Patents Assigned to Cohera Medical, Inc.
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Patent number: 10016454Abstract: A tissue sealant that includes the reaction product of (a) a polyol; (b) a polyisocyanate; and (c) an alkoxy silane having the formula: (R1R2R3)—Si—CH2—Z where (i) Z is an —OH, —SH, —NCO, or —NHR4 group, where R4 is hydrogen, an alkyl group, or an aryl group; and (ii) each R1, R2, and R3, independently, is H, an alkoxy group, an alkyl group, a heteroalkyl group other than an alkoxy group, an aryl group, or a heteroaryl group, with the proviso that at least two of R1, R2, and R3 are alkoxy groups, the relative amounts of the polyol, polyisocyanate, and alkoxy silane being selected such that the reaction product comprises free isocyanate groups. The tissue sealant is moisture-curable and biodegradable in a physiological environment.Type: GrantFiled: December 4, 2012Date of Patent: July 10, 2018Assignee: Cohera Medical, Inc.Inventors: Dottie Clower, Despina Dobbins, Stephanie Kladakis
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Patent number: 9743917Abstract: Devices for and methods that can be used in endoscopic surgery, and more particularly, devices and methods that can be used for endoscopically applying surgical sealants and other fluids to internal organs and tissues.Type: GrantFiled: December 19, 2014Date of Patent: August 29, 2017Assignee: Cohera Medical, Inc.Inventors: Patrick Daly, Despina Dobbins, Scott Scheeser
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Patent number: 9295750Abstract: A method of making a composition comprising reacting (a) an isocyanate group-containing component having an average functionality of at least 2; and (b) an active hydrogen group-containing component having an average functionality of at least 2 to form a composition that is biodegradable, a solid at 22° C. and below, and has pressure sensitive adhesive properties at a temperature of 37° C. and relative humidity of 100%. A method of using the composition therefore to adhere polymer meshes or films to biological tissue is also disclosed.Type: GrantFiled: November 24, 2014Date of Patent: March 29, 2016Assignee: Cohera Medical, Inc.Inventors: Eric J. Beckman, Jessica L. Meyers
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Patent number: 8950629Abstract: This document relates to delivery devices for dispensing fluid materials, including high viscosity fluids such as high viscosity surgical adhesives. For example, methods and materials for an integrated system of containing and permitting point of use delivery of a high viscosity adhesive fluid onto a planar surface of tissue during a surgical procedure are provided.Type: GrantFiled: May 19, 2010Date of Patent: February 10, 2015Assignee: Cohera Medical, Inc.Inventors: Jeffrey S. Kapec, Kazuna Tanaka, Yukiko Naoi, Kenneth Allen Focht, Gerhard Liepold
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Patent number: 8895052Abstract: A composition comprising the reaction product of (a) an isocyanate group-containing component having an average functionality of at least 2; and (b) an active hydrogen group-containing component having an average functionality of at least 2. The composition is biodegradable, a solid at 22° C. and below, and has pressure sensitive adhesive properties at a temperature of 37° C. and relative humidity of 100%. The composition may be used to adhere polymer meshes or films to biological tissue.Type: GrantFiled: November 15, 2011Date of Patent: November 25, 2014Assignee: Cohera Medical, Inc.Inventors: Eric J. Beckman, Jessica L. Meyers
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Publication number: 20140154204Abstract: A tissue sealant that includes the reaction product of (a) a polyol; (b) a polyisocyanate; and (c) an alkoxy silane having the formula: (R1R2R3)—Si—CH2—Z where (i) Z is an —OH, —SH, —NCO, or —NHR4 group, where R4 is hydrogen, an alkyl group, or an aryl group; and (ii) each R1, R2, and R3, independently, is H, an alkoxy group, an alkyl group, a heteroalkyl group other than an alkoxy group, an aryl group, or a heteroaryl group, with the proviso that at least two of R1, R2, and R3 are alkoxy groups, the relative amounts of the polyol, polyisocyanate, and alkoxy silane being selected such that the reaction product comprises free isocyanate groups. The tissue sealant is moisture-curable and biodegradable in a physiological environment.Type: ApplicationFiled: December 4, 2012Publication date: June 5, 2014Applicant: COHERA MEDICAL, INC.Inventors: Dottie Clower, Despina Dobbins, Stephanie Kladakis
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Patent number: 8652293Abstract: A moisture-curable and biodegradable adhesive that includes the reaction product of: (a) an isocyanate component having an average functionality of at least 2; (b) an active hydrogen component having an average functionality greater than 2.1; and (c) an ionic salt component having an average hydroxyl or amino functionality, or combination thereof, of at least 1.Type: GrantFiled: April 5, 2012Date of Patent: February 18, 2014Assignee: Cohera Medical, Inc.Inventors: Jason Smith, Eric Beckman
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Patent number: 8287566Abstract: Some embodiments of a spray device can be configured to maintain a viscous fluid in isolation from a propellant fluid until after the viscous fluid exits from a nozzle of the spray device. For example, the viscous fluid may include an adhesive such as surgical adhesive. When the spray device is actuated, the surgical adhesive can exit the nozzle so that the propellant fluid acts upon the surgical adhesive to break it into droplets for application on a targeted site.Type: GrantFiled: October 26, 2007Date of Patent: October 16, 2012Assignee: Cohera Medical, Inc.Inventors: Phillip M. Leopold, Allan Roberts
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Patent number: 8182647Abstract: A moisture-curable and biodegradable adhesive that includes the reaction product of: (a) an isocyanate component having an average functionality of at least 2; (b) an active hydrogen component having an average functionality greater than 2.1; and (c) an ionic salt component having an average hydroxyl or amino functionality, or combination thereof, of at least 1.Type: GrantFiled: May 20, 2008Date of Patent: May 22, 2012Assignee: Cohera Medical, Inc.Inventors: Jason Smith, Eric Beckman
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Publication number: 20120121686Abstract: A composition comprising the reaction product of (a) an isocyanate group-containing component having an average functionality of at least 2; and (b) an active hydrogen group-containing component having an average functionality of at least 2. The composition is biodegradable, a solid at 22° C. and below, and has pressure sensitive adhesive properties at a temperature of 37° C. and relative humidity of 100%. The composition may be used to adhere polymer meshes or films to biological tissue.Type: ApplicationFiled: November 15, 2011Publication date: May 17, 2012Applicant: COHERA MEDICAL, INC.Inventors: Eric J. Beckman, Jessica L. Meyers
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Publication number: 20090112255Abstract: Some embodiments of a spray device can be configured to maintain a viscous fluid in isolation from a propellant fluid until after the viscous fluid exits from a nozzle of the spray device. For example, the viscous fluid may comprise an adhesive such a surgical adhesive. When the spray device is actuated, the surgical adhesive can exit the nozzle whereat the propellant fluid acts upon the surgical adhesive to break it into droplets for application on a targeted site.Type: ApplicationFiled: October 26, 2007Publication date: April 30, 2009Applicant: COHERA MEDICAL, INC.Inventors: Phillip M. Leopold, Allan Roberts