Patents Assigned to Cognos Therapeutics Inc.
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Patent number: 12076527Abstract: The illustrated embodiments of the invention include an MRI compatible apparatus having: a refillable drug reservoir; a hermetically sealed, implantable chamber; a pump disposed in and hermetically sealed within the hermetically sealed, implantable chamber and fluidically communicated to the drug reservoir; and control electronics disposed in and hermetically sealed within the hermetically sealed, implantable chamber and electrically communicated to the pump. The refillable drug reservoir, hermetically sealed, implantable chamber, pump and control electronics are MRI compatible.Type: GrantFiled: April 29, 2019Date of Patent: September 3, 2024Assignee: Cognos Therapeutics Inc.Inventors: Yehoshua Shachar, Winston Wu
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Patent number: 11890111Abstract: A skull-mounted drug and pressure sensor (SOS), a smart pump (ISP) electrically coupled to the SOS and a drug delivery and communications catheter communicating the SOS with the ISP are combined for a first embodiment. A skull-mounted (SOS), a metronomic biofeedback pump (MBP) electrically coupled to the SOS and a drug delivery and communications catheter having a sending and receiving optical fiber communicating the SOS with the MBP are combined for a second embodiment. A third embodiment combines a (SOS), an implantable power and communication unit (PCU) electrically coupled to the SOS, and a drug delivery and communications catheter for communicating the SOS with the PCU and for communicating the exterior source of the drug to the SOS. A fourth embodiment combines a ventricular catheter with a CSF accessible chamber and drug delivery port; and an implantable stand-alone skull-mounted drug and pressure sensor (SPS).Type: GrantFiled: March 6, 2020Date of Patent: February 6, 2024Assignee: Cognos Therapeutics Inc.Inventors: Yehoshua Shachar, Thomas Chen, Thomas J. Lobl, Jeffrey A. Brydle, Juan R. Gonzalez, Virote Indravudh, Christian Merot, Allan R. Schwartz, Chad Srisathapat
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Patent number: 11890112Abstract: A skull-mounted drug and pressure sensor (SOS), a smart pump (ISP) electrically coupled to the SOS and a drug delivery and communications catheter communicating the SOS with the ISP are combined for a first embodiment. A skull-mounted (SOS), a metronomic biofeedback pump (MBP) electrically coupled to the SOS and a drug delivery and communications catheter having a sending and receiving optical fiber communicating the SOS with the MBP are combined for a second embodiment. A third embodiment combines a (SOS), an implantable power and communication unit (PCU) electrically coupled to the SOS, and a drug delivery and communications catheter for communicating the SOS with the PCU and for communicating the exterior source of the drug to the SOS. A fourth embodiment combines a ventricular catheter with a CSF accessible chamber and drug delivery port; and an implantable stand-alone skull-mounted drug and pressure sensor (SPS).Type: GrantFiled: March 6, 2020Date of Patent: February 6, 2024Assignee: Cognos Therapeutics Inc.Inventors: Yehoshua Shachar, Thomas Chen, Thomas J. Lobl, Jeffrey A. Brydle, Juan R. Gonzalez, Virote Indravudh, Christian Merot, Allan R. Schwartz, Chad Srisathapat
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Patent number: 11883203Abstract: A skull-mounted drug and pressure sensor (SOS), a smart pump (ISP) electrically coupled to the SOS and a drug delivery and communications catheter communicating the SOS with the ISP are combined for a first embodiment. A skull-mounted (SOS), a metronomic biofeedback pump (MBP) electrically coupled to the SOS and a drug delivery and communications catheter having a sending and receiving optical fiber communicating the SOS with the MBP are combined for a second embodiment. A third embodiment combines a (SOS), an implantable power and communication unit (PCU) electrically coupled to the SOS, and a drug delivery and communications catheter for communicating the SOS with the PCU and for communicating the exterior source of the drug to the SOS. A fourth embodiment combines a ventricular catheter with a CSF accessible chamber and drug delivery port; and an implantable stand-alone skull-mounted drug and pressure sensor (SPS).Type: GrantFiled: February 28, 2020Date of Patent: January 30, 2024Assignee: Cognos Therapeutics Inc.Inventors: Yehoshua Shachar, Thomas Chen, Thomas J. Lobl, Jeffrey A. Brydle, Juan R. Gonzalez, Virote Indravudh, Christian Merot, Allan R. Schwartz, Chad Srisathapat
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Publication number: 20230191095Abstract: The invention includes a ventriculo-peritoneal shunt and a method of operating it. The shunt includes: a ventricular catheter for transferring CSF from the ventricle of a brain of a patient; a pressure sensor communicated to the ventricular catheter to measure the pressure of the CSF as delivered to the pressure sensor; a temperature sensor communicated to the ventricular catheter to measure the temperature of the CSF as delivered to the temperature sensor; a wireless data transmitter to transmit the measured pressure and temperature to an attending physician; a nonprogrammable reporting valve or programmable valve communicated to the pressure sensor and temperature sensor to regulate flow of the CSF; and peritoneal tubing communicated to the programmable valve for delivering CSF to the peritoneal cavity.Type: ApplicationFiled: December 22, 2021Publication date: June 22, 2023Applicant: Cognos Therapeutics Inc.Inventors: Thomas C. Chen, Josh Shachar, Thomas Lobl, Winston Wu
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Patent number: 11529443Abstract: An apparatus for performing cerebral micro-dialysis to treat neurological disease of a patient's brain includes a catheter for implantation in or near the patient's brain, an implantable pump communicated with the catheter to transport cerebrospinal fluid (CSF) from the patient, which CSF contains diseased cells or biomolecules associated with the neurological disease, and an implantable separation device communicated with the pump wherein the diseased cells or biomolecules are removed, where the separation apparatus includes a dialysis membrane impregnated with an antibody, a reversible electrostatic filter, and/or a magnetic field effect fractionation chamber wherein a magnetically-tagged antibody scavenges and aids in the removal of circulating diseased cells or biomolecules from the CSF.Type: GrantFiled: December 27, 2016Date of Patent: December 20, 2022Assignee: Cognos Therapeutics Inc.Inventors: Roger Kornberg, Yehoshua Shachar, Thomas Chen
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Patent number: 10786155Abstract: A skull-mounted drug and pressure sensor (SOS), a smart pump (ISP) electrically coupled to the SOS and a drug delivery and communications catheter communicating the SOS with the ISP are combined for a first embodiment. A skull-mounted (SOS), a metronomic biofeedback pump (MBP) electrically coupled to the SOS and a drug delivery and communications catheter having a sending and receiving optical fiber communicating the SOS with the MBP are combined for a second embodiment. A third embodiment combines a (SOS), an implantable power and communication unit (PCU) electrically coupled to the SOS, and a drug delivery and communications catheter for communicating the SOS with the PCU and for communicating the exterior source of the drug to the SOS. A fourth embodiment combines a ventricular catheter with a CSF accessible chamber and drug delivery port; and an implantable stand-alone skull-mounted drug and pressure sensor (SPS).Type: GrantFiled: May 12, 2017Date of Patent: September 29, 2020Assignee: Cognos Therapeutics Inc.Inventors: Yehoshua Shachar, Thomas Chen, Thomas J. Lobl, Jeffrey A. Brydle, Juan R. Gonzalez, Virote Indravudh, Christian Merot, Allan R. Schwartz, Chad Srisathapat
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Publication number: 20200214567Abstract: A skull-mounted drug and pressure sensor (SOS), a smart pump (ISP) electrically coupled to the SOS and a drug delivery and communications catheter communicating the SOS with the ISP are combined for a first embodiment. A skull-mounted (SOS), a metronomic biofeedback pump (MBP) electrically coupled to the SOS and a drug delivery and communications catheter having a sending and receiving optical fiber communicating the SOS with the MBP are combined for a second embodiment. A third embodiment combines a (SOS), an implantable power and communication unit (PCU) electrically coupled to the SOS, and a drug delivery and communications catheter for communicating the SOS with the PCU and for communicating the exterior source of the drug to the SOS. A fourth embodiment combines a ventricular catheter with a CSF accessible chamber and drug delivery port; and an implantable stand-alone skull-mounted drug and pressure sensor (SPS).Type: ApplicationFiled: March 6, 2020Publication date: July 9, 2020Applicant: Cognos Therapeutics Inc.Inventors: Yehoshua Shachar, Thomas Chen, Thomas J. Lobl, Jeffrey A. Brydle, Juan R. Gonzalez, Virote Indravudh, Christian Merot, Allan R. Schwartz, Chad Srisathapat
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Publication number: 20200205663Abstract: A skull-mounted drug and pressure sensor (SOS), a smart pump (ISP) electrically coupled to the SOS and a drug delivery and communications catheter communicating the SOS with the ISP are combined for a first embodiment. A skull-mounted (SOS), a metronomic biofeedback pump (MBP) electrically coupled to the SOS and a drug delivery and communications catheter having a sending and receiving optical fiber communicating the SOS with the MBP are combined for a second embodiment. A third embodiment combines a (SOS), an implantable power and communication unit (PCU) electrically coupled to the SOS, and a drug delivery and communications catheter for communicating the SOS with the PCU and for communicating the exterior source of the drug to the SOS. A fourth embodiment combines a ventricular catheter with a CSF accessible chamber and drug delivery port; and an implantable stand-alone skull-mounted drug and pressure sensor (SPS).Type: ApplicationFiled: March 6, 2020Publication date: July 2, 2020Applicant: Cognos Therapeutics Inc.Inventors: Yehoshua Shachar, Thomas Chen, Thomas J. Lobl, Jeffrey A. Brydle, Juan R. Gonzalez, Virote Indravudh, Christian Merot, Allan R. Schwartz, Chad Srisathapat
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Publication number: 20200196868Abstract: A skull-mounted drug and pressure sensor (SOS), a smart pump (ISP) electrically coupled to the SOS and a drug delivery and communications catheter communicating the SOS with the ISP are combined for a first embodiment. A skull-mounted (SOS), a metronomic biofeedback pump (MBP) electrically coupled to the SOS and a drug delivery and communications catheter having a sending and receiving optical fiber communicating the SOS with the MBP are combined for a second embodiment. A third embodiment combines a (SOS), an implantable power and communication unit (PCU) electrically coupled to the SOS, and a drug delivery and communications catheter for communicating the SOS with the PCU and for communicating the exterior source of the drug to the SOS. A fourth embodiment combines a ventricular catheter with a CSF accessible chamber and drug delivery port; and an implantable stand-alone skull-mounted drug and pressure sensor (SPS).Type: ApplicationFiled: February 28, 2020Publication date: June 25, 2020Applicant: Cognos Therapeutics Inc.Inventors: Yehoshua Shachar, Thomas Chen, Thomas J. Lobl, Jeffrey A. Brydle, Juan R. Gonzalez, Virote Indravudh, Christian Merot, Allan R. Schwartz, Chad Srisathapat
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Publication number: 20170325685Abstract: A skull-mounted drug and pressure sensor (SOS), a smart pump (ISP) electrically coupled to the SOS and a drug delivery and communications catheter communicating the SOS with the ISP are combined for a first embodiment. A skull-mounted (SOS), a metronomic biofeedback pump (MBP) electrically coupled to the SOS and a drug delivery and communications catheter having a sending and receiving optical fiber communicating the SOS with the MBP are combined for a second embodiment. A third embodiment combines a (SOS), an implantable power and communication unit (PCU) electrically coupled to the SOS, and a drug delivery and communications catheter for communicating the SOS with the PCU and for communicating the exterior source of the drug to the SOS. A fourth embodiment combines a ventricular catheter with a CSF accessible chamber and drug delivery port; and an implantable stand-alone skull-mounted drug and pressure sensor (SPS).Type: ApplicationFiled: May 12, 2017Publication date: November 16, 2017Applicant: Cognos Therapeutics Inc.Inventors: Yehoshua Shachar, Thomas Chen, Thomas J. Lobl, Jeffrey A. Brydle, Juan R. Gonzalez, Virote Indravudh, Christian Merot, Allan R. Schwartz, Chad Srisathapat