Patents Assigned to Cliniques Universitaires Saint Luc
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Patent number: 11203785Abstract: The present invention relates to a method for assessing, evaluating and/monitoring the purity of a mesenchymal stem cells preparation, in particular of an adipose stem cells preparation, comprising measuring the expression level of at least one growth factor.Type: GrantFiled: May 9, 2016Date of Patent: December 21, 2021Assignees: UNIVERSITÉ CATHOLIQUE DE LOUVAIN, CLINIQUES UNIVERSITAIRES SAINT-LUC, NOVADIP BIOSCIENCES SAInventor: Denis Dufrane
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Patent number: 10857264Abstract: Biomaterial having a multi-dimensional structure and comprising demineralized bone matrix dispersed within differentiated mesenchymal stem cells (MSCs) tissue, wherein MSCs are adipose tissue-derived stem cells. Method for producing this biomaterial comprising incubating MSCS in osteoblastic and/or chondrongenic medium in presence of demineralized bone matrix. Use of this biomaterial for alleviating or treating a bone or cartilage defect, supporting or correcting a congenital or acquired abnormality, supporting a bon or articular bone replacement following surgery or trauma, and/or supporting a musculoskeletal implant.Type: GrantFiled: July 7, 2017Date of Patent: December 8, 2020Assignees: Universite Catholique De Louvain, Cliniques Universitaires Saint-LucInventors: Denis Dufrane, Christian Delloye
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Patent number: 10292818Abstract: A device (100) for the excision of a heart valve via a percutaneous route having a proximal (20) and distal (30) end, comprising an expandable cutting instrument, ECI, that forms a receptacle in the open configuration for receiving, compacting and containing the excised heart valve, an expandable cutting block, ECB, and a displacement mechanism (5, 6) for adjusting the distance between the ECI and the ECB (70).Type: GrantFiled: March 14, 2013Date of Patent: May 21, 2019Assignees: UNIVERSITE CATHOLIQUE DE LOUVAIN, CLINIQUES UNIVERSITAIRES SAINT LUCInventors: Parla Astarci, Khanh Tran Duy, Benoît Raucent, Xavier Bollen, Benoît Herman
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Publication number: 20180135124Abstract: The present invention relates to a method for assessing, evaluating and/monitoring the purity of a mesenchymal stem cells preparation, in particular of an adipose stem cells preparation, comprising measuring the expression level of at least one growth factor.Type: ApplicationFiled: May 9, 2016Publication date: May 17, 2018Applicants: UNIVERSITÉ CATHOLIQUE DE LOUVAIN, CLINIQUES UNIVERSITAIRES SAINT-LUC, NOVADIP BIOSCIENCES SAInventor: Denis DUFRANE
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Patent number: 9713656Abstract: Biomaterial having a multi-dimensional structure and comprising demineralized bone matrix dispersed within differentiated mesenchymal stem cells (MSCs) tissue, wherein MSCs are adipose tissue-derived stem cells. Method for producing this biomaterial comprising incubating MSCS in osteoblastic and/or chondrongenic medium in presence of demineralized bone matrix. Use of this biomaterial for alleviating or treating a bone or cartilage defect, supporting or correcting a congenital or acquired abnormality, supporting a bon or articular bone replacement following surgery or trauma, and/or supporting a musculoskeletal implant.Type: GrantFiled: June 4, 2010Date of Patent: July 25, 2017Assignees: UNIVERSITE CATHOLIQUE DE LOUVAIN, CLINIQUES UNIVERSITAIRES SAINT-LUCInventors: Denis Dufrane, Christian Delloye
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Publication number: 20120087958Abstract: Biomaterial having a multi-dimensional structure and comprising differentiated MSCs tissue and demineralised bone matrix, wherein said demineralised bone matrix is dispersed within the differentiated MSCs tissue, method for producing the same and use thereof.Type: ApplicationFiled: June 4, 2010Publication date: April 12, 2012Applicants: CLINIQUES UNIVERSITAIRES SAINT-LUC, UNIVERSITE CATHOLIQUE DE LOUVAINInventors: Denis Dufrane, Christian Delloye
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Publication number: 20100273671Abstract: Methods for the determination and the classification of a rheumatic condition in a synovial sample of a subject afflicted with a rheumatic condition are disclosed. Methods include the steps of determining in the level of expression of at least 20 genes or gene fragments in the synovial sample and identifying whether the level of expression of the genes in the sample correlates with the presence of a rheumatic condition. Kits are also described for the determination and the classification of rheumatic conditions which contain a low density microarray having probes suitable for hybridizing with at least 20 genes or gene fragments. On the basis of the hybridization results, the rheumatic condition is determined.Type: ApplicationFiled: February 29, 2008Publication date: October 28, 2010Applicants: Universite Catholique de Louvain, Cliniques Universitaires Saint-LucInventors: Bernard Lauwerys, Benoit Van Den Eynde, Frédéric Houssiau, Ilse Gutierrez-Roelens
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Publication number: 20100185211Abstract: The present invention concerns hybrid manual-robotic system for supporting and moving a surgical instrument having active main structure (100) that comprises: a) a base (2) for attachment to an operating table having an operating surface (150); b) a hexahedral-shape frame (3), which shape is formed from a first (5, 5?) and second (4, 4?) pair of opposing parallelograms and opposing proximal (6?) and distal (6) rectangles, which frame (3) is formed by at least seven links (7, 8, 9, 10, 11, 12, 13, 22, 23) connected by revolute joints (14, 15, 16, 17, 18, 19, 20, 26, 27, 109), whereby a) a pair of parallel base links (7, 13) of the proximal rectangle (6?) is coupled to the base (2) by two revolute joints (116, 117), and are configured to lie and remain essentially perpendicular to the plane of the 10 operating surface (150) and to revolve around their longitudinal axes that coincide with the axes of revolution of joints (116, 117), whereby b) said revolute joints are configured to allow the hexahedral frame (3)Type: ApplicationFiled: June 12, 2008Publication date: July 22, 2010Applicants: UNIVERSITE CATHOLIQUE DE LOUVAIN, CLINIQUES UNIVERSITAIRES SAINT-LUCInventors: Benoit Herman, Benoit Raucent, Khanh Tran Duy, Jacques Donnez, Roland Polet
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Publication number: 20090191573Abstract: A method for determining antigen content in a region of interest of a sample is disclosed. The method includes a sequential immunomarking resulting in two chromogenic signals, which are respectively provided by a labile and a stabile chromogenic product. The method further involves acquisition, analysis and evaluation of digital images from such signals. A kit for determining antigen content in a region of interest of a sample is also described.Type: ApplicationFiled: August 24, 2007Publication date: July 30, 2009Applicants: Universite Catholique de Louvain, Cliniques Universitaires Saint LucInventors: Pierre Moulin, Yves Guiot, Jacques Rahier