Abstract: Some fluid coupling devices described herein are configured for use in fluid systems for purposes of providing a repeatable, aseptic fluid coupling system. Such repeatable, aseptic fluid coupling systems are configured to facilitate multiple connection and disconnection cycles while repeatably establishing a sterile fluid pathway through the coupling system. The repeatable, aseptic fluid coupling systems can repeatably establish a sterile fluid pathway through the coupling system even though the coupling system may be used in a non-sterile environment.

Abstract: Fluid couplings described herein are designed to prevent spillage of fluid when connecting and disconnecting the couplings. In some embodiments, the fluid couplings described herein include internal valve components. In some example embodiments, the internal valve components include two springs that are arranged to exert their spring forces in parallel with each other to bias a valve component to a normally closed position. Some embodiments include a single spring. In particular embodiments, components of the fluid couplings and fluid flow paths of the fluid couplings have oblong transverse cross-sectional shapes.

Abstract: Fluid handling couplings can be made to connect and disconnect other members of a fluid handling system. For example, this document describes fluid couplings that are convenient to couple/decouple and that provide strong resistance to inadvertent disconnection when subjected to rotation while pressurized. In some embodiments, the resistance to inadvertent disconnection is facilitated by a latch mechanism of the female coupling that includes a protrusion that becomes seated in a groove of a mated male coupling.

Abstract: Some fluid coupling devices described herein are configured for use in fluid systems for purposes of providing a single-use, disconnection functionality that can substantially limit fluid spillage when being disconnected. In some embodiments, the coupling portions cannot be functionally reconnected to each other after being disconnected from each other.

Abstract: A female coupling device includes: a main body, and a clip member coupled to the main body, the clip member having a plurality of arms extending perpendicularly therefrom, with the plurality of arms forming at least one pair of arms, with the pair of arms including a first distance therebetween and a second distance therebetween, with the first distance being sized to engage a clip groove of a mating male coupling device, and with the second distance being sized to disengage the mating male coupling device. In a locked position, the pair of arms is positioned so that the first distance is adjacent to the mating male coupling device. In an unlocked position, the pair of arms is positioned so that the second distance is adjacent to the mating male coupling device.

Abstract: This document describes aseptic fluid coupling devices for fluid systems and methods of manufacturing such aseptic fluid coupling devices. For example, this document describes aseptic fluid coupling devices that include removable membrane strips that protect the interior of the aseptic fluid coupling devices from contamination prior to use. Methods for attaching removable membranes to the aseptic fluid coupling devices are also described.

Abstract: An aseptic coupling arrangement can include a first coupling device and a second aseptic coupling device. In one embodiment, the first and second coupling devices are substantially similar, each having a main body defining a front face and a fluid passageway therethrough. A first connecting feature disposed on the main body of each coupling device may be provided for aligning and coupling the aseptic devices together. Each coupling device may also include a sealing member received in the main body and a membrane removably coupled to the main body front face to cover the sealing member. The first aseptic coupling device may also include a rotatable protective cover that is removably attached to the main body and connected to the membrane. In one embodiment, the removal of the protective covers away from two coupled main bodies, in a direction parallel to the front faces, causes removal of the membranes.

Abstract: This document describes devices and methods for reducing liquid spillage, such as fluid coupling devices that include one or more apertures that reduce spillage when the fluid coupling devices are disconnected. In some embodiments, the one or more apertures are designed with features to increase a level of acceleration that liquid within an internal volume of the fluid coupling devices would need to be exposed to in order to spill from the internal volume via the one or more apertures.

Abstract: A coupling system includes a female coupling device, the female coupling device including a first main body with a first front face, the first front face defining a first opening leading into a first fluid passageway; a stem having a stem head positioned within a sleeve; a first spring positioned about the stem that biases the sleeve into a closed position; a first seal that seals between the main body and the sleeve; a second seal that seals between the sleeve and the stem head; and a third seal that is positioned at the opening of the main body. The coupling system includes a male coupling device, the male coupling device including a second main body with a second front face, the second front face defining a second opening leading into a second fluid passageway; a valve member and a second spring positioned within the second fluid passageway; and a major seal that seals between the second main body and the valve member.

Abstract: A coupling system includes a female coupling device, the female coupling device including a first main body with a first front face, the first front face defining a first opening leading into a first fluid passageway; a stem having a stem head positioned within a sleeve; a first spring positioned about the stem that biases the sleeve into a closed position; a first seal that seals between the main body and the sleeve; a second seal that seals between the sleeve and the stem head; and a third seal that is positioned at the opening of the main body.

Abstract: A coupling system includes a female coupling device, the female coupling device including a first main body with a first front face, the first front face defining a first opening leading into a first fluid passageway; a stem having a stem head positioned within a sleeve; a first spring positioned about the stem that biases the sleeve into a closed position; a first seal that seals between the main body and the sleeve; a second seal that seals between the sleeve and the stem head; and a third seal that is positioned at the opening of the main body. The coupling system includes a male coupling device, the male coupling device including a second main body with a second front face, the second front face defining a second opening leading into a second fluid passageway; a valve member and a second spring positioned within the second fluid passageway; and a major seal that seals between the second main body and the valve member.

Abstract: Fluid handling couplings can be made to connect and disconnect other members of a fluid handling system. For example, this document describes fluid couplings that are convenient to couple/decouple and that provide strong resistance to inadvertent disconnection when subjected to rotation while pressurized. In some embodiments, the resistance to inadvertent disconnection is facilitated by a latch mechanism of the female coupling that includes a protrusion that becomes seated in a groove of a mated male coupling.

Abstract: Formation of a sterile connection includes inserting a first aseptic coupling device into a second aseptic coupling device, removing a first membrane from the first aseptic coupling device and a second membrane from the second aseptic coupling device, and rotating a locking clip on the first aseptic coupling device to compress a first seal member of the first aseptic coupling device with a second seal member of the second aseptic coupling device to form a sterile fluid passageway.

Abstract: A female coupling device includes: a main body, and a clip member coupled to the main body, the clip member having a plurality of arms extending perpendicularly therefrom, with the plurality of arms forming at least one pair of arms, with the pair of arms including a first distance therebetween and a second distance therebetween, with the first distance being sized to engage a clip groove of a mating male coupling device, and with the second distance being sized to disengage the mating male coupling device. In a locked position, the pair of arms is positioned so that the first distance is adjacent to the mating male coupling device. In an unlocked position, the pair of arms is positioned so that the second distance is adjacent to the mating male coupling device.

Abstract: Formation of a sterile connection includes inserting a first aseptic coupling device into a second aseptic coupling device while a locking ring of the first aseptic device is in an indexed initial position, rotating the locking ring to a secured position in which a compressive force is created and in which a first membrane from the first aseptic coupling device and a second membrane from the second aseptic coupling device can removed thereby resulting in a first a first sealing member of the first aseptic coupling device sealing with a second sealing member of the second aseptic coupling device to form a sterile fluid passageway.