Abstract: The present invention relates to antibodies targeting Tumor Associated Macrophages (TAMs) and uses thereof. The inventors investigated specific marker exposed on the surface of the macrophages associated to tumor in order to detect and target TAMs. They showed that sideroflexin 3, which is absent in normal macrophage, is expressed by tumor associated macrophages. The inventors further demonstrated that using antibody directed to sideroflexin 3, they depleted TAMs in PBMC sample obtained from LCC patient, and strongly reduced leukemic B cells number.

Abstract: The invention relates to a method for labeling specifically living microorganisms in a sample comprising microorganisms, the method comprising the steps of: a) incubating said microorganisms of said sample with at least one modified monosaccharide compound comprising a first reactive chemical group capable to chemically react with a second reactive group, so that a residue bearing said first reactive group is incorporated into such microorganisms, and b) contacting said residue incorporated in the microorganisms, with a labeling molecule comprising a said second reactive group, for generating the chemical reaction of said first reactive group of said residue incorporated within said living microorganisms with said second reactive group of said labeling molecule, resulting in a covalent link, characterized in that the said modified monosaccharide compound has the following formula (I?), or a salt thereof: —X can be O, NH or S, preferably O and NH, and —R1 and R2 can be independently H, OH, NH2, OH and NH2 bein

Abstract: An object is to provide a component for molecular Computing and a method of molecular Computing. A component for molecular Computing, the component comprising: a microsphere including pores, at least some of which are open on a surface of the microsphere, and a plurality of modules grafted on the microsphere wherein each of the modules is a continuous séquence of nucleic acid base.

Abstract: Methods and systems are provided for decoding movement intentions using functional ultrasound (fUS) imaging of the brain. In one example, decoding movement intentions include determining a memory phase of a cognitive state of the brain, the memory phase between a gaze fixation phase and movement execution phase, and determining one or more movement intentions including one or more of intended effector (e.g., hand, eye) and intended direction (e.g., right, left) according to a machine learning algorithm trained to classify one or more movement intentions simultaneously.

Abstract: The present application relates to novel azetidinimine of formula (I). Wherein R1-R6 are as defined in claim 1. The azetidinimine of the invention are useful as antibiotics and as inhibitors of a carbapenemases. The present invention thus further relates to their use in antibiotic therapies and their methods of synthesis.

Abstract: According to one aspect, the invention relates to a system (101) for in vivo, full-field interference microscopy imaging of a scattering three-dimensional sample.

Abstract: A device for multispectral imaging in the infrared, suitable for detecting at at least one first and one second detection wavelength is provided. It comprises a detection matrix array comprising a set of elementary detectors of preset dimensions forming an image field of given dimensions; and an image-forming optic having a given aperture number (N) and a given focal length (F), which aperture number and focal length are suitable for forming, at any point of the image field, an elementary focal spot covering a set of at least two juxtaposed elementary detectors.

Abstract: The invention relates to a supercapacitor comprising: an electrolyte having a first end and a second end opposite the first end, a first electrode in contact with the first end of the electrolyte, and a second electrode in contact with the second end of the electrolyte. In particular, the electrolyte is made of a solid material that is ion-conductive and electronically insulating.

Abstract: A shielding element comprises a rigid substrate and at least one electrically conductive two-dimensional structure which is placed on one of the faces of the substrate. The substrate and the electrically conductive two-dimensional structure are such that the shielding element has optical-transmission and shielding-efficiency values at least one of which varies between two zones of the shielding element. Such a shielding element enables easier assembly of a detection system comprising multiple optical sensors.

Abstract: A process for preparing a polyaminoborane comprising reacting at least one monomer with an aminoborane, wherein the at least one monomer is selected from the group consisting of ammonia, a primary amine and a substituted or unsubstituted hydrazine; and wherein the aminoborane comprises a borane substituted by a secondary amino group; polyaminoboranes obtainable by said process; use of said polyaminoboranes for the preparation of a ceramic precursor or a ceramic, the production of boron nitride, or the storage and/or production of dihydrogen; ceramic precursors, ceramics, hydrogen cells or energy materials comprising said polyaminoboranes.

Abstract: An optical guide for a near-eye display device includes a first guide element having a light input zone and a second guide element having an output zone. The first guide element is superimposed on the second guide element. The optical guide also includes an optical coupling system between the first guide element and the second guide element, and the first and second guide elements have, on the first part of their length, a mutual spacing so as to delimit a thin layer of air between said guide elements extending between a first longitudinal end of the guide elements and the optical coupling system. The optical coupling system, located at a second longitudinal end of the first and second guide elements, includes a single-piece portion of the guide elements, associated with an optical reflection member to propagate the beams of light from the input zone toward the output zone.

Abstract: The present invention generally relates to an immunogenic construct, useful for redirecting an EBV-existing immune response towards an undesired target cell and/or microorganism, to methods for preparing said conjugate, to a pharmaceutical applications comprising said conjugate, and to medical applications thereof.

Abstract: In order to obtain a predetermined ultrasonic wave field in a homogeneous internal part of a medium masked by an aberrating barrier, an ultrasonic lens is interposed between the emitting ultrasonic probe and the aberrating barrier. The ultrasonic lens is calculated by using a model of the medium comprising a mapping of ultrasonic wave propagation properties obtained from actual imaging of the medium such that when the ultrasound probe sends a predetermined ultrasonic wave, said predetermined wave generates the predetermined objective ultrasonic wave field in the medium.

Abstract: The present invention improves the quality of the magnitude and phase images produced in medical imaging, in particular in the case of multi-antenna MRI. The invention proposes to generate (28) such an image (I) by summing the complex image data (pj,{tilde over (p)}j) obtained from different antennas by weighting these data using only the diagonal elements (Rj,j) of an antenna noise covariance matrix or its inverse or pseudo-inverse matrix (Rj,j?1). A reference antenna (Ref) may be determined (24), so as to be able to replace (26), in each of these datum, a phase component specific to the acquisition antenna by a reference phase component. The reference antenna is preferably a virtual antenna formed by linear combination of the antennas of the MRI system. If significant improvements are obtained in the phase image resulting from the summation, a very clear gain is also surprisingly obtained in the magnitude image.

Abstract: The invention relates to a tablet or capsule containing a plant extract, to assist in the treatment or prevention of disorders or diseases. The tablet or capsule includes bioconverted products provided by fermenting Withania Somnifera extract, Emblica officinalis extract, and Bacopa monnieri extract.

Abstract: The invention concerns a method for calibrating a system for real-time measurement of the activity of a cognitive function of a test subject, the method comprising the successive steps of: acquiring electrical signals representative of a neural activity of a test subject; calculating values of markers of the cognitive function activity; generating a plurality of copies of calculated values of markers and adding noise to the generated copies; and, constructing a classifier by machine learning, based on the calculated marker values and noisy copies, the classifier being suitable for measuring the activity of the cognitive function of the test subject by calculating a probability that an electrical signal representative of the neural activity of the test subject results from a predetermined activity state of the cognitive function of the test subject.

Abstract: The disclosure relates to benzoimidazole derivatives, acting as anticancer drugs, as well as pharmaceutical composition containing said compounds. These compounds are able to firstly inhibit the protein/protein interactions of the MAP Kinase Erk, leading to inhibition of proliferation and secondly to induce apoptosis in human cancer cell lines.

Abstract: The present invention relates to variable domains of a camelid heavy-chain antibodies directed against a phosphorylated tau protein and conjugates thereof. The present invention also relates to the use of these domains or conjugates for treating or diagnosing disorders mediated by neurofibrillary tangles, neuropil threads or dystrophic neurites, such as tauopathies.

Abstract: A treatment system for stimulating the vagus nerves is described, comprising the following elements: —a detection and control unit (20); —at least one detection probe (10d, 10g) connected to the detection and control unit and intended to be applied to at least one of the two vagus nerves of a patient; —means (24) provided in the detection and control unit for detecting a phenomenon of mass discharge of action potentials in at least one vagus nerve using the detection probe or detection probes; —stimulation probes (10d, 10g) for stimulating vagus nerves, and—means (24) provided in the detection and control unit that are capable, in response to the detection of a mass discharge, of applying predefined asymmetric stimulation signals to said stimulation probes capable of causing a depolarization and/or hyperpolarization of the vagus nerves and of blocking the conduction of the action potentials at least in the efferent direction.

Abstract: This invention relates to the direct grafting of a calixarene mostly onto the surface of a material, as well as to a grafting process, and certain calixarene intermediates useful for carrying the grafting process.