Patents Assigned to CLSN Laboratories, Inc.
  • Publication number: 20180303957
    Abstract: Compositions, methods, and applications that increase the efficiency of nucleic acid transfection are provided. In one aspect, a pharmaceutical composition may include at least about 0.5 mg/ml concentration of a nucleic acid condensed with a cationic lipopolymer suspended in an isotonic solution, where the cationic lipopolymer includes a cationic polymer backbone having cholesterol and polyethylene glycol covalently attached thereto, and wherein the molar ratio of cholesterol to cationic polymer backbone is within a range of from about 0.1 to about 10, and the molar ratio of polyethylene glycol to cationic polymer backbone is within a range of from about 0.1 to about 10. The composition further may include a filler excipient.
    Type: Application
    Filed: November 27, 2017
    Publication date: October 25, 2018
    Applicant: CLSN Laboratories, Inc.
    Inventors: Majed MATAR, Jason FEWELL, Danny H. LEWIS, Khursheed ANWER
  • Patent number: 9827331
    Abstract: Compositions, methods, and applications that increase the efficiency of nucleic acid transfection are provided. In one aspect, a pharmaceutical composition may include at least about 0.5 mg/ml concentration of a nucleic acid condensed with a cationic lipopolymer suspended in an isotonic solution, where the cationic lipopolymer includes a cationic polymer backbone having cholesterol and polyethylene glycol covalently attached thereto, and wherein the molar ratio of cholesterol to cationic polymer backbone is within a range of from about 0.1 to about 10, and the molar ratio of polyethylene glycol to cationic polymer backbone is within a range of from about 0.1 to about 10. The composition further may include a filler excipient.
    Type: Grant
    Filed: September 25, 2015
    Date of Patent: November 28, 2017
    Assignee: CLSN Laboratories, Inc.
    Inventors: Majed Matar, Jason Fewell, Danny H. Lewis, Khursheed Anwer
  • Publication number: 20160331686
    Abstract: The present invention provides compositions of yeast extracellular vesicles comprising biologically active molecules, methods for making the same, and methods for the use of the yeast extracellular vesicles to deliver biologically active molecules to target cells. In addition, the invention provides cells and compositions comprising the biologically active molecules and vesicles, which can be used as transfection reagents. The invention further provides methods for producing said compositions of biologically active molecules with vesicles as well as the cells that produce those compositions. Compositions and methods for delivering biologically active molecules, such as a small molecule, a DNA expression plasmid, an RNA molecule, a peptide, or a protein, to cells and/or tissues are provided.
    Type: Application
    Filed: May 11, 2016
    Publication date: November 17, 2016
    Applicant: CLSN Laboratories, Inc.
    Inventors: Kevin J. POLACH, Daniel W. Neef, Jason G. Fewell, Khursheed Anwer
  • Publication number: 20160243256
    Abstract: Compositions, methods, and applications that increase the efficiency of nucleic acid transfection are provided. In one aspect, a pharmaceutical composition may include at least about 0.5 mg/ml concentration of a nucleic acid condensed with a cationic lipopolymer suspended in an isotonic solution, where the cationic lipopolymer includes a cationic polymer backbone having cholesterol and polyethylene glycol covalently attached thereto, and wherein the molar ratio of cholesterol to cationic polymer backbone is within a range of from about 0.1 to about 10, and the molar ratio of polyethylene glycol to cationic polymer backbone is within a range of from about 0.1 to about 10. The composition further may include a filler excipient.
    Type: Application
    Filed: September 25, 2015
    Publication date: August 25, 2016
    Applicant: CLSN Laboratories, Inc.
    Inventors: Majed MATAR, Jason Fewell, Danny H. Lewis, Khursheed Anwer
  • Patent number: 9254334
    Abstract: Disclosed are compounds, compositions and methods for systemic and local delivery of biologically active molecules.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: February 9, 2016
    Assignee: CLSN Laboratories, Inc.
    Inventors: Gregory Slobodkin, Richard Congo, Majed Matar, Jason Fewell, Khursheed Anwer, Brian Jeffery Sparks
  • Patent number: 9144546
    Abstract: Compositions, methods, and applications that increase the efficiency of nucleic acid transfection are provided. In one aspect, a pharmaceutical composition may include at least about 0.5 mg/ml concentration of a nucleic acid condensed with a cationic lipopolymer suspended in an isotonic solution, where the cationic lipopolymer includes a cationic polymer backbone having cholesterol and polyethylene glycol covalently attached thereto, and wherein the molar ratio of cholesterol to cationic polymer backbone is within a range of from about 0.1 to about 10, and the molar ratio of polyethylene glycol to cationic polymer backbone is within a range of from about 0.1 to about 10. The composition further may include a filler excipient.
    Type: Grant
    Filed: September 6, 2012
    Date of Patent: September 29, 2015
    Assignee: CLSN Laboratories, Inc.
    Inventors: Majed Matar, Jason Fewell, Danny H. Lewis, Khursheed Anwer
  • Publication number: 20150099000
    Abstract: Disclosed are compounds, compositions and methods for systemic and local delivery of biologically active molecules.
    Type: Application
    Filed: December 18, 2014
    Publication date: April 9, 2015
    Applicant: CLSN Laboratories, Inc.
    Inventors: Gregory SLOBODKIN, Richard Congo, Majed Matar, Jason Fewell, Khursheed Anwer, Brian Jeffery Sparks
  • Patent number: 8932638
    Abstract: Disclosed are compounds, compositions and methods for systemic and local delivery of biologically active molecules.
    Type: Grant
    Filed: March 8, 2013
    Date of Patent: January 13, 2015
    Assignee: CLSN Laboratories, Inc.
    Inventors: Gregory Slobodkin, Richard Congo, Majed Matar, Jason Fewell, Khursheed Anwer, Brian Jeffery Sparks
  • Patent number: 8900621
    Abstract: Disclosed are compounds, compositions and methods for systemic and local delivery of biologically active molecules.
    Type: Grant
    Filed: March 8, 2013
    Date of Patent: December 2, 2014
    Assignee: CLSN Laboratories, Inc.
    Inventors: Gregory Slobodkin, Richard Congo, Majed Matar, Jason Fewell, Khursheed Anwer, Brian Jeffery Sparks