Patents Assigned to Codman & Shurtleff
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Patent number: 8383865Abstract: The present invention is directed to a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (I) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (I) and its therapeutic use.Type: GrantFiled: September 30, 2009Date of Patent: February 26, 2013Assignee: Codman & Shurtleff, Inc.Inventor: Thomas M. DiMauro
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Patent number: 8366720Abstract: An interventional medical device system operable while within a body vessel is provided with a generally hollow tubular proximal portion, distal portion, and intermediate portion. The proximal portion and at least part of the distal portion remains outside of the body in use, with the remainder of the distal portion positioned within the body. The intermediate portion includes a spiral ribbon having adjacent turns, with at least one frangible bridge member between two adjacent turns. The proximal and distal portions are movable away from each other by elongating the spiral ribbon and, eventually, breaking the frangible bridge member. According to a method of using such a system to deploy an implantable medical device, such as an embolic coil, an actuation member is moved proximally with the proximal portion to disengage a bond or joint between the actuation member and the implantable medical device.Type: GrantFiled: July 31, 2006Date of Patent: February 5, 2013Assignee: Codman & Shurtleff, Inc.Inventors: Vladimir Mitelberg, John H. Thinnes, Jr., Keith Balgobin, William W. Sowers
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Patent number: 8361104Abstract: A vascular occlusion device that includes a central support member that has at least one mesh embolic ribbon extending outwardly from the central support member in the generally radial direction is provided. The mesh embolic ribbon has a collapsed and an expanded configuration.Type: GrantFiled: September 16, 2005Date of Patent: January 29, 2013Assignee: Codman & Shurtleff, Inc.Inventors: Donald K. Jones, Robert R. Slazas, Frederick R. Feller, III
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Patent number: 8357180Abstract: Thin film metallic devices implantable within a human subject for occlusion of an aneurysm or blood vessel are provided. The devices are movable from a porous, elongated, collapsed configuration for delivery to a deployed configuration within the body. The pores telescope as the device moves to its deployed configuration, which causes the device to longitudinally foreshorten and radially expand, while also decreasing in porosity for preventing blood flow. The occlusion devices may be either self-supporting or supported by a strut structure. Additionally, the occlusion devices may comprise a plurality of layers having unaligned pore systems which further reduce porosity in the deployed configuration.Type: GrantFiled: September 16, 2005Date of Patent: January 22, 2013Assignee: Codman & Shurtleff, Inc.Inventors: Frederick R. Feller, III, Juan A. Lorenzo
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Patent number: 8353857Abstract: An implantable medical device that includes a housing, a valve disposed within the housing, a first pressure sensor disposed within the housing upstream of the valve, and a second pressure sensor disposed within the housing downstream of the valve. A CPU is disposed within the housing and is electrically connected to the first pressure sensor and the second pressure sensor. To communicate the measured pressure information to an external device, the CPU compares the pressure measured by the first pressure sensor to the pressure measured by the second pressure sensor and wirelessly communicates these compared pressures to an external device. Alternatively, the CPU may wirelessly communicate the absolute value of the pressure measured by the first pressure sensor and the second pressure sensor to the external device. Additionally, the CPU and sensors may be non-invasively powered using optical or acoustical methods.Type: GrantFiled: June 23, 2003Date of Patent: January 15, 2013Assignee: Codman & Shurtleff, Inc.Inventor: Meir Rosenberg
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Patent number: 8350093Abstract: Methylated curcumin-methoxystilbene hybrid molecules that have particular use in treating cancer.Type: GrantFiled: May 13, 2010Date of Patent: January 8, 2013Assignee: Codman & Shurtleff, Inc.Inventor: Thomas M. DiMauro
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Publication number: 20130006345Abstract: Use of an interventional medical device system operable while within a body vessel is provided with a generally hollow tubular proximal portion, distal portion, and intermediate portion. The proximal portion and at least part of the distal portion remains outside of the body in use, with the remainder of the distal portion positioned within the body. The intermediate portion includes a spiral ribbon having adjacent turns, with at least one frangible bridge member between two adjacent turns. The proximal and distal portions are movable away from each other by elongating the spiral ribbon and, eventually, breaking the frangible bridge member. According to the method of using such a system to deploy an implantable medical device, such as an embolic coil, an actuation member is moved proximally with the proximal portion to disengage a bond or joint between the actuation member and the implantable medical device.Type: ApplicationFiled: September 10, 2012Publication date: January 3, 2013Applicant: Codman & Shurtleff, Inc.Inventors: Vladimir Mitelberg, John H. Thinnes, JR., Keith Balgobin, William W. Sowers
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Patent number: 8322365Abstract: A valve unit capable of being implanted in a patient and having adjustable performance settings, such as pressure settings and/or flow control, to regulate passage of a bodily fluid. A casing defines a port for the bodily fluid, and a valve mechanism positioned at the port includes a movable valve member. The valve unit further includes a rotor disposed at a first location in the casing and having an axle which turns about an axis of rotation. The rotor defines a plurality of arcuate, radially flat cam surfaces. Each cam surface occupies an arc about the axis of rotation. A spring arm unit is disposed at a second location in the casing having a cam follower arm in slidable contact with the cam surfaces of the rotor and having a resilient spring element applying a closing effect with the movable valve member to establish a performance setting for the valve unit.Type: GrantFiled: August 17, 2010Date of Patent: December 4, 2012Assignee: Codman & Shurtleff, Inc.Inventors: Stephen F. Wilson, Michael DeFusco
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Patent number: 8313442Abstract: A system and method for monitoring cerebral compliance of a patient by placing a first pressure sensor in a first sub-dural location, preferably a sub-meningeal location, within the brain of the patient and placing at least a second pressure sensor in a second sub-dural location, preferably a sub-meningeal location, within the brain which is different from the first location. At least one parameter from each of the signals derived from the pressure sensors is compared to estimate cerebral compliance for the patient. Alternatively, at least a single pressure sensor is utilized with a generator of reference signals having at least two different frequencies. Preferably, any change in cerebral compliance is detected by determining a change in the compared parameter, and a perceptible indication is generated when cerebral compliance deviates beyond a pre-selected value.Type: GrantFiled: November 25, 2009Date of Patent: November 20, 2012Assignee: Codman & Shurtleff, Inc.Inventor: Salim Kassem
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Patent number: 8308781Abstract: A cranial bolt secured to a skull of a patient includes a threaded portion and a lumen portion. Threaded portion has an inner surface forming a central passageway which extends throughout the threaded portion. The inner surface includes a connector mating with the lumen portion. The lumen portion includes a stem portion that enters the central passageway and engages the mating connector. A fluid tight seal is formed between the inner surface of the threaded portion and the stem portion. At least two lumens are disposed through the stem portion and the base portion. The lumens have a proximal end opening outside the skull and a distal end opening inside the skull. One embodiment includes sensor lumens diverging from the centerline and another allows the lumen portion to rotate independent of the threaded portion.Type: GrantFiled: September 9, 2009Date of Patent: November 13, 2012Assignee: Codman & Shurtleff, Inc.Inventors: Stephen F. Wilson, Michael C. Gorhan
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Patent number: 8288444Abstract: A device for iontophoretically delivering a charged curcuminoid across the skin of an Alzheimer's Disease patient.Type: GrantFiled: June 29, 2011Date of Patent: October 16, 2012Assignee: Codman & Shurtleff, Inc.Inventors: Sean Lilienfeld, Thomas M DiMauro
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Patent number: 8282566Abstract: A pressure sensing catheter having a pressure sensor and an antenna that is coupled to the pressure sensor, e.g., by a connector, are provided. The pressure sensor can be adapted to measure a pressure surrounding the catheter, and the antenna can be adapted to telemetrically communicate the measured pressure to an external device. In an exemplary embodiment, the antenna, pressure sensor, and/or connector are hermetically sealed, e.g., by the catheter and/or a coating, to prevent the antenna, pressure sensor, and connector from coming into contact with fluid, thereby allowing the catheter to be permanently implanted or otherwise used for long term use. Exemplary methods for manufacturing and using pressure sensing catheters are also provided.Type: GrantFiled: March 31, 2008Date of Patent: October 9, 2012Assignee: Codman & Shurtleff, Inc.Inventors: Christophe Mauge, Alan Dextradeur, Daniel McCusker, Stefan Meyer, Volker Boedecker, Robert G. Kraus, Max G. Ostermeier
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Publication number: 20120253381Abstract: A stretch-resistant occlusive device having an elongated, substantially cylindrical porous elastomeric structure and at least one of an elongated stretch-resistant tube and at least one stretch-resistant filament. The porous structure lies within an elongated outer embolic structure such as a helically wound embolic coil.Type: ApplicationFiled: March 31, 2011Publication date: October 4, 2012Applicant: Codman & Shurtleff, Inc.Inventors: PETER FORSYTHE, JUAN LORENZO
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Publication number: 20120253377Abstract: An occlusive device suitable for endovascular treatment of an aneurysm in a region of a parent vessel in a patient, including a structure having a fixed porosity and having dimensions suitable for insertion into vasculature of the patient to reach the region of the aneurysm in the parent vessel. The device further includes a frangible material supported by the structure which initially provides a substantial barrier to flow through the frangible material and is capable of at least one of localized rupturing and localized eroding, in the presence of a pressure differential arising at an ostium of a perforator vessel communicating with the parent vessel, within an acute time period to minimize ischemia downstream of the perforator vessel.Type: ApplicationFiled: March 31, 2011Publication date: October 4, 2012Applicant: CODMAN & SHURTLEFF, INC.Inventors: Robert Slazas, Juan Lorenzo, Peter Forsythe
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Patent number: 8252744Abstract: Methods and compositions are provided for suppressing appetite by surgically implanting a drug infusion pump into a site in a subject, and delivering a stable suspension of an appetite suppressing agent a region in a central nervous system of the subject. The appetite suppressing agent binds to a target receptor on a neural cell in the central nervous system and modifies the receptor function to suppress appetite.Type: GrantFiled: February 22, 2010Date of Patent: August 28, 2012Assignee: Codman & Shurtleff, Inc.Inventors: Vedrana Stojanovic-Susulic, Ramakrishna Venugopalan, Mark Cunningham
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Patent number: 8221392Abstract: This invention relates to achieving or improving uniform distribution of fluid flow in medical devices such as when combined with antibiotics impregnated in a catheter and/or with a drug-eluting catheter to further inhibit the catheter from becoming occluded by debris in the CSF or by bacterial biofilm formation or tissue proliferation in the catheter.Type: GrantFiled: October 31, 2007Date of Patent: July 17, 2012Assignee: Codman & Shurtleff, Inc.Inventors: Alan Dextradeur, Christophe Mauge
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Patent number: 8216292Abstract: A vascular occlusion device deployment system for placing an occlusion device at a preselected site within the vasculature of a patient. The deployment system employing a pusher having a lumen with an opening at the distal end of the pusher. A vascular occlusion device is connected to the distal end of the pusher by a portion that is removeably disposed within the opening. The portion of the occlusion device is forced out of the opening by an expandable reaction chamber, thereby deploying the occlusion device. The expandable reaction chamber, prior to deployment, has multiple chambers separated by a heat-dissolvable membrane. When the membrane is dissolved, components from the chambers react and expand, leading to deployment.Type: GrantFiled: June 30, 2009Date of Patent: July 10, 2012Assignee: Codman & Shurtleff, Inc.Inventors: Marc W. Litzenberg, Donald K. Jones, Vladimir Mitelberg
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Patent number: 8211141Abstract: A vasoocclusive embolic delivery system for use in placement of an embolic coil at a treatment site within a vessel. The embolic coil includes an elongated stretch resistant fiber having its distal end bonded to the distal end of the embolic coil. The stretch resistant fiber extends through a central lumen of the coil and extends beyond the proximal end of the coil. Also included is a generally cylindrical stabilization bead, having a diameter slightly smaller than the diameter of the central lumen of the coil, mounted on the stretch resistant fiber within the lumen of the embolic coil. The stabilization bead serves to keep the stretch resistant fiber centered within the lumen of the embolic coil. Additionally, a headpiece is mounted on the proximal end of the stretch resistant fiber and serves to couple the embolic coil to the delivery system.Type: GrantFiled: December 21, 2009Date of Patent: July 3, 2012Assignee: Codman & Shurtleff, Inc.Inventors: Richard Champion Davis, III, Todd E. Goede, David A. Kilmer
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Patent number: 8206413Abstract: A vascular occlusion device deployment system for placing an occlusion device at a preselected site within the vasculature of a patient. The deployment system employing a pusher having a lumen with an opening at the distal end of the pusher. A vascular occlusion device is connected to the distal end of the pusher by a portion that is removeably disposed within the opening. The portion of the occlusion device is forced out of the opening by an expandable reaction chamber, thereby deploying the occlusion device.Type: GrantFiled: July 19, 2010Date of Patent: June 26, 2012Assignee: Codman & Shurtleff, Inc.Inventors: Donald K. Jones, Vladimir Mitelberg
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Publication number: 20120157921Abstract: A therapeutic agent delivery system that includes a catheter having a proximal end and an opposite distal end. The catheter has a body with a lumen defined therein. The body of the catheter includes a non-bulbous region having a substantially uniform outer diameter and a bulbous region made from an elastically deformable material. While in a first state the bulbous region has a maximum outer diameter greater than the substantially uniform outer diameter of the non-bulbous region; and while in a second state the maximum outer diameter of the bulbous region is reduced relative to that while in the first state.Type: ApplicationFiled: February 25, 2012Publication date: June 21, 2012Applicant: Codman & Shurtleff, Inc.Inventors: John R. Hoofnagle, Greg Schorn, Terri Kapur, Daniel Keeley