Abstract: Glycotargeting therapeutics are useful in the treatment of transplant rejection, autoimmune disease, food allergy, and immune response against a therapeutic agent.

Abstract: An analysis method for analyzing pressure exerted by a body portion and/or of a human prosthesis includes: sampling data generated by the body portion and/or the prosthesis during a threshold calibration period at a sampling frequency in a condition of use thereby obtaining an array of sampled data of at least one sensing unit; providing at least one threshold value of the sampled data for the condition of use and storing the least one threshold value in a memory unit; comparing at the sampling frequency the sampled data with the at least one threshold value to obtain calibrated data, and storing the calibrated data in the memory unit and/or sending the calibrated data to a computing device if the calibrated data is greater than the at least one threshold value. A sensing device for sensing the pressure exerted by a body portion and/or the human prosthesis is also provided.

Abstract: The invention relates to a photoplethysmography (PPG) sensing device comprising—a pulsed light source, —at least one pixel to create photo-generated electrons, synchronized with said pulsed light source. It is mainly characterized in that each pixel comprises: —a pinned photodiode (PPD) having two electronic connection nodes, —a sense node (SN), to convert the photo-generated electrons into a voltage, and—a Transfer Gate (TGtransfer) transistor, having its source electronically connected to one electronic connection node of said pinned photodiode (PPD), and being configured to act as a transfer gate (TG) between said pinned photodiode (PPD) and said sense node (SN), allowing the photo-generated electrons to sink when the light is pulsed-off, the photo-generated electrons integration when the light is pulsed-on and the transfer of at least part of the integrated photo-generated electrons to said sense node for a read-out.

Abstract: Glycotargeting therapeutics are useful in the treatment of transplant rejection, autoimmune disease, food allergy, and immune response against a therapeutic agent.

Abstract: The present disclosure relates to how to engineer reversible elasticity in thin films and/or layers and/or substrates, using a repeated Y-shaped motif, which is cut out through the film and/or layer and/or substrate. As an example, using a 75 ?m thick polyimide (PI) foil, macroscopic dog-bone shaped structures with a range of geometrical parameters of the Y shape have been prepared according to an embodiment of the present disclosure. The tensile strain response of the film at its point of fracture was then recorded. The structures were also confirmed using finite element modeling. Upon stretching, the PI ligaments locally deflect out of plane, allowing the foil to macroscopically stretch.

Abstract: Microfluidic network device (2) configured to supply reagents to a biological tissue sampling device (1), comprising a plurality of microfluidic inlet channels (12) connected to respective sources of said reagents, at least one common outlet channel (22), and a plurality of valves (36) interconnecting an outlet end (14) of each of said plurality of inlet channels to said at least one common outlet channel.

Abstract: In one embodiment, the exoskeleton structure is fastened to the body of the user by a brace and at the foot level. The exoskeleton includes at least one set of three joints corresponding to the hip abduction/adduction, the hip flexion/extension and the knee flexion/extension, wherein the architecture of the exoskeleton is compatible with a set of different removable, adaptable and backdrivable actuation units dedicated to each joints and remotely located around the trunk of the user to decrease inertia and mass on the distal segments, wherein each joint can be modularily let free, constrained by a visco-elastic mechanism or actuated by one corresponding actuation unit.

Abstract: The present invention relates to a method for preparing monomers via depolymerisation from lignocellulose-containing biomass.

Abstract: The invention provides in one embodiment a heat exchanger module (1) comprising a) a flexible support (100); b) at least one tubular member (200) having its main axis substantially parallel with the plane of the flexible support (100); c) a conductive flexible matrix (300) embedding the at least one tubular member (200); and d) a flexible case (400) enwrapping the flexible support (100), the at least one tubular member (200) and the conductive flexible matrix (300). A coating for a built environment comprising a plurality of heat exchanger modules (1) can be implemented, as well as a system further including pumping means (600). The invention also foresees a method for providing heat exchange processes between the heat exchanger module (1), the coating or the system of the invention and a built environment.

Abstract: A biomedical device having improved handling features to be easily inserted into a cavity or recess is disclosed, as well as methods for using thereof, said device comprising a flat and soft substrate, comprising electrically conductive tracks, configured to interface a biological surface; and a rigid member located on a portion of said flat and soft substrate, said member being substantially composed of a mechanically adaptive material being fully or partially degradable upon a degrading/softening trigger.

Abstract: The invention relates to a method for preparing PHFs-like Tau aggregates and to a method for identifying compounds that are inhibitors of Tau protein aggregation, blockers of Tau seeding and propagation, and imaging agents that specifically bind PHF.

Abstract: A composite multi-layer textile, comprising at least one nanofibre layer with nanofibres with diameters below 100 nm and one support layer with microfibres with diameters below three microns, wherein the layers were produced by electrospinning. The multi-layer textile shows a general transmittance at #=550 nm greater than 60%, which shows improved properties concerning transparency, breathability and robustness. This is achieved in that the at least one nanofibre layer and the support layer are fused, forming solid domains in the multi-layer textile, at closed areas of a pattern used in the production process, wherein the solid domains are separated from each other or connected, showing defined shapes, with regular or irregular spatial distribution, while the fibre morphology of nanofibres of the nanofibre layer and microfibres of support layer is preserved on top of the open areas beside the solid domains, attaining a general transmittance greater than that given by the sum of the individual layers.

Abstract: The invention relates to a method for manufacturing an electrode, preferably an implantable electrode array comprising the following steps: Applying (101) a layer of electrically conducting material (4) above a substrate material (1) for forming the electrically conductive traces; applying (102) a layer of insulating material (6) directly on top of the layer of electrically conducting material (4) for covering the electrically conductive traces; patterning (103) the layer of insulating material (4) by partly exposing the layer of electrically conducting material (4) to form at least one contact area (8) on the layer of the electrically conducting material (4), wherein a mask for patterning the layer of insulating material (6) defines a region (9) in the at least one contact area (8) at which the insulating material (6) in the at least one contact area (8) remains; and partly applying (104) a top layer (13) of electrically conducting material (4) at the contact area (8) on top of the layer of insulating materi

Abstract: In one aspect, a method includes generating a functional subgraph of a network from a structural graph of the network. The structural graph comprises a set of vertices and structural connections between the vertices. Generating the functional subgraph includes identifying a directed functional edge of the functional subgraph based on presence of structural connection and directional communication of information across the same structural connection.

Abstract: Consensus protocols for asynchronous networks are usually complex and inefficient, leading practical systems to rely on synchronous protocols. The invention proposes an approach to simplify asynchronous consensus by building it atop a novel threshold logical clock abstraction, allowing the consensus protocol to operate in “virtual synchrony.” Leveraging accountable state machine techniques to detect and suppress Byzantine nodes, and verifiable secret sharing for random leader election, we obtain simple and efficient protocols for asynchronous Byzantine consensus.

Abstract: The invention relates to a photoplethysmography (PPG) sensing device comprising —a pulsed light source, —at least one pixel to create photo-generated electrons, synchronized with said pulsed light source. It is mainly characterized in that each pixel comprises: —a pinned photodiode (PPD) having two electronic connection nodes, —a sense node (SN), to convert the photo-generated electrons into a voltage, and —a Transfer Gate (TGtransfer) transistor, having its source electronically connected to one electronic connection node of said pinned photodiode (PPD), and being configured to act as a transfer gate (TG) between said pinned photodiode (PPD) and said sense node (SN), allowing the photo-generated electrons to sink when the light is pulsed-off, the photo-generated electrons integration when the light is pulsed-on and the transfer of at least part of the integrated photo-generated electrons to said sense node for a read-out.

Abstract: Using a transformation based at least in part on a non-simple orthogonal or unitary matrix, data may be transmitted over a data bus in a manner that is resilient to one or more types of signal noise, that does not require a common reference at the transmission and acquisition points, and/or that has a pin-efficiency that is greater than 50% and may approach that of single-ended signaling. Such transformations may be implemented in hardware in an efficient manner. Hybrid transformers that apply such transformations to selected subsets of signals to be transmitted may be used to adapt to various signal set sizes and/or transmission environment properties including noise and physical space requirements of given transmission environments.

Abstract: An apparatus for patterned processing includes a source of input gas, a source of energy suitable for generating a plasma from the input gas in a plasma region and a grounded sample holder configured for receiving a solid sample. The apparatus includes a mask arranged between the plasma region and the grounded sample holder, the mask having a first face oriented toward the plasma region and a second face oriented toward a surface of the solid sample to be processed, the mask including a mask opening extending from the first face to the second face, and an electrical power supply adapted for applying a direct-current bias voltage to the mask, and the mask opening being dimensioned and shaped so as to generate spatially selective patterned processing on the surface of the solid sample.

Abstract: The invention discloses a microfluidic device for the culture, selection and/or analysis of sample organisms such as nematodes, as well as for other biological entities such as for instance animal embryos. The device features reservoirs, culture chambers and smart filtering systems allowing for the selection of specific populations/specimens of sample organisms, thus permitting long-term cultures thereof as well as phenotypic/behavioural analyses. Systems and methods for using the microfluidic device are within the present disclosure as well.

Abstract: The present invention relates to engineered extra-cellular vesicle internalizing receptors that have the ability to enhance uptake, processing, and presentation to T-cells of tumor-associated antigens by an antigen-presenting cell. It further relates to vectors or antigen presenting cells expressing said receptors, composition and uses thereof for the prevention and/or treatment of a cancer.