Patents Assigned to Codon Pharmaceuticals, Inc.
  • Treatment of diseases mediated by the nitric oxide/cGMP/protein kinase G pathway
    Patent number: 5990177
    Abstract: Disclosed are methods and compositions for stimulating cellular nitric oxide (NO) synthesis, cyclic guanosine monophosphate levels (cGMP), and protein kinase G (PKG) activity for purposes of treating diseases mediated by deficiencies in the NO/cGMP/PKG signal transduction pathway, by administration of various compounds including alcohols, diols and/or triols and their analogues.
    Type: Grant
    Filed: September 18, 1997
    Date of Patent: November 23, 1999
    Assignee: Codon Pharmaceuticals, Inc.
    Inventor: David A. Brown
  • Methods and compositions for effecting homologous recombination
    Patent number: 5776744
    Abstract: Methods, compositions and kits for effecting homologous recombination are described. In one aspect, the method utilizes two introduced DNAs: (1) a mutagen-linked single-stranded oligonucleotide capable of specifically binding to double-stranded DNA to form a triple-stranded helix, and (2) a donor DNA fragment capable of undergoing homologous recombination with DNA targeted by the oligonucleotide.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 7, 1998
    Assignees: Yale University, Codon Pharmaceuticals, Inc.
    Inventors: Peter M. Glazer, L. Michael Lin, Jay George