Patents Assigned to Cleveland Clinic Foundation
  • Method and apparatus for increasing blood flow through an obstructed blood vessel
    Patent number: 11090070
    Abstract: A method of restoring perfusion to a blood vessel with an obstruction. The method includes delivering an expandable member into the blood vessel, said expandable member having a tubular mesh defined between a proximal end and a distal end; causing the expandable member to expand and compress the obstruction; and dislodging the obstruction to restore blood flow through the blood vessel.
    Type: Grant
    Filed: January 30, 2019
    Date of Patent: August 17, 2021
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: David Fiorella, Henry Woo
  • Ovarian cancer vaccines
    Patent number: 11090284
    Abstract: Provided herein are methods, kits and compositions for the treatment and/or prevention of ovarian cancer through the induction of an immune response against Anti-Mullerian Hormone Receptor, Type II (AMHR2).
    Type: Grant
    Filed: September 2, 2016
    Date of Patent: August 17, 2021
    Assignee: The Cleveland Clinic Foundation
    Inventors: Vincent K. Tuohy, Suparna Mazumder, Justin M. Johnson
  • Methods of treating airway stenosis
    Patent number: 11083560
    Abstract: Methods of treating airway stenosis are provided. Methods include gradually dilating the stenotic region of a patient's airway lumen with sequentially implanted customized airway stents. The airway stents are sequentially implanted until the diameter of the stenotic region of the patient's airway has substantially the same diameter as the diameter of an adjacent healthy region of the patient's airway lumen.
    Type: Grant
    Filed: January 14, 2020
    Date of Patent: August 10, 2021
    Assignees: THE CLEVELAND CLINIC FOUNDATION, NEW COS INC
    Inventors: Thomas Gildea, Keith Grafmeyer
  • Gradually-expandable stent apparatus and method
    Patent number: 11076954
    Abstract: A gradually-expandable stent includes a base ring completely encircling a central valve-accepting area. A plurality of uprights is provided. Each upright includes two longitudinally extending upright struts. Each upright strut has a strut base directly connected to the base ring and a strut tip directly attached to the other strut tip of the upright strut at a rounded upright apex. The upright apex is longitudinally spaced from the base ring. At least one expansion feature is associated with the base ring and gradually expands to enlarge the central valve-accepting area toward a maximum valve-accepting area responsive to growth of the patient over an extended dwell time.
    Type: Grant
    Filed: September 20, 2018
    Date of Patent: August 3, 2021
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Hani Najm, Kelly B. Emerton, Alex Lewis, Justin Metcalf
  • Endovascular grafts and methods for extended aortic repair
    Patent number: 11076945
    Abstract: An endovascular graft including a stent graft and a surgical graft is provided. The stent graft can include an elongated body having a collapsed and expanded configuration and include a frame structure covered by a compression sleeve that retains the elongated body in the collapsed configuration until deployment of the stent graft. The endovascular graft can include a first cuff member sized and dimensioned to extend into a lumen of an aortic arch branch vessel when the endovascular graft is implanted in a subject. The frame structure can include a backstop sized and dimensioned to extend into the first cuff member when the endovascular graft is implanted in the subject. The surgical graft can be partially attached to the stent graft at a proximal end portion thereof.
    Type: Grant
    Filed: October 9, 2018
    Date of Patent: August 3, 2021
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Eric E. Roselli, Kelly B. Emerton, Justin Metcalf, Brandon Gulker
  • Thoracic aorta stent graft with access region
    Patent number: 11071636
    Abstract: A stent graft (2) for placement in the thoracic arch of a patient has a first tubular body portion (6) with a first lumen therein for placement in the ascending aorta of a patient and a second tubular body portion (8) to extend along the thoracic arch and down the descending aorta. The second tubular body portion is of a lesser diameter than the first tubular body portion. There is a step portion (10) between the first body portion and the second body portion. The step portion is joined to and continuous with the first portion and the second portion. A first side of each of the first body portion, the step portion and the second body portion are substantially aligned so that there is a step (18) defined on a second side opposite to the first side of the body portion. There is an aperture (30) in the step portion and an internal tube (32) extending from the aperture towards the first body portion.
    Type: Grant
    Filed: April 1, 2019
    Date of Patent: July 27, 2021
    Assignees: COOK MEDICAL TECHNOLOGIES LLC, THE CLEVELAND CLINIC FOUNDATION
    Inventors: David E. Hartley, Roy K. Greenberg, Krasnodar Ivancev, Michael Lawrence-Brown
  • Predicting response to immunotherapy using computer extracted features of cancer nuclei from hematoxylin and eosin (HandE) stained images of non-small cell lung cancer (NSCLC)
    Patent number: 11055844
    Abstract: Embodiments access a digitized image of tissue demonstrating non-small cell lung cancer (NSCLC), the tissue including a plurality of cellular nuclei; segment the plurality of cellular nuclei represented in the digitized image; extract a set of nuclear radiomic features from the plurality of segmented cellular nuclei; generate at least one nuclear cell graph (CG) based on the plurality of segmented nuclei; compute a set of CG features based on the nuclear CG; provide the set of nuclear radiomic features and the set of CG features to a machine learning classifier; receive, from the machine learning classifier, a probability that the tissue will respond to immunotherapy, based, at least in part, on the set of nuclear radiomic features and the set of CG features; generate a classification of the tissue as a responder or non-responder based on the probability; and display the classification.
    Type: Grant
    Filed: February 21, 2019
    Date of Patent: July 6, 2021
    Assignees: Case Western Reserve University, The Cleveland Clinic Foundation
    Inventors: Anant Madabhushi, Xiangxue Wang, Cristian Barrera, Vamsidhar Velcheti
  • Ventricular assist device with pulse augmentation and automatic regurgitant flow shutoff
    Patent number: 11045639
    Abstract: A ventricular assist device includes a housing including a pumping chamber. A stator assembly is supported in the housing. The stator assembly includes a core having a length measured along a pump axis. A rotating assembly is rotatable relative to the stator assembly about the pump axis. The rotating assembly includes an impeller positioned in the pumping chamber and a rotor magnet. The rotating assembly is movable axially along the pump axis relative to the pump housing and the stator assembly. The rotating assembly includes a rotor magnet configured and arranged such that the magnetic attraction of the rotor magnet to the core urges the rotating assembly to move axially relative to the stator assembly such that a flow regulating portion of the rotating assembly engages with a corresponding portion of the housing to block flow through the pumping chamber when the pump is at rest.
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: June 29, 2021
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: David J. Horvath, Leonard A R. Golding, Barry D. Kuban, Kiyotaka Fukamachi
  • Urine biomarkers for detecting graft rejection
    Patent number: 11041208
    Abstract: Provided herein are compositions, systems, kits, and methods for detecting rejection, or an elevated risk of rejection, of an organ or tissue graft (e.g., kidney graft) in a subject by detecting one, or a panel of, RNA markers in a urine sample from the subject. In certain embodiments, kidney graft injury is detected by measuring one or more of the RNA markers disclosed herein. In some embodiments, the one or more markers are employed to distinguish between acute graft rejection and BK virus nephropathy.
    Type: Grant
    Filed: August 23, 2018
    Date of Patent: June 22, 2021
    Assignees: THE CLEVELAND CLINIC FOUNDATION, THE UAB RESEARCH FOUNDATION
    Inventors: Robert L. Fairchild, Roslyn Bernstein Mannon
  • ABCA1 downregulation in prostate cancer
    Patent number: 11041212
    Abstract: A method of providing a prognosis or diagnosis of prostate cancer in a subject is described. The method includes obtaining a urine or prostate sample from the subject; determining the level of expression of ABCA1 in the sample; and comparing the level of expression of ABCA1 in the sample to the level of a control sample, wherein a decreased level of ABCA1 expression compared to the control indicates the subject has prostate cancer or a more severe form of prostate cancer. Methods of treating subjects identified as having prostate cancer, and kits for carrying out the method of prognosis or diagnosis are also described.
    Type: Grant
    Filed: July 30, 2018
    Date of Patent: June 22, 2021
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Angela H. Ting, Byron H. Lee
  • Sterile and/or purified fluid and/or solution delivery system
    Patent number: 11021378
    Abstract: A system for on-demand delivery of a sterile fluid includes a housing. At least one fluid reservoir is associated with the housing and configured to hold a fluid. A sterilization and/or purification mechanism is in fluid communication with the at least one fluid reservoir. The sterilization and/or purification mechanism is configured to sterilize the fluid. A dispensing mechanism is in fluid communication with the sterilization mechanism and configured to dispense the sterile fluid. A controller is associated with one or more of the housing, the at least one fluid reservoir, the sterilization and/or purification mechanism, and the dispensing mechanism. The controller being configured to modulate at least one operating characteristic of the system. The system is configured to deliver the sterile and/or purified fluid immediately after a request is made.
    Type: Grant
    Filed: March 14, 2016
    Date of Patent: June 1, 2021
    Assignees: THE CLEVELAND CLINIC FOUNDATION, PARKER-HANNIFIN CORPORATION
    Inventors: Joseph Foss, William Kolosi, Dale Ashby, Gino Banco, Paul Resendes
  • Method and apparatuses for accessing and/or modifying a target patient tissue site
    Patent number: 11020573
    Abstract: A modular dilation device (100) is provided for inserting multiple dilators into a target patient tissue site. The modular dilation device includes a first dilator (104) and a second dilator (530). The first dilator has a first dilator distal end (108) and a first dilator inner lumen (114). The first dilator has a first dilator side wall opening (118). The first dilator distal end has a first dilator open tip (116). The first dilator has a first dilator open slit (120). The first dilator open slit extends between the first dilator side wall opening and the first dilator open tip. The second dilator has a second dilator distal end and a second dilator inner lumen. The second dilator distal end has a second dilator open tip. When the second dilator is joined to the first dilator, the second dilator open tip is adjacent to the first dilator side wall opening.
    Type: Grant
    Filed: October 13, 2017
    Date of Patent: June 1, 2021
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventor: Karunakaravel Karuppasamy
  • Reinforced tissue graft
    Patent number: 11013590
    Abstract: A biocompatible tissue graft includes a first layer of a bioremodelable collageneous material, a second layer of biocompatible synthetic or natural remodelable or substantially remodelable material attached to the first layer; and at least one fiber that is stitched in a reinforcing pattern in the first layer and/or second layer to mitigate tearing and/or improve fixation retention of the graft, and substantially maintain the improved properties while one or more of the layers is remodeling.
    Type: Grant
    Filed: May 1, 2015
    Date of Patent: May 25, 2021
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Kathleen A. Derwin, Joseph P. Iannotti, Sambit Sahoo
  • Radiomic features of prostate bi-parametric magnetic resonance imaging (BPMRI) associate with decipher score
    Patent number: 11017896
    Abstract: Embodiments facilitate predicting a patient prostate cancer (PCa) DECIPHER risk group. A first set of embodiments relates to training of a machine learning classifier to compute a probability that a patient is a member of a DECIPHER low/intermediate risk group based on radiomic features extracted from bi-parametric magnetic resonance imaging (bpMRI) images. A second set of embodiments relates to classifying a patient as a member of DECIPHER low/intermediate risk group, or DECIPHER high-risk group, based on radiomic features extracted from bpMRI imagery of the patient.
    Type: Grant
    Filed: April 26, 2019
    Date of Patent: May 25, 2021
    Assignees: Case Western Reserve University, The Cleveland Clinic Foundation
    Inventors: Anant Madabhushi, Lin Li, Andrei S. Purysko, Rakesh Shiradkar
  • Nanoparticles for drug delivery to treat bone disease
    Patent number: 11013817
    Abstract: Provided herein are compositions, systems, kits, and methods for treating cancer in at least one bone of a subject using nanoparticles encapsulating, or conjugated to, an anti-cancer agent. In other embodiments, provided herein are composition, systems, kits, and methods for treating a bone disease (e.g., osteoporosis) in a subject using nanoparticle encapsulating, or conjugated to, a RANKL inhibitor. The nanoparticle are, in certain embodiments, neutral or nearly neutral in charge (e.g., zeta potential between ?5 and +5 mV) and less than 250 nm in diameter on average (e.g. have an average diameter between 100 and 200 nm).
    Type: Grant
    Filed: April 7, 2017
    Date of Patent: May 25, 2021
    Assignee: The Cleveland Clinic Foundation
    Inventors: Vinod Labhasetwar, Isaac M. Adjei
  • Method and garment for assisting a wearer with regulating body temperature
    Patent number: 10993486
    Abstract: A temperature-regulating garment is provided for assisting a user with regulating body temperature. A garment body has first and second major garment body edges. The garment body has a neckline formed by a least a portion of the first major garment body edge. The garment body has a front right panel, a front left panel, and a back panel. At least one armhole is located laterally between the back panel and a selected one of the right front panel and the left front panel. First and second neck pockets are each configured to accept a temperature-regulating pack. The first neck pocket is disposed upon at least one of the right front panel and the back panel, spanning the first major garment body edge. The second neck pocket is disposed upon at least one of the left front panel and the back panel, spanning the first major garment body edge.
    Type: Grant
    Filed: May 31, 2019
    Date of Patent: May 4, 2021
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventor: Jill Elizabeth Byrne
  • Compositions and methods for modulating toll-like receptor 2 activation
    Patent number: 10987408
    Abstract: A method of promoting hair growth of a subject includes administering to follicle cells of the subject a therapeutically effective amount of a TLR2 agonist that promotes TLR2 activation and hair growth of the subject.
    Type: Grant
    Filed: May 2, 2018
    Date of Patent: April 27, 2021
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventor: Tatiana Byzova
  • System and method to estimate region of tissue activation
    Patent number: 10981013
    Abstract: A computer-implemented method for determining the volume of activation of neural tissue. In one embodiment, the method uses one or more parametric equations that define a volume of activation, wherein the parameters for the one or more parametric equations are given as a function of an input vector that includes stimulation parameters. After receiving input data that includes values for the stimulation parameters and defining the input vector using the input data, the input vector is applied to the function to obtain the parameters for the one or more parametric equations. The parametric equation is solved to obtain a calculated volume of activation.
    Type: Grant
    Filed: June 4, 2019
    Date of Patent: April 20, 2021
    Assignee: The Cleveland Clinic Foundation
    Inventors: J. Luis Lujan, Ashutosh Chaturvedi, Cameron McIntyre
  • Trimethylamine-containing compounds for diagnosis and prediction of disease
    Patent number: 10983100
    Abstract: The present invention provides markers and methods for determining whether a subject, particularly a human subject, has or is at risk of developing, a disease such as cardiovascular disease, diabetes mellitus, insulin resistance, metabolic syndrome, NAFLD (Nonalcoholic Fatty Liver Disease) or NASH (Nonalcoholic Steatohepatitis) (e.g., within the ensuing year, two years, and/or three years). The present application also relates to the use of such markers and methods for monitoring the status of such diseases in a subject or the effects of therapeutic agents on subjects with such diseases.
    Type: Grant
    Filed: February 1, 2019
    Date of Patent: April 20, 2021
    Assignee: The Cleveland Clinic Foundation
    Inventors: Stanley L. Hazen, Zeneng Wang, Bruce S. Levison
  • System of preoperative planning and provision of patient-specific surgical aids
    Patent number: 10973535
    Abstract: A method of preoperative planning comprises creating a virtual model of a native patient tissue; placing a virtual device into a desired device orientation relative to the virtual model of the native patient tissue; specifying at least one structural change to the native patient tissue to facilitate placement of the virtual device in the desired device orientation; creating a virtual model of an altered patient tissue responsive to the specifying at least one structural change to the native patient tissue; and fabricating a tangible representation of a bone using the virtual model of the altered patient tissue.
    Type: Grant
    Filed: July 6, 2017
    Date of Patent: April 13, 2021
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Joseph P. Iannotti, Wael K. Barsoum, Jason A. Bryan, Peter D. O'Neill