Abstract: The subject matter of the present invention is a microfluidic process for treating and analysing a solution containing a biological material, comprising a step of introducing the solution into microchannels of a microfluidic circuit (1), a step of forming drops of this solution, under the effect of modifications of the surface tension of the solution, a step of moving the drops to one or more drop storage zones(s) (130), under the effect of modifications of the surface tension of the drops, a step of treating the drops and a step of analysing the drops.
Type:
Grant
Filed:
July 19, 2021
Date of Patent:
August 27, 2024
Assignees:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ÉCOLE POLYTECHNIQUE
Inventors:
Charles Baroud, Rémi Dangla, Paul Abbyad, Silvan Turkcan
Abstract: A process for the nitrogen doping of a material includes a set of carbon atoms in the sp2 hybridization state. The process further includes the material not being oxidized beforehand, then placing the material in contact with dinitrogen. Irradiating the material and the dinitrogen placed in contact with a beam of electrons or of light ions whose energy is greater than or equal to 0.1 MeV, to obtain a material wherein some of the carbon atoms in the sp2 hybridization state is nitrogen-doped.
Type:
Grant
Filed:
September 15, 2017
Date of Patent:
March 1, 2022
Assignees:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ÉCOLE POLYTECHNIQUE, COMMISSARIAT À L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES
Inventors:
Catherine Corbel, Irina Shchedrina, Jean-Philippe Renault
Abstract: There is described a method for delivering exogenous biomolecules into an eye. The method generally has the steps of injecting, into a region of the eye, a mixture having a plurality of exogenous biomolecules and a plurality of plasmonic structures, the plasmonic structures having a plasmonic resonance wavelength, the plasmonic structures adjoining membranes of target cells in said region due to said injecting; and irradiating said region of said eye with a laser beam having a wavelength being offset to said plasmonic resonance wavelength, said irradiating causing the plasmonic structures to form pores in said membranes of said target cells, allowing at least some of the exogenous biomolecules to be delivered into the target cells via said pores.
Type:
Grant
Filed:
October 24, 2018
Date of Patent:
July 13, 2021
Assignee:
ÉCOLE POLYTECHNIQUE
Inventors:
Michel Meunier, Ariel Wilson, Éric Bergeron, Javier Mazzaferri, Santiago Costantino, Przemyslaw Sapieha
Abstract: The subject matter of the present invention is a microfluidic process for treating and analysing a solution containing a biological material, comprising a step of introducing the solution into microchannels of a microfluidic circuit (1), a step of forming drops of this solution, under the effect of modifications of the surface tension of the solution, a step of moving the drops to one or more drop storage zones(s) (130), under the effect of modifications of the surface tension of the drops, a step of treating the drops and a step of analysing the drops.
Type:
Grant
Filed:
October 18, 2017
Date of Patent:
December 10, 2019
Assignees:
École Polytechnique, Centre national de la recherche scientifique
Inventors:
Charles Baroud, Remi Dangla, Paul Abbyad, Silvan Turkcan
Abstract: Provided herein are microfluidic circuits that include at least one device for forming a quantity of drops of a solution in a carrier fluid and at least one storage zone for storing drops produced by the microfluidic device. Such microfluidic circuits are useful, for example, for the analysis of a solution containing a biological sample.
Type:
Grant
Filed:
October 8, 2013
Date of Patent:
November 14, 2017
Assignees:
École Polytechnique, Centre national de la recherche scientifique
Inventors:
Charles Baroud, Remi Dangla, Paul Abbyad, Silvan Turkcan