Patents Assigned to CNRS
  • Methods and pharmaceutical compositions for the treatment of pulmonary bacterial infections
    Patent number: 10954299
    Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of pulmonary bacterial infections. The increasing burden of antimicrobial resistance coupled with the decreasing number of antibiotics in development has urged for strategies to elaborate new therapies. The inventors showed a therapeutic effect of IL-20 receptor 10 antagonists in pulmonary bacterial infection mouse model. Indeed, they demonstrated that treatment with IL-20 receptor antagonists reduces bacterial burden, cellular infiltration and inflammation in bronchoalveolar lavage fluid (BALF) and lung. In particular, the present invention relates to an antagonist of IL-20 cytokines, or/and an antagonist of IL-20RB receptor for use in a method for the treatment of pulmonary bacterial infections in a subject in 15 need thereof.
    Type: Grant
    Filed: May 24, 2017
    Date of Patent: March 23, 2021
    Assignees: INSERM (Institut National de la Santé et de la Recherche Médicale), Centre National de la Recherche Scientifique (CNRS), Institut Paseur de Lille, Universitéde Lille
    Inventors: Philippe Gosset, Fahima Madouri, Muriel Pichavant
  • COMPOUNDS FOR TREATING NEURODEGENERATIVE DISORDERS
    Publication number: 20210079035
    Abstract: Compounds for treating neurodegenerative disorders The invention relates to compounds of formula (I), their method of synthesis as well as their use to treat neurodegenerative disorders.
    Type: Application
    Filed: December 11, 2017
    Publication date: March 18, 2021
    Applicants: ETHNODYNE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Chérif Rabhi, Léon Cariel, Christian Da Costa Noble, Jamal Ouazzani, Guillaume Arcile, Géraldine Le Goff
  • Peptides of use in the preventive and curative treatment of alopecia
    Patent number: 10947273
    Abstract: The object of the present invention relates to a novel family of peptide conjugates of formula (I): A-X1-X2-Pro-Ala-X—B??(I) wherein: A represents a hydrogen atom, a C6 to C20 acyl group or a cholesterol residue; X1 represents a covalent bond, an alanine or a proline; X2 represents an arginine, a lysine, or an alanine; X represents a lysine, an alanine, or a phenylalanine; and B represents a hydroxyl or an amine; or one of its preferentially pharmaceutically, dermatologically or cosmetically acceptable salts, as well as their synthesis processes and their uses for reducing hair loss and stimulating hair growth.
    Type: Grant
    Filed: October 10, 2016
    Date of Patent: March 16, 2021
    Assignees: Institut European de Biologic Cellulaire, Centre de Recherches Biologiques et d'Experimentations Cutanees, Centre National de la Recherche Scientifique (CNRS)
    Inventors: Michel Hocquaux, Stéphanie Almeida Épouse Scalvino, Elian Lati, Joanna Bakala
  • LIQUID LENSES WITH CERAMIC INSULATING LAYERS
    Publication number: 20210072431
    Abstract: A liquid lens that includes a first window, a second window, and a cavity disposed between the first window and the second window; a first and second liquid disposed within the cavity, the first and second liquid substantially immiscible with each other and having different refractive indices such that an interface between the first and second liquid defines a variable lens, at least a portion of the first liquid disposed within a first portion of the cavity, the second liquid disposed within a second portion of the cavity; a common electrode in electrical communication with the first liquid; and a driving electrode disposed on a sidewall of the cavity and insulated from the first liquid and the second liquid by an insulating element, wherein the insulating element comprises an insulating outer layer in contact with the liquids, the insulating outer layer comprising a lanthanide series oxide.
    Type: Application
    Filed: December 13, 2018
    Publication date: March 11, 2021
    Applicants: CORNING INCORPORATED, UNIVERSITE CLAUDE BERNARD LYON 1, Centre National De La Recherche Scientifique-CNRS
    Inventors: Bruno Berge, Gwenael Bonfante, Benjamin Burger, Stéphanie Chevalliot, Mathieu Maillard, Bérangère Toury-Pierre
  • PHASE CHANGE OPTICAL DEVICE
    Publication number: 20210071083
    Abstract: An optical device including an aerogel located in an encapsulating structure, an optically non isotropic material presenting a refractive index which can be changed upon submitting said material to an electrical field, preferentially a liquid crystal mixture, embedded in the aerogel, and first and second electrodes arranged to generate an electric field in the encapsulating structure.
    Type: Application
    Filed: January 29, 2019
    Publication date: March 11, 2021
    Applicants: Essilor International, UNIVERSITE DE MONTPELLIER, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE- CNRS
    Inventors: Samuel ARCHAMBEAU, Claudine BIVER, Pascal ETIENNE, Sylvie CALAS ETIENNE, Laurent BONNET
  • COMPOUNDS FOR TREATING NEURODEGENERATIVE DISORDERS
    Publication number: 20210070799
    Abstract: The invention relates to compounds of formula (I), their method of synthesis as well as their use to treat neurodegenerative disorders.
    Type: Application
    Filed: December 11, 2017
    Publication date: March 11, 2021
    Applicants: ETHNODYNE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Chérif Rabhi, Léon Cariel, Christian Da Costa Noble, Jamal Ouazzani, Guillaume Arcile, Géraldine Le Goff
  • Printing an adhesive pattern on an anti-fouling support
    Patent number: 10941319
    Abstract: Process for printing an adhesive pattern on a polymer brush extending at the surface of a support (1), forming a nanometric anti-fouling layer (2), the process comprising the following steps: —placing the layer (2) in contact with a first aqueous solution (4) containing a benzophenone, —then illuminating the layer with radiation (3) at a wavelength within the absorption spectrum of benzophenone, according to the pattern and according to a surface energy.
    Type: Grant
    Filed: October 2, 2015
    Date of Patent: March 9, 2021
    Assignees: ALVEOLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, UNIVERSITÉ DE BORDEAUX
    Inventor: Vincent Studer
  • MATERIALS WITH HIGH DIELECTRIC CONSTANT FOR MAGNETIC RESONANCE IMAGING INSTRUMENTS
    Publication number: 20210063511
    Abstract: The invention relates to a material for use as a pad in high field and/or very high field magnetic resonance imaging instrument, comprising at least one polar solvent having a melting point of 14° C. to 50° C., a dispersant and a dielectric charge. The invention relates also to a pad used in field of high field and/or very high field magnetic resonance imaging made of at least such a material.
    Type: Application
    Filed: March 27, 2019
    Publication date: March 4, 2021
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, ECOLE CENTRALE DE MARSEILLE, UNIVERSITE D'AIX-MARSEILLE (AMU)
    Inventors: Abdeddaim Redha, Anne-Lise Adenot-Engelvin, Marc Dubois, Stefan Enoch, Nicolas Mallejac, Zo Raolison, Pierre Sabouroux, Alexandre Vignaud
  • Magnetic tunnel junction with perpendicular shape anisotropy and minimised variability, memory point and logic element including the magnetic tunnel junction, method for manufacturing the magnetic tunnel junction
    Patent number: 10930841
    Abstract: A magnetic tunnel junction with out-of-plane magnetisation includes a storage layer; a reference layer; a tunnel barrier layer, the two magnetisation states of the storage layer being separated by an energy barrier, the magnetic tunnel junction having a thermal stability factor dependent on the energy barrier and on the temperature of use of the magnetic tunnel junction. The storage layer has a thickness comprised between 0.5 times and 8 times a characteristic dimension of a planar section of the tunnel junction; the composition and the thickness of the storage layer are chosen such that the absolute value of the derivative of the thermal stability factor compared to a characteristic dimension of a planar section of the tunnel junction is less than 10 nm?1.
    Type: Grant
    Filed: February 22, 2019
    Date of Patent: February 23, 2021
    Assignees: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT POLYTECHNIQUE DE GRENOBLE
    Inventors: Nicolas Perrissin-Fabert, Bernard Dieny, Lucian Prejbeanu, Ricardo Sousa
  • Cationic siRNAs, synthesis and use for RNA interference
    Patent number: 10927371
    Abstract: The invention relates to cationic siRNAs, characterized in that they are double-stranded RNA fragments, grafted to the ends of which are oligocations, the number of cationic charges grafted being comparable to or greater than that of the anionic charges carried by the internucleoside phosphates of the RNA strands.
    Type: Grant
    Filed: January 30, 2009
    Date of Patent: February 23, 2021
    Assignees: Centre National De La Recherche Scientifique (CNRS), Universite De Strasbourg, Pollyplus Transfection
    Inventors: France Jean-Paul Behr, Mitsuharu Kotera, Nadege Pfender, Jean-Serge Remy
  • HYDROGEL COMPOSITES COMPRISING CHITOSAN AND CELLULOSE NANOFIBERS
    Publication number: 20210047479
    Abstract: The present invention relates to an aqueous or hydro-alcoholic suspension of chitosan, dispersed cellulose nanofibers, and an acid, which is suitable for obtaining a hydrogel composite comprising a network of chitosan and cellulose nanofibers. The suspension of the invention is useful for tissue regeneration and the hydrogel of the invention is useful as bioresorbable and biocompatible implant.
    Type: Application
    Filed: March 13, 2019
    Publication date: February 18, 2021
    Applicants: Albert-Ludwigs-Universitaet Freiburg, Université Claude Bernard Lyon 1, Centre National de la Recherche Scientifique - CNRS, Institut Enseignement Supérieur et Recherche en Alimentation Santé Animals Sciences Agronomiques et
    Inventors: Anayancy OSORIO MADRAZO, Laurent DAVID, Alexandra MONTEMBAULT, Eric VIGUIER, Thibaut CACHON
  • Selective bromodomain inhibition of fungal Bdf1
    Patent number: 10918647
    Abstract: The invention provides antifungal compounds, antifungal compositions, and intermediates for the preparation of antifungal compounds and antifungal compositions. The invention also provides methods of inhibiting fungi and methods of treating fungal infections, for example, with a compound or composition described herein. The antifungal compositions can include antifungal adjuvants such as essential oils or essential oil extracts, which adjuvants further improve the antifungal activity of the compositions.
    Type: Grant
    Filed: July 26, 2017
    Date of Patent: February 16, 2021
    Assignees: University of Southern California, CNRS, Universite Grenoble Alpes, INSERM
    Inventors: Charles E. McKenna, Carlo Petosa, Jerome Govin, Boris A. Kashemirov, Elena Ferri, Flore Mietton
  • Device and method for inducing by thermal poling a spatially controlled refractive index gradient inside an amorphous inorganic material
    Patent number: 10919801
    Abstract: A device for inducing by thermal poling a spatially controlled refractive index gradient inside at least one amorphous inorganic material to be treated, includes a structured electrode arranged on the surface or in proximity to the surface of the material to be treated; and at least one dielectric material. The structured electrode includes at least one conductive zone and at least one non-conductive zone and it is confined between the amorphous inorganic material to be treated and the dielectric material.
    Type: Grant
    Filed: June 27, 2017
    Date of Patent: February 16, 2021
    Assignees: UNIVERSITE DE BORDEAUX, INSTITUT POLYTECHNIQUE DE BORDEAUX, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC
    Inventors: Marc Dussauze, Antoine Lepicard, Flavie Marie Bondu, Vincent Jean-Paul Rodriguez, Frédéric Adamietz, Thierry Cardinal, Evelyne Claude Fargin, Kathleen Richardson
  • Method for adjusting the level of inhibitors in an oil or gas well
    Patent number: 10920534
    Abstract: A method for adjusting, to a pre-determined value, the level of a mineral deposition or corrosion inhibitor injected into a gas or oil well. Using of the time-resolved fluorescence method for detecting and quantifying a mineral deposition or corrosion inhibitor in a fluid from an oil or gas production well.
    Type: Grant
    Filed: May 10, 2019
    Date of Patent: February 16, 2021
    Assignees: TOTAL SA, UNIVERSITE LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFQUE—CNRS
    Inventors: Christian Hurtevent, Salima Baraka-Lokmane, John-Richard Ordonez-Varela, Olivier Tillement, Thomas Brichart, Mattéo Martini
  • Delta133p53beta and delta133p53gamma isoforms are biomarkers of cancer stem cells
    Patent number: 10920198
    Abstract: The present invention is in the field of oncology, and more particularly of cancer stem cells. It relates to a method for producing cancer stem cells based on overexpression of ?133?536 isoform, ?133?53? isoform, or both ?133?536 and ?133?53? isoforms; a method for predicting the risk that treatment with a chemotherapeutic anti-cancer agent induces cancer stem cells in a subject suffering from cancer from a cancer sample of said subject, based on detection of an increase in ?133?536 isoform, ?133?53? isoform, or both ?133?536 and ?133?53? isoforms following chemotherapeutic anti-cancer treatment; to therapeutic uses of a combination of chemotherapeutic anti-cancer agent and an agent reducing ?133p536 isoform, ?133?53? isoform, or both ?133?536 and ?133?53? isoforms expression; and also to screening methods for anti-cancer stem cells agents.
    Type: Grant
    Filed: February 1, 2016
    Date of Patent: February 16, 2021
    Assignees: Centre National de la Recherche Scientifique (CNRS), Universite de Montpellier
    Inventors: Pierre Roux, Nikola Arsic, Gilles Gadea, Philippe Fort, Fanny Thomas, Véronique Gire
  • MODULATORS OF SMALL CONDUCTANCE CALCIUM ACTIVATED K+ CHANNELS AND PHARMACEUTICAL COMPOSITIONS FOR USE IN THE TREATMENT OF LESIONAL VESTIBULAR DISORDERS
    Publication number: 20210038682
    Abstract: The invention relates to a modulator of small conductance calcium activated K+ channels of the vestibular nuclei cells for use in the treatment of a lesional vestibular disorder in a patient in need thereof, and to a pharmaceutical composition comprising such modulator, for such a use.
    Type: Application
    Filed: March 13, 2019
    Publication date: February 11, 2021
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE D'AIX-MARSEILLE (AMU)
    Inventors: Brahim Tighilet, Christian Chabbert, Christiane Mourre, David Pericat, Jacques Léonard
  • Pseudomonas aeruginosa inhibitor compounds
    Patent number: 10908153
    Abstract: The invention relates to a method of identifying molecules which inhibit the virulence machinery of Pseudomonas aeruginosa, to a device for identifying a molecule which inhibits the virulence machinery of Pseudomonas aeruginosa, to novel compounds which inhibit the virulence machinery of Pseudomonas aeruginosa, to compounds for use for preventing and/or treating a pathogenic infection caused by Pseudomonas aeruginosa and also to pharmaceutical compositions for preventing and/or treating a pathogenic infection caused by Pseudomonas aeruginosa.
    Type: Grant
    Filed: July 12, 2016
    Date of Patent: February 2, 2021
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), COMMISSARIAT À L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES
    Inventors: Yung-Sing Wong, Sophie Ple, Ina Attree, Caroline Barette
  • DEVICES AND METHODS FOR CONVEYING AND CONTROLLING LIGHT BEAMS FOR LENSLESS ENDO-MICROSCOPIC IMAGERY
    Publication number: 20210018744
    Abstract: According to one aspect, the invention relates to a device for transporting and controlling light beams for endo-microscopic imaging without a lens on the distal side comprising a single-mode optical fibre bundle (40) on the distal side, wherein each single-mode optical fibre is intended to receive an elementary light source and to emit a light beam at a distal end; a single-mode optical fibre section (50) arranged at the distal end of the optical fibre bundle and intended to receive the light beams emitted by the single-mode optical fibres of the optical fibre bundle; an optical phase control device arranged on the side of the proximal end of the single-mode optical fibres.
    Type: Application
    Filed: April 4, 2017
    Publication date: January 21, 2021
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS, Universite d'Aix-Marseille (AMU), Ecole Centrale de Marseille (ECM)
    Inventors: Hervé Rigneault, Esben Ravn Andresen, Siddarth Sivankutty
  • METHOD FOR FORMING SPACERS OF A TRANSISTOR
    Publication number: 20210013040
    Abstract: A method for forming spacers on a gate pattern includes deposition of a first dielectric layer having basal portions on an active layer and side portions of the edges of the pattern; anisotropic modification of only the basal portions of the first layer, so as to obtain modified basal portions; deposition of a second dielectric layer on the first layer, also having basal and side portions; anisotropic etching of only the basal portions of the second layer, so as to remove these basal portions while conserving the side portions; and removal of the modified basal portions while conserving the first and second non-modified side portions, by selective etching of the modified dielectric material vis-à-vis the non-modified dielectric material.
    Type: Application
    Filed: July 10, 2020
    Publication date: January 14, 2021
    Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE GRENOBLE ALPES
    Inventors: Nicolas POSSEME, Marceline BONVALOT, Ahmad CHAKER, Christophe VALLEE
  • Polymer composition comprising crosslinked silicones with exchangeable crosslinking points, preparation method and uses
    Patent number: 10889715
    Abstract: The invention relates to a silicone composition comprising (a) crosslinked polymers comprising consecutive —Si—O— units containing exchangeable pendant bonds and exchangeable crosslinking points, that are exchangeable by aldehyde-imine exchange reactions and/or by imine-imine exchange reactions and/or by imine-primary amine exchange reactions, obtained by crosslinking linear or branched polymers comprising consecutive —Si—O— units and (b) monofunctional free aldehydes and/or monofunctional free imines and/or monofunctional free primary amines.
    Type: Grant
    Filed: April 18, 2017
    Date of Patent: January 12, 2021
    Assignees: ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Ludwik Leibler, Renaud Nicolay, Corinne Soulie-Ziakovic