Abstract: at least one aurone or a natural or synthetic derivative of aurone, or an analogue of aurone, in which the independent phenyl ring can be substituted by a heterocycle of pyrrole, imidazole, triazole, pyridine, furan, or thiophene type, is disclosed as a cosmetic agent, or as an active substance, for the manufacture either of a cosmetic composition, or of a pharmaceutical composition, notably a dermatological composition, having a melanogenesis-inhibiting activity or a depigmenting activity, or an anti-tyrosinase activity.
Type:
Application
Filed:
May 12, 2005
Publication date:
October 12, 2006
Applicants:
Coletica, Universite Joseph Fourier-Grenoble 1
Abstract: a cell culture device is disclosed having at least one cell-supporting layer of porous material obtained by dehydration of an aqueous gel which is poured directly either into said well bottom or into the bottom of a cradle or insert of a size which is adapted for being insertable into the volume of the well, thereby enabling by a robot or an automaton itself commanded by you computer.
Type:
Application
Filed:
May 12, 2005
Publication date:
August 3, 2006
Applicants:
COLETICA, Centre National de la Recherche Scientifique
Inventors:
Eric Perrier, Odile Damour, Valerie Andre
Abstract: The invention relates to a method of in vitro testing of the efficacy of a potentially active substance comprising monitoring the effect of said potentially active substance on an artificial skin, comprising a composite product forming a collagen support comprising at least one porous collagen layer covered on at least one side with a collagen membrane component selected from the group consisting of a collagen membrane prepared by compression of a collagen sponge at a pressure of at least about 50 bar and of a collagen membrane comprising a collagen film prepared by drying a collagen gel separately from the porous collagen layer, thereby providing a reliable method for finding new potentially active substances.
Type:
Grant
Filed:
February 10, 2003
Date of Patent:
December 13, 2005
Assignee:
Coletica
Inventors:
Valerie Andre, Nabil Abdul Malak, Alain Huc
Abstract: The invention relates to novel hydrated lamellar phases or liposomes which contain either polyethylenimine, or a substance which stimulates intracellular penetration selected from the group consisting of: i) a fatty monoamine of carbon-containing chain length of between C10 and C18; ii) a cationic polymer, optionally at least one fluorescent compound which is essentially inert with respect to the intracellular penetration, which enables this penetration to be visualised. These liposomes are very useful in cosmetics or in pharmacy for stimulating the intracellular penetration of a substance or active principle.
Type:
Application
Filed:
June 30, 2004
Publication date:
December 1, 2005
Applicant:
COLETICA
Inventors:
Eric Perrier, Valerie Andre, Isabelle Bonnet
Abstract: The invention relates to a method of in vitro testing of the efficacy of a potentially active substance comprising monitoring the effect of said potentially active substance on an artificial skin, comprising a composite product forming a collagen support comprising at least one porous collagen layer covered on at least one side with a collagen membrane component selected from the group consisting of a collagen membrane prepared by compression of a collagen sponge at a pressure of at least about 50 bar and of a collagen membrane comprising a collagen film prepared by drying a collagen gel separately from the porous collagen layer, thereby providing a reliable method for finding new potentially active substances.
Type:
Application
Filed:
June 1, 2005
Publication date:
September 22, 2005
Applicant:
Coletica
Inventors:
Valerie Andre, Nabil Abdul Malak, Alain Huc
Abstract: The invention relates to the use of a Rhodiola crenulata extract, via the topical route, for increasing the energy metabolism of the cutaneous tissues of a subject. The invention relates notably to topical compositions which comprise an active agent for increasing the energy metabolism of the cutaneous tissues of a subject, said active agent being a Rhodiola crenulata extract. The present invention enables making a cosmetic care such as fighting against, or slowing down or preventing the loosening of the cutaneous tissue, increasing the plasticity of the cutaneous tissue, exerting an anti-wrinkle effect or slowing down or preventing the appearance of wrinkles, fighting against, slowing down or preventing the appearance of acne, exerting a depigmenting effect of the cutaneous tissue, in particular of the skin, and promoting desquamation of the cutaneous tissue (or “peeling”).
Type:
Application
Filed:
May 10, 2004
Publication date:
March 3, 2005
Applicant:
COLETICA
Inventors:
Eric Perrier, Sebastien Bonnet, Delphine Rival, Patrice Andre, Nancy About
Abstract: The invention relates to the stimulation of the activity of an isoform of lysyl oxidase, and more particularly of the LOX (lysyl oxidase) isoform.
Type:
Application
Filed:
May 24, 2004
Publication date:
December 23, 2004
Applicants:
COLETICA, CENTRE NATIONAL DE LA RECHERCHE
Abstract: The invention relates to the stimulation of the synthesis and of the activity of an isoform of lysyl oxidase, and more particularly of the LOXL (Iysyl oxidase-like) isoform.
Type:
Application
Filed:
May 24, 2004
Publication date:
December 16, 2004
Applicants:
COLETICA, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Abstract: The invention relates to novel amphiphilic complexes, a method for their preparation, and the compositions containing them. Said amphiphilic complexes result from the reaction, at a temperature between ambient temperature and 80° C., between a protein or polypeptide whose average molecular mass is greater than or equal to 5,000 Daltons and a fatty chain whose carbon atom number is between 4 and 30 selected from fatty acid, fatty alcohol, fatty amine, with the exclusion of undecylenic acid ; the protein or polypeptide/fatty chain weight ratio ranging from 1000/1 to 1/10.
Type:
Application
Filed:
March 8, 2004
Publication date:
December 2, 2004
Applicant:
COLETICA
Inventors:
Eric Perrier, Alain Huc, Danielle Antoni, Coralie Roussel, Michel Pina, Jean Graille
Abstract: A composite product is disclosed as a collagen support comprising at least one porous collagen layer covered on at least one side with an essentially compact collagen membrane consisting either of a collagen film prepared by drying a collagen gel, preferably in air or a gaseous fluid, or of a very highly compressed collagen sponge. At least one of the two layers, i.e. the porous layer and the essentially compact membrane, may comprise normal, genetically modified or malignant living cells originating particularly from young or elderly subjects. This composite product is used as a collagen support for the manufacture of artificial skin intended especially for performing in vitro tests on the efficacy of potentially active substances or for reconstructing damaged areas of skin in vivo.
Type:
Grant
Filed:
July 14, 2000
Date of Patent:
September 14, 2004
Assignee:
Coletica
Inventors:
Nabil Abdul Malak, Valérie Andre, Alain Huc
Abstract: The invention relates mainly to a particle comprising at least one biopolymer which is degradable under the effect of an electromagnetic wavelength, notably the wavelength of which is in the spectrum of the wavelengths emitted by the sun, this biopolymer comprising nucleosides. The invention also relates to compositions containing such particles with the aim of delivering an active principle.
Type:
Application
Filed:
January 15, 2003
Publication date:
June 24, 2004
Applicant:
COLETICA
Inventors:
Eric Perrier, Isabelle Bonnet, Charlotte De Matteis
Abstract: The invention relates mainly to a method of testing the activity of a potentially active substance to inhibit the enzymatic activity of phospholipase A2.
Type:
Application
Filed:
February 12, 2003
Publication date:
May 20, 2004
Applicant:
COLETICA
Inventors:
Eric Perrier, Sebastien Bonnet, Delphine Rival
Abstract: The invention relates to active ingredients capable of stimulating direct or indirect expression of type 2 human beta-defensins and/or type 3 human beta-defensins.
Type:
Application
Filed:
November 25, 2002
Publication date:
May 13, 2004
Applicants:
COLETICA, YSL BEAUTE
Inventors:
Eric Perrier, Anne Guezennec, Ingrid Pernet, Corinne Reymermier, Joelle Guesnet
Abstract: Cosmetic and pharmaceutical compositions comprising amphiphilic or hydrolipidic complexes of plant proteins modified with fatty chains are presented. The modified proteins are obtained from the reaction carried out at a temperature between ambient temperature and 80° C. with plant proteins having an average molecular mass is greater than or equal to 10,000 Daltons and one or more fatty chains whose carbon atom number is between 4 and 30, selected from fatty acid anhydrides and fatty acid halides, with the exclusion of undecylenic acid.
Type:
Grant
Filed:
June 17, 1997
Date of Patent:
March 9, 2004
Assignee:
Coletica
Inventors:
Eric Perrier, Alain Huc, Danielle Antoni, Coralie Roussel, Michel Pina, Jean Graille
Abstract: The invention relates to a method of in vitro testing of the efficacy of a potentially active substance comprising monitoring the effect of said potentially active substance on an artificial skin, comprising a composite product forming a collagen support comprising at least one porous collagen layer covered on at least one side with a collagen membrane component selected from the group consisting of a collagen membrane prepared by compression of a collagen sponge at a pressure of at least about 50 bar and of a collagen membrane comprising a collagen film prepared by drying a collagen gel separately from the porous collagen layer, thereby providing a reliable method for finding new potentially active substances.
Type:
Application
Filed:
February 10, 2003
Publication date:
January 1, 2004
Applicant:
COLETICA
Inventors:
Valerie Andre, Nabil Abdul Malak, Alain Huc
Abstract: The invention relates to a collagen product containing collagen of marine origin with a low odor. The collagen product includes one or more collagens or derivatives thereof, including hydrolyzates, with a low odor, at least part of the collagen or the derivatives being of marine origin and having been subjected to a deodorization treatment, particularly with an oxidizing substance such as a sulfite, hydrogen peroxide or ozone, at any stage of the manufacture of the collagen product. The invention also makes it possible to improve the mechanical properties and to use this low-odor collagen product in cosmetic or pharmaceutical products.
Type:
Grant
Filed:
November 9, 1999
Date of Patent:
December 9, 2003
Assignee:
Coletica
Inventors:
Roland Allard, Nabil Abdul Malak, Alain Huc
Abstract: Non-hydroxyalkylated cyclodextrins are disclosed wherein at least one primary alcohol function (CH2OH) is substituted, the —OH portion being replaced by a substituent with formula —O—CO—R or —NR1R2, where: R, R1 and R2 independently represent a linear or cyclic, saturated or unsaturated, hydroxylated or non-hydroxylated alkyl group containing 1 to 30 carbon atoms, preferably 1 to 22 carbon atoms, more preferably a fatty chain containing 2 to 22 carbon atoms. These cyclodextrins are used as vectors for at least one active ingredient, in particular to encourage tissue penetration, in a cosmetic application, or for the production of pharmaceutical compositions, in particular dermopharmaceuticals.
Type:
Application
Filed:
December 13, 2002
Publication date:
August 14, 2003
Applicant:
COLETICA
Inventors:
Eric Perrier, Nicolas Terry, Delphine Rival, Anthony William Coleman