Abstract: An apparatus for subjecting articles of manufacture to a cryogenic thermal cycling process includes a bottom portion and a lid. The bottom portion comprises an outer and inner tank separated by a plurality of insulation layers. The inner tank defines an inner cavity wherein the articles are subjected to the cryogenic process. A thermal break is provided between the lid and bottom portion so that the temperature of the inner cavity does not conduct to the outer tank of the apparatus bottom portion. The process conducted in the apparatus is controlled by a pre-programmed profile inputted by a key controller or PC. Liquid nitrogen is the preferred cryogenic material to be employed. The novel process subjects the article to extreme negative temperatures thereafter cycling the article between a set of negative temperatures for a number of cycles. The process is completed by heating the article to an extreme positive temperature and then allowed to cool to ambient room temperature.