Abstract: A system for providing and managing an automated agent. The automated agent may interact with a customer and utilize rules and instructions to determine a response to the customer and actions to perform. The customer interactions by the automated agent are driven by a set and/or subset of instructions that can be analyzed before each automated agent response or action. The subset of instructions, customer conversational input, and other content can be processed by a machine learning model, which may be implemented as a large language model (LLM).

Abstract: A system for generating instructions based on part from human training materials, wherein the generated instructions are used to train automated agents. The training materials may include training manuals, knowledge-base documents, articles, and other content. The training materials are processed and converted to a format that is digestible by a machine learning model. The processed training materials can be submitted as a prompt, along with role information and prompt instruction information. The prompt instructions provided with the role and training materials may direct the machine learning model to find relevant generated instructions from the provided training materials. The machine learning model processes the prompt and outputs extracted instructions from the content. The instruction document may be stored in a vector database for later use.

Abstract: The invention relates to crystalline forms of Alpha-1062 gluconate. In one aspect, the invention relates to a crystalline solid form of Alpha-1062 gluconate (Form C), wherein said crystalline form has prominent peaks at 3.90, 9.74, 10.35 and 21.43 degrees 2-theta (±0.2) in a powder X-ray diffraction pattern. The invention further relates to methods for treating a brain disease associated with cognitive impairment and/or with a cholinergic deficit in a subject, including administering the crystalline forms of Alpha-1062 gluconate to a subject in need thereof.

Abstract: A computer-implemented method and system includes accessing neurophysiological and neurovascular data recorded during sleep. A device mounted on a subject's head during sleep can gather neurovascular data by measuring transcranial impedance. The device can be in the form of a single band, multiple bands, or a headcap that are worn on the subject's head. Electrodes located along an inner surface of the wearable device contact the subject's head and measure transcranial impedance. Transcranial impedance measurements are gathered from multiple locations on the subject's head and over multiple frequencies to obtain a more complete assessment of glymphatic flow.

Abstract: A reading comprehension system may include an authoring tool to help generate adaptable dialogs and a reading tool to conduct adaptable dialog sessions with students. The authoring tool may receive and process stories to generate labeled stories and information models. The information models may provide the conceptual structures that an effective reader should build while reading and understanding a story. The system may use dialog models for general dialogs and information models for story specific dialogs to guide adaptable dialog sessions with students. During the adaptable dialog sessions, the system may constantly assess and guide the student's progress in the understanding the current story and in general reading comprehension development. Using the labeled stories and dialog sessions as training data, the system may learn how to dialog effectively with the students, to gather an evolving understanding of the student's abilities, and to acquire knowledge about the world or the story.

Abstract: A computer-implemented method and system includes a head-mounted wearable device with two current electrodes that provide input alternating currents over a range of frequencies to a subject during at least one intervention. The head-mounted wearable device includes at least two sense electrodes that collect voltage difference measurements in response to the input alternating currents. A measurement validation module applies a Hilbert transform or a Kramer-Kronig test to the voltage difference measurements to generate validated time-series impedance spectra. A cranial fluid dynamics module fits the validated time-series impedance spectra to an electrical circuit model to determine a glymphatic flow response to the at least one intervention.

Abstract: A research assistant system may include a research tool and components and a user interface to discover and evidence answers to complex research questions. The research tools may include components to iteratively perform steps in a research process, including searching, analyzing, connecting, aggregating, synthesizing, and chaining together evidence from a diverse set of knowledge sources. The system may receive an input query and perform a semantic search for key concepts in a text corpus. A semantic parser may interpret the search results. The system may aggregate and synthesize information from interpreted results. The system may rank and score the aggregated results data and present data on the user interface. The user interface may include prompts to iteratively guide user input to explore evidentiary chains and connect research concepts to produce research results annotated by evidence passages.

Abstract: A dynamic reasoning system may include a symbolic reasoning engine that iteratively calls a dynamic rule generator to answer an input query. The symbolic reasoning engine may determine a primary goal and/or secondary goals to generate proofs for the answer. The symbolic reasoning engine may call a rules component to provide rules to prove a current input goal. The rules component may use a static rule knowledge base and/or the dynamic rule generator to retrieve and rank rules relevant to the current input goal. The dynamic rule generator may generate new rules that lead to the current input goal. The dynamic rule generator may include a statistical model that generates unstructured or structured probabilistic rules based on context related to the input query. The symbolic reasoning engine may return a list of rules with confidence for explaining the answer to the input goal.

Abstract: A research assistant system may include a research tool and components and a user interface to discover and evidence answers to complex research questions. The research tools may include components to iteratively perform steps in a research process, including searching, analyzing, connecting, aggregating, synthesizing, and chaining together evidence from a diverse set of knowledge sources. The system may receive an input query and perform a semantic search for key concepts in a text corpus. A semantic parser may interpret the search results. The system may aggregate and synthesize information from interpreted results. The system may rank and score the aggregated results data and present data on the user interface. The user interface may include prompts to iteratively guide user input to explore evidentiary chains and connect research concepts to produce research results annotated by evidence passages.

Abstract: A research assistant system may include a research tool and components and a user interface to discover and evidence answers to complex research questions. The research tools may include components to iteratively perform steps in a research process, including searching, analyzing, connecting, aggregating, synthesizing, and chaining together evidence from a diverse set of knowledge sources. The system may receive an input query and perform a semantic search for key concepts in a text corpus. A semantic parser may interpret the search results. The system may aggregate and synthesize information from interpreted results. The system may rank and score the aggregated results data and present data on the user interface. The user interface may include prompts to iteratively guide user input to explore evidentiary chains and connect research concepts to produce research results annotated by evidence passages.

Abstract: The invention relates to crystalline forms of Alpha-1062 gluconate. In one aspect, the invention relates to a crystalline solid form of Alpha-1062 gluconate (Form A), wherein said crystalline form has prominent peaks at 3.61, 10.98, 14.41 and 18.44 degrees 2-theta (±0.2) in a powder X-ray diffraction pattern. The invention further relates to methods for manufacturing crystalline forms and compositions comprising said crystalline forms.

Abstract: A natural language interfacing system may use a knowledge acquisition tool to obtain structured representations from user input text. The system may initiate interaction with a request for input and a partial statement with blank text slots labeled by field types. The system may receive input text to fill in a slot of the partial statement and perform semantic parsing on the input text to identify a trigger concept. The system may generate a list of templates defining different semantic frames for the trigger concept. A generated template may include additional generated slots and/or suggested slot-fillers to guide user input. In response to a template selection, the partial statement includes the trigger concept annotated with a semantic frame. This process is repeated by iteratively updating the list of templates until the statement is completed. The statement is mapped to a structured representation including semantic frames.

Abstract: A selector configured to provide tactile feedback to the user. The selector can be incorporated into the fingertip of a glove, or many other suitable locations. Different size selectors can be provided for different application. Arrays of multiple selectors can also be provided. An embodiment of the inventive device includes a central plunger lying behind a conductive covering. A tactile surface is provided on the rear of the plunger. A compressive element is positioned to urge the plunger toward the conductive covering. When a user presses the selector against a touchscreen, the plunger is pushed away from the touchscreen and the tactile surface on the plunger presses against the user. The pressing of the tactile surface provides feedback to the user.

Abstract: A research assistant system may include a research tool and components and a user interface to discover and evidence answers to complex research questions. The research tools may include components to iteratively perform steps in a research process, including searching, analyzing, connecting, aggregating, synthesizing, and chaining together evidence from a diverse set of knowledge sources. The system may receive an input query and perform a semantic search for key concepts in a text corpus. A semantic parser may interpret the search results. The system may aggregate and synthesize information from interpreted results. The system may rank and score the aggregated results data and present data on the user interface. The user interface may include prompts to iteratively guide user input to explore evidentiary chains and connect research concepts to produce research results annotated by evidence passages.

Abstract: An individualized machine learning model embedded on a mobile health application, coupled to autonomous workflow agents systems to operate as a small artificial intelligence program. The machine learning algorithm learns from small datasets—making it possible to compute real-time data even on a low-grade smartphone device. It predicts early worsening outcomes by extracting patterns (features) that correlate with the individual baseline changes in heart failure status. The workflow agents support dynamic machine learning model deployment to different devices and configurations for real-time prediction and intervention. The different device configurations include patients who own only a smartphone device, patients who own a smartphone and wearable/biosensors, and patients who own a smartphone and who have an implanted cardiac device.

Abstract: A graphical user interface allowing one or more users to rapidly perceive and respond to varying operational states. Glyphs depicting differing levels of detail are provided for a top-level manager versus a lower-level operator. As applied to the vehicle paradigm, each individual glyph presents information as to the vehicle's current assigned task, mode, state, status, and its progress in completing that task. Each display shows multiple glyphs representing multiple vehicles. A vehicle in need of attention rises in the depiction whereas a vehicle not needing attention remains in a low position.

Abstract: Methods and systems for remote support of autonomous operation of vehicles have been disclosed. State indicators are generated by a first state display based on state data from a portion of vehicles assigned to a respective first level control station. A second state display is generated for a second control station and displays state indicators for the state data of the vehicles. A remote support interface including the first state display and image data received from a first vehicle of the vehicles is generated. Instruction data to the first vehicle is transmitted using the remote support interface and based on an indication that the first vehicle needs remote support, the instruction data modifying the autonomous operation of the first vehicle. A workload between the first level control stations is allocated by assigning the vehicles using the state indicators of the second state display.

Abstract: A planar coil linear actuator/transducer. A stack of individually driven planar coils are used. A common core passes through the center of the stack of coils. A mobile magnet resides in the core. The coils are selectively energized in order to drive the magnet as desired. It is possible to control both frequency and amplitude by controlling the motion of the magnet. In a preferred embodiment, each planar coil is created as a copper (or other conductive material) trace on a multi-layer printed circuit board.

Abstract: A system and method using a microphone to collect sound data produced by a potential patient's respiration and speech. The system preferably uses a microphone on a portable electronic device—such as a smart phone. The analysis of the collected data is preferably performed locally—such as by a software application running on the smartphone. The software is used to analyze the data and therefore determine and track useful parameters such as respiration rate and respiratory tidal volume. The software also analyzes phonation patterns. Using the parameters, the inventive system can detect the onset of respiratory distress.

Abstract: A cable-based exercise system. A chassis is provided to house the actuators. A force plate sits on top of this chassis. A bar configured for gripping by a user is provided. The bar has a first end and a second end. Two or more cables are connected to each end of the bar. Each cable connects an end of the bar to a drive motor. Each drive motor can be independently controlled. A central processor is preferably provided to receive sensory inputs and control the drive motors.