Patents Assigned to CNRS-DIRE
  • CARBONIC ANHYDRASE INHIBITORS WITH ANTIMETASTATIC ACTIVITY
    Publication number: 20140148400
    Abstract: Derivatized coumarin-based pharmaceutical compositions and methods to use them are provided. The compositions are characterized in that they inhibit the activity of tumor-related CAIX and CAXII to a greater degree than they inhibit the activity of CAI and CAII. The compositions can be used to suppress tumor growth and/or suppress tumor metastases in a mammal.
    Type: Application
    Filed: November 12, 2013
    Publication date: May 29, 2014
    Applicants: METASIGNAL THERAPEUTICS INC., CNRS-DIRE, UNIVERSITE MONTPELLIER 2 SCIENCES ET TECHNIQUES
    Inventors: Claudiu Supuran, Shoukat Dedhar, Fabrizio Carta, Jean-Yves Winum, Paul C. McDonald