Filed: March 19, 2024
    Date of Patent: February 4, 2025
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventor: Guillermo Ortiz Blanco
  • Patent number: 12205686
    Abstract: Systems and methods are provided for assigning a treatment to a patient is provided. A set of genetic data representing a patient. A polygenic score representing the likelihood that a patient will benefit from intensive glycemia treatment is generated from the set of genetic data. A parameter representing a response of the patient to intensive glycemia treatment is assigned according to the polygenic score.
    Type: Grant
    Filed: February 27, 2021
    Date of Patent: January 21, 2025
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Daniel M. Rotroff, Kevin M. Pantalone, Galen Miller-Atkins, Arshiya Mariam
  • Patent number: 12194297
    Abstract: Deep brain stimulation (DBS) can be used to treat many neurological conditions beyond traditional movement disorders. When patients do not suffer from traditional movement disorders, medical professionals cannot use traditional observation-based methods to configure the DBS system. A new method for selecting stimulation configurations can include recording internal data and external data as the patient performs (or attempts to perform) a motor task. The internal data is electrophysiology data recorded by a plurality of DBS electrodes, used to identify at least one of the plurality of electrodes closest to a neuronal population involved in control of the at least one motor task. The external data is electroencephalogram (EEG) data recorded by scalp electrodes, which is used to select at least one of the potential stimulation electrodes to deliver the DBS. When the electrode(s) delivering the DBS are selected, optimal parameters for the DBS are then chosen.
    Type: Grant
    Filed: January 21, 2021
    Date of Patent: January 14, 2025
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Andre Machado, Raghavan Gopalakrishnan, Kenneth Baker
  • Patent number: 12156746
    Abstract: A sensing device can be used for ambulatory urodynamics. The sensing device can include an elongated outer housing constructed of flexible material that can curve within a patient's bladder. At least a portion of the outer housing can be filled with a non-compressible fluid. A flexible printed circuit board can be disposed within the outer housing to curve with the outer housing. The printed circuit board can include a pressure sensor, comprising a diaphragm, to collect pressure data; a microcontroller running control software; and a wireless transmitter to transmit the pressure data. A battery can be disposed within the outer housing and coupled to the printed circuit board. The flexible material of the outer housing is configured to be displaced by a pressure within the patient's bladder, the displacement is transmitted through the non-compressible fluid to the pressure sensor that provides the pressure data based on the displacement.
    Type: Grant
    Filed: May 28, 2019
    Date of Patent: December 3, 2024
    Assignees: THE CLEVELAND CLINIC FOUNDATION, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS, PARKER HANNIFIN CORPORATION
    Inventors: Margot S. Damaser, Steve Majerus, Hui Zhu, Bradley C. Gill, Ricardo Gonzalez, Daniel Greene, Joe Poliquin, Glenn Craig, Marie Lorentz, Gino Banco
  • Patent number: 12133793
    Abstract: A branched and fenestrated prosthesis may include a main tubular graft body including a proximal end opening, a distal end opening, a lumen, and a sidewall. A branch may extend from the sidewall and may include a first end opening, a second end opening, and a lumen. A fenestration may be disposed in the sidewall and positioned distal of the second end opening of the branch. The branched and fenestrated prosthesis may include a plurality of branches and a plurality of fenestrations.
    Type: Grant
    Filed: March 17, 2023
    Date of Patent: November 5, 2024
    Assignees: Cook Medical Technologies LLC, The Cleveland Clinic Foundation
    Inventors: Roy K. Greenberg, Karl J. West, Timothy A. Resch, Blayne A. Roeder
  • Patent number: 12116350
    Abstract: The present invention relates to compounds that are modulators of Integrin Linked Kinase (ILK), and methods of treating diseases with such compounds. In certain embodiments, the compounds are within Formulas I-VII (e.g., Csbl-1). In some embodiments, the compounds are used to treat an ILK-mediated disease, such as cancer (e.g., triple negative breast cancer) or an inflammatory disease.
    Type: Grant
    Filed: November 1, 2022
    Date of Patent: October 15, 2024
    Assignee: The Cleveland Clinic Foundation
    Inventors: Jun Qin, Koichi Fukuda, Julia Vaynberg, Suguna Rachakonda
  • Patent number: 12097246
    Abstract: The invention is directed to a method of treating a spinal cord injury, a neurodegenerative disease or a neuronal injury in an individual in need thereof comprising administering an effective amount of superoxide dismutase (SOD) and catalase to the individual, wherein the superoxide dismutase and the catalase are encapsulated in one or more nanoparticles that release the SOD and catalase upon administration. Another aspect of the invention is directed to compositions comprising superoxide dismutase (SOD) and catalase encapsulated in one or more nanoparticles.
    Type: Grant
    Filed: June 22, 2022
    Date of Patent: September 24, 2024
    Assignee: The Cleveland Clinic Foundation
    Inventors: Vinod Labhasetwar, Hayder H. Jaffer
  • Patent number: 12090312
    Abstract: A system for treating a patient with a heart condition includes an atrial assist device (AAD) configured to be positioned in the patients heart to pump blood from an atrium of the patients heart into a ventricle associated with the atrium. The system also includes a controller operatively connected to the AAD and being configured to control the AAD to pump blood from the atrium of the patients heart into the ventricle associated with the atrium.
    Type: Grant
    Filed: October 15, 2019
    Date of Patent: September 17, 2024
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Kiyotaka Fukamachi, Jamshid Karimov, David J. Horvath, Randall C. Starling, Barry Kuban
  • Patent number: 12092648
    Abstract: The present invention provides methods, kits, and compositions for: i) detecting the level of 3-bromotyrosine in a sample that has been treated to liberate 3-bromotyrosine from 4-O-glucuronide-3-bromotyrosine, and/or ii) detecting the level of 4-O-glucuronide-3-bromotyrosine, and/or the combined level of both 4-O-glucuronide-3-bromotyrosine and 3-bromotyrosine, in a sample that has not been treated to liberate 3-bromotyrosine from 4-O-glucuronide-3-bromotyrosine. In certain embodiments, such detected levels are used to: i) identify the presence, severity, or risk of an eosinophilic disorder (e.g., asthma or a TH2-high eosinophilic disorder); ii) identify therapy effective for treating asthma or an eosinophilic disorder; or iii) identify patients suitable for treatment with therapeutic agents targeted to asthma or an eosinophilic disorder.
    Type: Grant
    Filed: February 9, 2022
    Date of Patent: September 17, 2024
    Assignee: The Cleveland Clinic Foundation
    Inventors: Stanley L. Hazen, Zeneng Wang
  • Patent number: 12079987
    Abstract: Systems and methods are provided for fully automated quality assessment of ultra-widefield angiography images. A series of ultra-widefield angiography images of a retina of a patient are obtained and each of the series of ultra-widefield angiography images are provided to a neural network trained on a set of labeled images to generate a quality parameter for each of the series of ultra-widefield angiography images representing a quality of the image. Each of the set of labeled images are assigned to one of a plurality of classes representing image quality. A user interface provides an instruction to a user to obtain a new series of ultra-widefield angiography images of the retina of the patient if no image of the series of ultra-widefield angiography images has a quality parameter that meets a threshold value.
    Type: Grant
    Filed: September 20, 2021
    Date of Patent: September 3, 2024
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Justis P. Ehlers, Sunil K. Srivastava
  • Patent number: 12053310
    Abstract: A needle collection and counting tray for use in a clinical setting, such as an operating room, into which a user deposits used needles. The tray is then placed into a counting and identification machine the utilizes object recognition technology to identify and count the needles on the tray.
    Type: Grant
    Filed: May 2, 2022
    Date of Patent: August 6, 2024
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Thomas Kadavy, Cristiano Quintini, Douglas R. Johnston, Edward G. Soltesz, Jose Romero, William Kolosi
  • Patent number: 12055535
    Abstract: Methods of characterizing a test subject's risk of having or developing cardiovascular disease are provided. The methods include using an analytic device to determine levels of choline-related trimethylamine-containing compounds such as trimethylamine N-oxide, choline, or betaine in a biological sample obtained from the subject and comparing the levels of the choline-related trimethylamine-containing compound in the subject's biological sample to a control value. The test subject's risk of having cardiovascular disease is then characterized as higher if the levels of the choline-related trimethylamine-containing compound are higher than the control value. Also provided are methods of identifying a subject at risk of experiencing a complication of atherosclerotic cardiovascular disease, and methods of evaluating the efficacy of a cardiovascular therapeutic agent in a subject with cardiovascular disease using levels of choline-related trimethylamine-containing compounds.
    Type: Grant
    Filed: February 4, 2020
    Date of Patent: August 6, 2024
    Assignee: The Cleveland Clinic Foundation
    Inventors: Stanley L. Hazen, Zeneng Wang, Bruce S. Levison
  • Patent number: 12048523
    Abstract: System and methods are disclosed to facilitate intra-operative procedures and planning. A method can include storing tracking data in memory, the tracking data being generated by a tracking system to represent a location of an object in a tracking coordinate system of the tracking system. The method can also include storing a patient-specific implicit model in memory, the patient-specific implicit model being generated based on image data acquired for the patient to define geometry of an anatomical structure of the patient. The method can also include registering the tracking data and the patient-specific implicit model in a common three-dimensional coordinate system. The method can also include generating an output visualization representing a location of the object relative to the geometry of the anatomical structure of the patient in the common coordinate system.
    Type: Grant
    Filed: September 22, 2020
    Date of Patent: July 30, 2024
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Karl West, Vikash Goel, James Foster
  • Patent number: 12035882
    Abstract: One aspect of the present disclosure relates to an endoscope for facilitating a medical procedure by creating an anatomic space in or adjacent a target bodily tissue to be imaged. The endoscope can comprise a flexible, elongate tubular member defining a central lumen and an expandable dissecting member coupled to a distal end of the tubular member. The tubular member can further include at least one imaging channel extending longitudinally therethrough. The at least one imaging channel can include a visualization system for conveying an image from the distal end of the tubular member to a user. The expandable dissecting member can define a channel in fluid communication with the central lumen of the tubular member. The expandable dissecting member can extend beyond the distal end of the tubular member.
    Type: Grant
    Filed: March 3, 2022
    Date of Patent: July 16, 2024
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventor: Francis A. Papay
  • Patent number: 12023442
    Abstract: An intubating airway can include a first having a first guiding surface and a second articulating component that is attached to the first component via a hinge and has a second guiding surface. In a closed configuration, the first and second guiding surfaces can be flush with one another so that the first and second components collectively define a conduit having an interior passage that is dimensioned to direct a fiber-optic scope or an endotracheal tube extending through the interior passage for tracheal intubation. In an open configuration, the first and second guiding surfaces are not flush with one another so that no such conduit is formed.
    Type: Grant
    Filed: December 6, 2022
    Date of Patent: July 2, 2024
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Donn Marciniak, Erik Kraenzler
  • Patent number: 12023046
    Abstract: A bone tissue collection device is provided with an exterior collection container and a porous interior filter container. The device includes a lid having an upper face and is configured to releaseably seal the exterior collection container and interior filter container. A suction inlet tube and a suction outlet tube are operably coupled to the lid and angled from the upper face of the lid.
    Type: Grant
    Filed: March 11, 2023
    Date of Patent: July 2, 2024
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventor: Guillermo Ortiz Blanco
  • Patent number: 12018286
    Abstract: Provided herein are compositions, systems, kits, and methods for generating human podocyte cells by contacting human nephron progenitor cells with an FGFR pathway inhibitor, a BMP pathway inhibitor, and a WNT pathway inhibitor. In certain embodiments, the nephron progenitor cells are further contacted with at least one factor selected from: BMP4, BMP7, lysophosphatidic acid, and gamma-secretase inhibitor XX. In certain embodiments, the contacting the nephron progenitor cells is performed under serum-free conditions.
    Type: Grant
    Filed: September 4, 2020
    Date of Patent: June 25, 2024
    Assignee: The Cleveland Clinic Foundation
    Inventors: Oliver Wessely, Uyen Wessely, Jan Jensen, Michael Bukys
  • Patent number: 12011352
    Abstract: An apparatus for partially supporting a leaflet of a regurgitant heart valve includes at least one subvalvular device including a subvalvular supporting portion and an anchor portion. The subvalvular supporting portion and anchor portion are each at least partially formed from at least one of braided mesh strands of a first configuration, braided mesh strands of a second configuration, a balloon, a plurality of longitudinally extending struts, and a plurality of laterally extending struts. A connector neck is interposed longitudinally between, and is attached to both of, the subvalvular supporting portion and the anchor portion. The connector neck penetrates longitudinally through at least one of a base of the leaflet and an annulus of the heart valve at a manufactured puncture site.
    Type: Grant
    Filed: August 9, 2021
    Date of Patent: June 18, 2024
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Jose Navia, Samir Kapadia, Torey Hovest, Richard Geoffrion, Robert Farnan
  • Patent number: 11998708
    Abstract: A modular dilation device is provided for inserting multiple dilators into a target patient tissue site. The modular dilation device includes a first dilator and a second dilator. The first dilator has a first dilator distal end and a first dilator inner lumen. The first dilator has a first dilator side wall opening. The first dilator distal end has a first dilator open tip. The first dilator has a first dilator open slit. The first dilator open slit extends between the first dilator side wall opening and the first dilator open tip. The second dilator has a second dilator distal end and a second dilator inner lumen. The second dilator distal end has a second dilator open tip. When the second dilator is joined to the first dilator, the second dilator open tip is adjacent to the first dilator side wall opening.
    Type: Grant
    Filed: May 18, 2021
    Date of Patent: June 4, 2024
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventor: Karunakaravel Karuppasamy
  • Patent number: 11986650
    Abstract: Methods of treating acute heart failure in a patient in need thereof. Methods include inserting a therapy delivery device into a pulmonary artery of the patient and applying a therapy signal to autonomic cardiopulmonary fibers surrounding the pulmonary artery. The therapy signal affects heart contractility more than heart rate. Specifically, the application of the therapy signal increases heart contractility and treats the acute heart failure in the patient. The therapy signal can include electrical or chemical modulation.
    Type: Grant
    Filed: February 1, 2021
    Date of Patent: May 21, 2024
    Assignee: The Cleveland Clinic Foundation
    Inventors: Sandra Machado, Marc Penn, Ali R. Rezai