Patents Assigned to Cleveland State University
  • Patent number: 12045289
    Abstract: Disclosed is a system and method for processing data using blockchain technology. The system includes a memory having programmable instructions stored thereon that, when executed by a processor, cause the system to: authenticate one or more sensors in anticipation of receiving component data; receive component data, upon successful authentication; store the component data locally or to a cloud-based server and/or calculate a root value for the component data; store or embed the root value with the stored component data; condense the component data and link the condensed component data to the stored component data via the root value. The system further includes instructions to log the condensed data, including the root value, to a ledger, and to identify a tag or transaction id corresponding to the logging event for subsequent retrieval of the condensed data using the tag or transaction id.
    Type: Grant
    Filed: March 11, 2021
    Date of Patent: July 23, 2024
    Assignee: Cleveland State University
    Inventor: Wenbing Zhao
  • Publication number: 20240157310
    Abstract: A process for separating carbon dioxide from acetylene utilizes a CHA-type zeolite membrane.
    Type: Application
    Filed: November 14, 2023
    Publication date: May 16, 2024
    Applicant: Cleveland State University
    Inventors: Shaowei Yang, Ninad D. Anjikar
  • Patent number: 11959110
    Abstract: During the process of coagulation, prothrombin is activated to ?-thrombin by prothrombinase. Key residues in the structure of prothrombin allow for modulation of the activation of prothrombin. In certain embodiments, a recombinant prothrombin with at least one point mutation or deletion is provided.
    Type: Grant
    Filed: January 25, 2021
    Date of Patent: April 16, 2024
    Assignee: Cleveland State University
    Inventors: Michael Kalafatis, Joseph Wiencek
  • Publication number: 20240082433
    Abstract: A tumor resection process includes the administration of an iridium-containing nucleoside, medical imaging, and tumor and tumor margin removal.
    Type: Application
    Filed: August 21, 2023
    Publication date: March 14, 2024
    Applicant: Cleveland State University
    Inventor: Anthony J. Berdis
  • Publication number: 20230310474
    Abstract: An antiviral composition contains a sialidase inhibitor. Methods for treating a viral infection include administering the composition to a patient. The sialidase inhibitor may be of general formula (l) wherein R1 is selected from the group consisting of OH, O-acetyl, N3, OCOCH2X1 and NHCOCHX1; X1 is selected from the group consisting of H, a C1-C5 alkyl group, acetyl, propionyl, butyryl, valoryl, hexanoyl, pentanoyl, and 2-methylpropanyl; R2 is H or COCH2X2; X2 is selected from the group consisting of H, a C1-C5 alkyl group, acetyl, propionyl, butyryl, valoryl, hexanoyl, pentanoyl, and 2-methylpropanyl; R3 is selected from the group consisting of H, OH, COCH2X3 and OCOCH2X3; X3 is selected from the group consisting of H, a C1-C5 alkyl group, acetyl, propionyl, butyryl, valoryl, hexanoyl, pentanoyl, and 2-methylpropanoal; R4 is selected from the group consisting of H, OH, a C1-C6 alkyl group, and CH2X4; and X4 is H or a C1-C6 alkyl group.
    Type: Application
    Filed: February 13, 2023
    Publication date: October 5, 2023
    Applicants: Cleveland State University, University of Tennessee Research Foundation
    Inventors: Xue-Long Sun, Guoyun Chen
  • Patent number: 11773357
    Abstract: A perfusion plate that can be combined with pillar plates containing cell layers is disclosed. The perfusion plate can have an inflow reservoir and an outflow reservoir connected by at least one channel, which fluidly connects the perfusion wells to the reservoirs for the flow of a fluid such as growth media. A perfusion plate can be part of an assembly containing a pillar plate, a lid, and a transparent bottom for visualizing cell growth in the perfusion wells. The perfusion-pillar plate assembly can facilitate perfusion-based tissue culture and tissue communication for high throughput, high-content, drug screening.
    Type: Grant
    Filed: October 23, 2020
    Date of Patent: October 3, 2023
    Assignee: Cleveland State University
    Inventor: Moo-Yeal Lee
  • Patent number: 11727780
    Abstract: Systems and methods to perform privacy-aware computer-vision-based human activity monitoring with real-time haptic feedback. The system and method described in this disclosure employing a registration process for consenting human subjects before their activities are monitored. The registration process involves the corroboration of human motion captured in different modalities, i.e., computer-vision-based via the programmable computer-vision-based motion sensor and accelerometer-based via the wearable device. The tracked human activities are assessed in real-time and upon detection of activities that violated predefined rules, haptic feedback is delivered in real-time to the tracked human subject via the wearable device worn by the caregiver.
    Type: Grant
    Filed: February 18, 2019
    Date of Patent: August 15, 2023
    Assignee: Cleveland State University
    Inventor: Wenbing Zhao
  • Publication number: 20230151114
    Abstract: Therapeutic compositions and methods for treating a patient having sickle cell anemia or beta-thalassmia by administering, in therapeutically effective amounts, a composition of an effective amount of an inhibitor of Pumilio-1.
    Type: Application
    Filed: November 15, 2022
    Publication date: May 18, 2023
    Applicant: Cleveland State University
    Inventors: Merlin Nithya Gnanapragasam, Mahesh Ramamoorthy
  • Patent number: 11494854
    Abstract: The present disclosure pertains to a system that may be configured to operate a power grid, including generation participants, consumers, and a controller that administers a market for the power generation participants and the consumers on the power grid. The operation of the power grid may include: performing power grid coordination calculations based upon, at least in part, constraints that pertain to the flow and/or congestion of power on the grid; and managing the coordination calculations by reducing a number of constraints used in the coordination calculations, the managing including a first step of coarse screening of the constraints, a second step of deterministic fine screening of the constraints, and a third step of statistical fine screening of the constraints. This second step may cause identification of constraints that are redundant and/or dominated by other constraints.
    Type: Grant
    Filed: February 6, 2020
    Date of Patent: November 8, 2022
    Assignees: Midcontinent Independent System Operator, Inc., Cleveland State University
    Inventors: Hongxing Ye, Fengyu Wang, Shubo Zhang, Stephen M. Rose, Yonghong Chen, Yaming Ma
  • Publication number: 20220305720
    Abstract: An article (e.g., an interbody device) contains a polymer (e.g., polyetheretherketone (PEEK)) and transition metal-doped amorphous magnesium phosphate.
    Type: Application
    Filed: March 29, 2022
    Publication date: September 29, 2022
    Applicant: Cleveland State University
    Inventor: Prabaha Sikder
  • Patent number: 11390836
    Abstract: A micropillar and microwell chip and methods of studying cellular environments using micropillar and microwell chips is disclosed. The micropillar chip may include at least one micropillar with a pillar-microwell. The microwell chip may include at least one microwell with an upper and a lower microwell. A perfusion channel chip that may be integrated with a micropillar chip is also disclosed. The perfusion channel chip may include a channel, a pillar-insertion hole, a membrane cassette, and a reservoir well.
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: July 19, 2022
    Assignee: Cleveland State University
    Inventor: Moo-Yeal Lee
  • Patent number: 11393318
    Abstract: Systems and methods to perform privacy-aware computer-vision-based human activity monitoring with automatic registration are disclosed. To register for tracking, consenting human subjects wear beacons that emit a beacon signal. During a predefined timing window, beacon signals are detected and compared to a predefined signal-strength threshold and compared to the signal strength of other different beacon signals detected during the same timing window. At the end of the timing window, the strongest beacon signal above the threshold is selected for registration. The tracked human activities are assessed in real-time and upon detection of activities that violated predefined rules, feedback is delivered in real-time to the tracked human subject.
    Type: Grant
    Filed: October 7, 2019
    Date of Patent: July 19, 2022
    Assignee: Cleveland State University
    Inventor: Wenbing Zhao
  • Patent number: 11360077
    Abstract: Disclosed are methods and compositions for identifying and treating certain conditions and diseases. In certain instances, the general inventive concepts provide methods for determining rhTRAIL sensitivity of a sample and/or methods and compositions for inducing apoptosis to treat conditions and diseases with rhTRAIL.
    Type: Grant
    Filed: March 12, 2018
    Date of Patent: June 14, 2022
    Assignee: Cleveland State University
    Inventors: Michael Kalafatis, Katherine Turner
  • Patent number: 11262349
    Abstract: A multiplexed method of monitoring immune-cell responses to different ligands using a micropillar/microwell plate platform is disclosed. The method may include dispensing immune cells onto at least one micropillar chip and inserting the at least one micropillar into at least one microwell on a microwell chip, in which the at least one microwell contains at least one test compound. The method may also include immobilizing antibodies onto at least one micropillar on a micropillar chip and inserting the at least one micropillar into at least one microwell on a microwell chip, in which the at least one microwell contains a test compound. The method may also include treating the micropillar chip with at least one reactive polymer.
    Type: Grant
    Filed: October 11, 2018
    Date of Patent: March 1, 2022
    Assignee: Cleveland State University
    Inventors: Moo-Yeal Lee, Xue-Long Sun
  • Publication number: 20210365568
    Abstract: The present exemplary embodiments relate to a privacy preserving approach to peak load management. It finds example application in conjunction with, for example, power systems, such as smart homes, smart buildings, microgrids, distribution systems and bulk systems, and energy management systems.
    Type: Application
    Filed: May 21, 2021
    Publication date: November 25, 2021
    Applicant: Cleveland State University
    Inventor: Hongxing Ye
  • Publication number: 20210275412
    Abstract: Compositions contain boron nitride nanomaterials at least partially coated with biomolecules.
    Type: Application
    Filed: March 8, 2021
    Publication date: September 9, 2021
    Applicant: Cleveland State University
    Inventor: Geyou Ao
  • Publication number: 20210267644
    Abstract: A metal plate contains a shape memory alloy (e.g., a nitinol alloy) capable of exhibiting the one-way memory effect.
    Type: Application
    Filed: March 2, 2021
    Publication date: September 2, 2021
    Applicant: Cleveland State University
    Inventors: Josiah S. Owusu-Danquah, Brian L. Davis, Tanetta L. Curenton
  • Publication number: 20210162456
    Abstract: A method for producing an aligned boron nitride nanotube film includes drying a dispersion containing boron nitride nanotubes, a biopolymer, and a solvent.
    Type: Application
    Filed: January 29, 2020
    Publication date: June 3, 2021
    Applicant: Cleveland State University
    Inventor: Geyou Ao
  • Publication number: 20210123007
    Abstract: A perfusion plate that can be combined with pillar plates containing cell layers is disclosed. The perfusion plate can have an inflow reservoir and an outflow reservoir connected by at least one channel, which fluidly connects the perfusion wells to the reservoirs for the flow of a fluid such as growth media. A perfusion plate can be part of an assembly containing a pillar plate, a lid, and a transparent bottom for visualizing cell growth in the perfusion wells. The perfusion-pillar plate assembly can facilitate perfusion-based tissue culture and tissue communication for high throughput, high-content, drug screening.
    Type: Application
    Filed: October 23, 2020
    Publication date: April 29, 2021
    Applicant: Cleveland State University
    Inventor: Moo-Yeal Lee
  • Publication number: 20210118558
    Abstract: Methods and systems for improving healthcare through community engagement are provided. In one embodiment, a method includes initializing a community health application on a computing device for an engagement session with a candidate patient. A client identification sequence is performed using the application to enroll the candidate patient as a new community health client or lookup the candidate patient as an existing community health client. Certain client information is collected from the community health client via interaction with the computing device by a healthcare facilitator during the engagement session. The community health application controlling the computing device by presenting displays and reading data in relation to the displays. The client information is processed to select a clinical sequence for the engagement session with the community health client based on the client information.
    Type: Application
    Filed: October 16, 2020
    Publication date: April 22, 2021
    Applicant: Cleveland State University
    Inventor: William A. MATCHAM