Patents Assigned to CLSN Laboratories, Inc.
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Publication number: 20180303957Abstract: Compositions, methods, and applications that increase the efficiency of nucleic acid transfection are provided. In one aspect, a pharmaceutical composition may include at least about 0.5 mg/ml concentration of a nucleic acid condensed with a cationic lipopolymer suspended in an isotonic solution, where the cationic lipopolymer includes a cationic polymer backbone having cholesterol and polyethylene glycol covalently attached thereto, and wherein the molar ratio of cholesterol to cationic polymer backbone is within a range of from about 0.1 to about 10, and the molar ratio of polyethylene glycol to cationic polymer backbone is within a range of from about 0.1 to about 10. The composition further may include a filler excipient.Type: ApplicationFiled: November 27, 2017Publication date: October 25, 2018Applicant: CLSN Laboratories, Inc.Inventors: Majed MATAR, Jason FEWELL, Danny H. LEWIS, Khursheed ANWER
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Patent number: 9827331Abstract: Compositions, methods, and applications that increase the efficiency of nucleic acid transfection are provided. In one aspect, a pharmaceutical composition may include at least about 0.5 mg/ml concentration of a nucleic acid condensed with a cationic lipopolymer suspended in an isotonic solution, where the cationic lipopolymer includes a cationic polymer backbone having cholesterol and polyethylene glycol covalently attached thereto, and wherein the molar ratio of cholesterol to cationic polymer backbone is within a range of from about 0.1 to about 10, and the molar ratio of polyethylene glycol to cationic polymer backbone is within a range of from about 0.1 to about 10. The composition further may include a filler excipient.Type: GrantFiled: September 25, 2015Date of Patent: November 28, 2017Assignee: CLSN Laboratories, Inc.Inventors: Majed Matar, Jason Fewell, Danny H. Lewis, Khursheed Anwer
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Publication number: 20160331686Abstract: The present invention provides compositions of yeast extracellular vesicles comprising biologically active molecules, methods for making the same, and methods for the use of the yeast extracellular vesicles to deliver biologically active molecules to target cells. In addition, the invention provides cells and compositions comprising the biologically active molecules and vesicles, which can be used as transfection reagents. The invention further provides methods for producing said compositions of biologically active molecules with vesicles as well as the cells that produce those compositions. Compositions and methods for delivering biologically active molecules, such as a small molecule, a DNA expression plasmid, an RNA molecule, a peptide, or a protein, to cells and/or tissues are provided.Type: ApplicationFiled: May 11, 2016Publication date: November 17, 2016Applicant: CLSN Laboratories, Inc.Inventors: Kevin J. POLACH, Daniel W. Neef, Jason G. Fewell, Khursheed Anwer
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Publication number: 20160243256Abstract: Compositions, methods, and applications that increase the efficiency of nucleic acid transfection are provided. In one aspect, a pharmaceutical composition may include at least about 0.5 mg/ml concentration of a nucleic acid condensed with a cationic lipopolymer suspended in an isotonic solution, where the cationic lipopolymer includes a cationic polymer backbone having cholesterol and polyethylene glycol covalently attached thereto, and wherein the molar ratio of cholesterol to cationic polymer backbone is within a range of from about 0.1 to about 10, and the molar ratio of polyethylene glycol to cationic polymer backbone is within a range of from about 0.1 to about 10. The composition further may include a filler excipient.Type: ApplicationFiled: September 25, 2015Publication date: August 25, 2016Applicant: CLSN Laboratories, Inc.Inventors: Majed MATAR, Jason Fewell, Danny H. Lewis, Khursheed Anwer
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Patent number: 9254334Abstract: Disclosed are compounds, compositions and methods for systemic and local delivery of biologically active molecules.Type: GrantFiled: December 18, 2014Date of Patent: February 9, 2016Assignee: CLSN Laboratories, Inc.Inventors: Gregory Slobodkin, Richard Congo, Majed Matar, Jason Fewell, Khursheed Anwer, Brian Jeffery Sparks
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Patent number: 9144546Abstract: Compositions, methods, and applications that increase the efficiency of nucleic acid transfection are provided. In one aspect, a pharmaceutical composition may include at least about 0.5 mg/ml concentration of a nucleic acid condensed with a cationic lipopolymer suspended in an isotonic solution, where the cationic lipopolymer includes a cationic polymer backbone having cholesterol and polyethylene glycol covalently attached thereto, and wherein the molar ratio of cholesterol to cationic polymer backbone is within a range of from about 0.1 to about 10, and the molar ratio of polyethylene glycol to cationic polymer backbone is within a range of from about 0.1 to about 10. The composition further may include a filler excipient.Type: GrantFiled: September 6, 2012Date of Patent: September 29, 2015Assignee: CLSN Laboratories, Inc.Inventors: Majed Matar, Jason Fewell, Danny H. Lewis, Khursheed Anwer
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Publication number: 20150099000Abstract: Disclosed are compounds, compositions and methods for systemic and local delivery of biologically active molecules.Type: ApplicationFiled: December 18, 2014Publication date: April 9, 2015Applicant: CLSN Laboratories, Inc.Inventors: Gregory SLOBODKIN, Richard Congo, Majed Matar, Jason Fewell, Khursheed Anwer, Brian Jeffery Sparks
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Patent number: 8932638Abstract: Disclosed are compounds, compositions and methods for systemic and local delivery of biologically active molecules.Type: GrantFiled: March 8, 2013Date of Patent: January 13, 2015Assignee: CLSN Laboratories, Inc.Inventors: Gregory Slobodkin, Richard Congo, Majed Matar, Jason Fewell, Khursheed Anwer, Brian Jeffery Sparks
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Patent number: 8900621Abstract: Disclosed are compounds, compositions and methods for systemic and local delivery of biologically active molecules.Type: GrantFiled: March 8, 2013Date of Patent: December 2, 2014Assignee: CLSN Laboratories, Inc.Inventors: Gregory Slobodkin, Richard Congo, Majed Matar, Jason Fewell, Khursheed Anwer, Brian Jeffery Sparks