Patents Assigned to Colby Pharmaceutical Company
  • Androgen induced oxidative stress inhibitors
    Patent number: 9023837
    Abstract: Described herein are pharmaceutical compositions and medicaments, and methods of using such pharmaceutical compositions and medicaments in the treatment of cancer.
    Type: Grant
    Filed: April 15, 2011
    Date of Patent: May 5, 2015
    Assignee: Colby Pharmaceutical Company
    Inventors: Hirak S. Basu, David A. Zarling, George Wilding, Farideh Mehraein-Ghomi, Dawn R. Church
  • ANDROGEN INDUCED OXIDATIVE STRESS INHIBITORS
    Publication number: 20130210772
    Abstract: Described herein are pharmaceutical compositions and medicaments, and methods of using such pharmaceutical compositions and medicaments in the treatment of cancer.
    Type: Application
    Filed: April 15, 2011
    Publication date: August 15, 2013
    Applicant: COLBY PHARMACEUTICAL COMPANY
    Inventors: Hirak S. Basu, David A. Zarling, George Wilding, Farideh Mehraein-Ghomi, Dawn R. Church
  • Mitochondria targeted cationic anti-oxidant compounds for prevention, therapy or treatment of hyper-proliferative disease, neoplasias and cancers
    Patent number: 8466130
    Abstract: The inventions disclosed include methods of treating cancers and related neoplasias, especially prostate cancer, with pharmaceutically acceptable salts comprising lipophilic cation moieties linked to nitroxide or linked to hydroxylamine anti-oxidant groups.
    Type: Grant
    Filed: September 4, 2009
    Date of Patent: June 18, 2013
    Assignees: Colby Pharmaceutical Company, Medical College of Wisconsin, Inc.
    Inventors: David A. Zarling, Hirak S. Basu, Balaraman Kalyanaraman, Joy Joseph
  • Amelioration of the development of cataracts and other ophthalmic diseases
    Patent number: 8383648
    Abstract: Ophthalmically acceptable compositions used in arresting the development of cataracts or macular degeneration comprising a pharmaceutically acceptable carrier or diluent and a compound having the formula: where R1 and R2 are, independently, H or C1 to C3 alkyl; R3 and R4 are, independently C1 to C3 alkyl; and where R1 and R2, taken together, or R3 and R4, taken together, or both may be cycloalkyl; R5 is H, OH, or C1 to C6 alkyl; R6 is or C1 to C6 alkyl, alkenyl, alkynyl, or substituted alkyl or alkenyl; R7 is C1 to C6 alkyl, alkenyl, alkynyl, or substituted alkyl or alkenyl or where R6 and R7, or R5, R6 and R7, taken together, form a carbocycle or heterocycle having from 3 to 7 atoms in the ring.
    Type: Grant
    Filed: June 18, 2008
    Date of Patent: February 26, 2013
    Assignee: Colby Pharmaceutical Company
    Inventors: William L. Matier, Ghanshyam Patil
  • Methods and Kits for Determining Oxygen Free Radical (OFR) Levels in Animal and Human Tissues as a Prognostic Marker for Cancer and Other Pathophysiologies
    Publication number: 20110091931
    Abstract: Described herein are methods and techniques for the determination of reactive oxygen species in resected animal and human tissues. Also described herein are methods for determining the efficacy of anti-oxidant, oxidative stress modulatory, or anti-inflammatory drug chemoprevention or chemotherapy for the prevention and/or therapy of chronically inflamed and/or progressive cancers and pathophysiologies.
    Type: Application
    Filed: April 23, 2010
    Publication date: April 21, 2011
    Applicant: COLBY PHARMACEUTICAL COMPANY
    Inventors: Hirak S. Basu, David Zarling
  • MITOCHONDRIA TARGETED CATIONIC ANTI-OXIDANT COMPOUNDS FOR PREVENTION, THERAPY OR TREATMENT OF HYPER-PROLIFERATIVE DISEASE, NEOPLASIAS AND CANCERS
    Publication number: 20110059922
    Abstract: The inventions disclosed include methods of treating cancers and related neoplasias, especially prostate cancer, with pharmaceutically acceptable salts comprising lipophilic cation moieties linked to nitroxide or linked to hydroxylamine anti-oxidant groups.
    Type: Application
    Filed: September 4, 2009
    Publication date: March 10, 2011
    Applicants: COLBY PHARMACEUTICAL COMPANY, MEDICAL COLLEGE OF WISCONSIN, INC.
    Inventors: David A. Zarling, Hirak S. Basu, Balaraman Kalyanaraman, Joy Joseph
  • PHARMACEUTICALLY ACTIVE COMPOSITIONS COMPRISING OXIDATIVE STRESS MODULATORS (OSM), NEW CHEMICAL ENTITIES, COMPOSITIONS AND USES
    Publication number: 20100297262
    Abstract: Described herein are pharmaceutical compositions and medicaments, and methods of using such pharmaceutical compositions and medicaments in the treatment of inflammation and cancer.
    Type: Application
    Filed: April 16, 2010
    Publication date: November 25, 2010
    Applicant: COLBY PHARMACEUTICAL COMPANY
    Inventors: Hirak S. Basu, David A. Zarling