Abstract: The invention provides compositions and methods for preventing undesired immune responses in which a recombinant protein is prepared which includes a glycine-containing amino acid sequence, protein substantial invisibility to the immune system.
Abstract: The invention is based on the discovery of a pharmaceutical preparation for use in gene therapy which includes a therapeutic nucleic acid associated with Insulin-NHCO--CH.sub.2 --O--N.dbd.CH--C-Lys.sub.18 -Cys(S-Pyridyl)-OH in combination with a pharmaceutically acceptable carrier.
Type:
Grant
Filed:
December 18, 1996
Date of Patent:
November 3, 1998
Assignee:
Cobra Therapeutics, Ltd.
Inventors:
David R. Thatcher, Robin E. Offord, Keith Rose, Hubert F. Gaertner