Abstract: The present disclosure arises at least in part from the seminal recognition that a combination treatment regimen including one or more cycles and/or doses of a checkpoint inhibitor and a therapeutic, either sequentially, in either order, or substantially simultaneously, can be more effective in treating cancer in some subjects and/or can initiate, enable, increase, enhance or prolong the activity and/or number of immune cells, or a medically beneficial response by a tumor.
Type:
Application
Filed:
March 25, 2024
Publication date:
November 21, 2024
Applicants:
Cognate Bioservices, Inc., Northwest Biotherapeutics, Inc., The Regents of the University of California, RevImmune, Inc.
Inventors:
Marnix Leo Bosch, James Kelly Ganjei, Linda F. Powers, Linda M. Liau, Robert M. Prins
Abstract: A combination treatment regimen including one or more cycles and/or doses of a checkpoint inhibitor and a therapeutic, either sequentially, in either order, or substantially simultaneously, can be more effective in treating cancer in some subjects and/or can initiate, enable, increase, enhance or prolong the activity and/or number of immune cells, the efficacy of anti-tumor immune responses or a medically beneficial response by a tumor.
Type:
Application
Filed:
October 18, 2023
Publication date:
October 31, 2024
Applicants:
Cognate Bioservices, Inc., Northwest Biotherapeutics, Inc., The Regents of the University of California, RevImmune, Inc.
Inventors:
Marnix Leo Bosch, James Kelly Ganjei, Linda F. Powers, Linda M. Liau, Robert M. Prins
Abstract: The present invention relates to a method of isolating hematopoietic stem cells from adipose tissue. The method yields a notably high number of CD34+, ALDHbr and/or ABCG2-expressing cells, comprising hematopoietic stem cells, permitting the use of the cells with no or minimal expansion.
Abstract: The invention relates to the isolation and use of stem cells from amniote species (potentially any animal with an umbilical cord, including humans). More particularly the invention relates to obtaining stem cells that are at least multipotent and may be totipotent or nearly totipotent and are envisaged to have a variety of end uses. The cells of the present invention are immunosuppressive and may be used to inhibit the immune response in a subject.
Type:
Application
Filed:
March 21, 2008
Publication date:
December 4, 2008
Applicants:
Kansas State University Research Foundation, Cognate BioServices, Inc.
Inventors:
Mark Weiss, Rita Weiss, Cameron Anderson, Satish Medicetty, Irene Vanderwerff, Kevin R. McIntosh