Abstract: One aspect of the present disclosure relates to a cannula for passing a tissue graft through soft tissue. The cannula can comprise an elongated body including oppositely disposed first and second ends and an axis that extends between the first and second ends. The elongated body can further include a passage extending between the first and second ends. The second end can include a curved portion that terminates at a sharpened, pointed tip configured to pierce and/or cut soft tissue at the surgical repair site. The tip can be axially offset from the axis of the elongated body at an angle that is less than 180°.

Abstract: A stent graft (2) for placement in the thoracic arch of a patient has a first tubular body portion (6) with a first lumen therein for placement in the ascending aorta of a patient and a second tubular body portion (8) to extend along the thoracic arch and down the descending aorta. The second tubular body portion is of a lesser diameter than the first tubular body portion. There is a step portion (10) between the first body portion and the second body portion. The step portion is joined to and continuous with the first portion and the second portion. A first side of each of the first body portion, the step portion and the second body portion are substantially aligned so that there is a step (18) defined on a second side opposite to the first side of the body portion. There is an aperture (30) in the step portion and an internal tube (32) extending from the aperture towards the first body portion.

Abstract: Imidazopyridine derivatives according to formula I are described wherein X is selected from CH, N, S, and O, Y is selected from S, CO, and O, R1 and optional R2 are independently selected from H, OH, substituted or unsubstituted C1-C6 alkyl, and substituted or unsubstituted C4-C6 cycloalkyl or cycloheteroalkyl, R3 is selected from H, OH, substituted or unsubstituted C1-C6 alkyl, and optional Z is selected from OH, NH2, NH(CO)R4, NH(SO2)R4, guanidine, alkylguanidine, and fluoroguanidine, R4 is polyethylene glycol or substituted or unsubstituted C1-C6 alkyl, and pharmaceutically acceptable salt thereof. The imidazopyridine derivatives can be used for treatment of cancer in a subject.

Abstract: A blood pump (20) includes a stator assembly comprising a motor stator (52), a fluid inlet (24), and a fluid outlet (26). A rotor assembly includes a motor rotor (54) and an impeller (40) rotatable about an axis (44) to move fluid from the inlet (24) to the outlet (26). An outflow sheath (300) directs the flow along the outside of the pump (20).

Abstract: One aspect of the present disclosure includes a system comprising prosthetic chordae, at least one attachment member including a channel, a female securing member, and a papillary penetration member configured to pass through the channel, the chordae, and the securing member when implanted in a patient's heart. The penetration member includes an axis.

Abstract: A temperature-regulating garment is provided for assisting a user with regulating body temperature. A garment body has first and second major garment body edges. The garment body has a neckline formed by a least a portion of the first major garment body edge. The garment body has a front right panel, a front left panel, and a back panel. At least one armhole is located laterally between the back panel and a selected one of the right front panel and the left front panel. First and second neck pockets are each configured to accept a temperature-regulating pack. The first neck pocket is disposed upon at least one of the right front panel and the back panel, spanning the first major garment body edge. The second neck pocket is disposed upon at least one of the left front panel and the back panel, spanning the first major garment body edge.

Abstract: A computer-implemented method for determining the volume of activation of neural tissue. In one embodiment, the method uses one or more parametric equations that define a volume of activation, wherein the parameters for the one or more parametric equations are given as a function of an input vector that includes stimulation parameters. After receiving input data that includes values for the stimulation parameters and defining the input vector using the input data, the input vector is applied to the function to obtain the parameters for the one or more parametric equations. The parametric equation is solved to obtain a calculated volume of activation.

Abstract: A tissue collection and processing system for collecting bone fragments and tissue therein. The tissue collection and processing system includes a collection vessel, a collection vessel cap and a filter container. The collection vessel has an opening formed therein. The collection vessel cap is capable of engaging the collection vessel to substantially seal the opening. The collection vessel cap or the collection vessel includes a first port and a second port. The filter container is mounted with respect to the first port.

Abstract: An apparatus for repairing the function of a diseased valve includes a tubular first support member which is expandable to a first average diameter and has oppositely disposed proximal and distal first support member ends. A tubular second support member is spaced axially apart from the first support member and is expandable to a second average diameter that is smaller than the first average diameter. The second support member has oppositely disposed proximal and distal second support member ends. A tubular graft section interconnects the first and second support members and has oppositely disposed proximal and distal graft section ends axially spaced apart by a graft section body. The proximal graft section end is connected directly to the distal first support member end and the distal graft section end is connected directly to the proximal second support member end.

Abstract: A system for delivery of radiation to a target portion of a native tissue is provided. The system includes a catheter having a catheter body with a proximal portion, a distal portion, and a longitudinally oriented lumen therebetween. The system further includes an expansion device disposed about at least a portion of the catheter body and having an expanded configuration and a non-expanded configuration. The system also includes a plurality of tubes disposed about at least a portion of the expansion device. Each of the plurality of tubes is configured to selectively guide exposure of a radiation source to the target portion of the native tissue.

Abstract: Systems and method for peripheral cannulation are provided. Systems include cannulas defining fenestrations that can be exposed or occluded by a cover slip to selectively expose fenestrations to blood flow in an artery or vein.

Abstract: A surgical guide to facilitate delivery of a therapy delivery device into the pterygopalatine fossa of a subject includes a curvilinear body having a distal end portion, a proximal end portion, and an intermediate portion extending between the distal and proximal end portions. The proximal end portion is defined by oppositely disposed first and second surfaces. The proximal end portion and the intermediate portion define a longitudinal plane that extends between the proximal and distal end portions. The distal end portion has an arcuate configuration relative to the longitudinal plane and is defined by oppositely disposed third and fourth surfaces.

Abstract: This document discusses, among other things, brain stimulation models, systems, devices, and methods, such as for deep brain stimulation (DBS) or other electrical stimulation. In an example, volumetric imaging data representing an anatomical volume of a brain of a patient can be obtained and transformed to brain atlas data. A patient-specific brain atlas can be created using the inverse of the transformation to map the brain atlas data onto the volumetric imaging data and a volume of influence can be calculated using the patient-specific brain atlas. In certain examples, the volume of influence can include a predicted volume of tissue affected by an electrical stimulation delivered by an electrode at a corresponding at least one candidate electrode target location.

Abstract: A method of treating a cardio-renal disease is described that includes administering to a subject in need thereof a therapeutically effective amount of proprotein convertase subtilisin/kexin-6 (PCSK6), or an effective fragment thereof, which functions as a corin activator.

Abstract: A clamp having at least first and second elongate clamping portions adapted to be placed on opposite sides of the hollow anatomical structure. The first and second elongate clamping portions respectively include ends coupled together with respective resilient urging members configured to urge at least one of the first and second elongate clamping portions toward the other of the first and second elongate clamping portions from an open position into a clamping position to occlude the hollow anatomical structure. The clamp includes tissue ingrowth structure on the clamping portions.

Abstract: An apparatus for providing a reference indication to a patient tissue includes a primary locating block having a patient-specific primary mating surface contoured for mating contact with a portion of the patient tissue in a predetermined primary mating orientation custom-configured responsive to preoperative imaging of the patient tissue. At least one mounting feature is provided to the primary locating block. At least one secondary item is configured for selective engagement with the primary locating block. The secondary item is at least one of a noncustomized secondary item and a patient-specific secondary item. The secondary item provides a reference indication to at least a portion of the patient tissue. The mounting feature of the primary locating block is configured for engagement with at least one secondary item in a predetermined secondary mounting relationship. The secondary mounting relationship is custom-configured for the patient tissue responsive to preoperative imaging of the patient tissue.

Abstract: One aspect of the present disclosure relates to a stereotactic guide assembly comprising an implantable body and a fastener. The implantable body can have an interior chamber and a first passageway that extends through the implantable body into communication with the interior chamber. At least a portion of the interior chamber can be defined by a first coupling feature. The fastener can be configured to fit in the interior chamber. The fastener can have a second passageway extending therethrough, and a second coupling feature adapted to releasably engage the first coupling feature.

Abstract: A method of restoring perfusion to a blood vessel with an obstruction. The method includes delivering an expandable member into the blood vessel, said expandable member having a tubular mesh defined between a proximal end and a distal end; causing the expandable member to expand and compress the obstruction; and dislodging the obstruction to restore blood flow through the blood vessel.

Abstract: A computer implemented method for determining a centerline of a three-dimensional tubular structure is described. The method includes providing an edge-detected data set of voxels that characterize a boundary of the tubular structure according to a three-dimensional voxel data set for the tubular structure. A gradient field of a distance transformation is computed for the edge-detected dataset. A voxel data set corresponding to a centerline of the tubular structure is computed according to derivative of gradient field.

Abstract: One aspect of the present disclosure can include a frame structure adapted for use with a stent graft. The frame structure can include a scallop region and a Z-form region. The scallop region can have a first end portion, a second end portion, and a perimeter that defines an aperture. The Z-form region can extend from the scallop region and include a plurality of Z-shaped struts, each of which has a first end and a second end that is connected to the scallop region at different points so as to form a central frame structure lumen. The second end portion of the scallop region can include a backstop that is deployable from a first flattened configuration to a second erect configuration. The backstop, in the second erect configuration, is sized and dimensioned to extend into a lumen of an aortic branch vessel.