Abstract: A therapeutic and/or cosmetic formulation comprising at least one anti-sense polynucleotide to a connexin protein together with a pharmaceutically acceptable carrier or vehicle is useful in site specific down regulation of connexin protein expression, particularly in reduction of neuronal cells death, wound healing, reduction of inflammation, decrease of scar formation and skin rejuvenation and thickening.
Type:
Grant
Filed:
January 27, 2000
Date of Patent:
August 29, 2006
Assignee:
CoDa Therapeutics Ltd.
Inventors:
David Laurence Becker, Colin Richard Green