Abstract: An orthosis (1) for a lower extremity of a wearer, in particular for a foot and a lower leg of a wearer, preferably for wearers with diabetic foot syndrome or a neuropathic osteoarthropathy relating to the foot, comprising: a first orthosis part (2) which is to be arranged or which can be arranged on a lower leg of a wearer, a second orthosis part (3) which is to be arranged or which can be arranged on a foot of a wearer, and a third orthosis part (4) which connects the first and second orthosis part to one another, wherein at least one of the orthosis parts (2-4) has a geometric-constructive design, at least in portions, possibly completely, which is individually configured on the basis of data describing a foot and/or a lower leg of a wearer.