Patents Assigned to Cold Spring Harbir Laboratory
  • Structurally designed shRNAs
    Patent number: 8273871
    Abstract: Provided is an improved design of shRNA based on structural mimics of miR-451 precursors. These miR-451 shRNA mimics are channeled through a novel small RNA biogenesis pathway, require AGO2 catalysis and are processed by Drosha but are independent of DICER processing. This miRNA pathway feeds active elements only into Ago2 because of its unique catalytic activity. These data demonstrate that this newly identified small RNA biogenesis pathway can be exploited in vivo to produce active molecules.
    Type: Grant
    Filed: October 4, 2011
    Date of Patent: September 25, 2012
    Assignee: Cold Spring Harbir Laboratory
    Inventors: Gregory J. Hannon, Sihem Cheloufi