Abstract: Methods of treating or preventing diseases caused by viral infections via the administration of pyronaridine, quinacrine, and/or tilorone are described. The viral infections can be caused by viruses such as Marburg virus (MARV), Chikungunya virus (CHIKV), norovirus, Middle East Respiratory Syndrome coronavirus (MERS-CoV), and Nipah virus.
Type:
Application
Filed:
July 10, 2023
Publication date:
January 11, 2024
Applicant:
Collaborations Pharmaceuticals, Inc.
Inventors:
Sean Ekins, Thomas R. Lane, Ana C. Puhl
Abstract: Methods of treating or preventing diseases caused by viral infections via the administration of pyronaridine, quinacrine, and/or tilorone are described. The viral infections can be caused by viruses such as Marburg virus (MARV), Chikungunya virus (CHIKV), norovirus, Middle East Respiratory Syndrome coronavirus (MERS-CoV), and Nipah virus.
Type:
Grant
Filed:
November 6, 2020
Date of Patent:
July 11, 2023
Assignee:
Collaborations Pharmaceuticals, Inc.
Inventors:
Sean Ekins, Thomas R. Lane, Ana C. Puhl Rubio
Abstract: Methods of modulating the interaction between ?-amyloid and ?7-nAChR are provided. Aspects of the methods include administering to the subject an effective amount of a naphthalene derivative active agent. Compositions and kits for practicing the subject methods are also provided. The methods, compositions and kits find use in treating a variety of applications, such as treating a subject for a neurodegenerative disease, e.g., Alzheimer's disease.
Type:
Grant
Filed:
April 5, 2018
Date of Patent:
July 12, 2022
Assignees:
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Collaborations Pharmaceuticals, Inc.
Inventors:
Aaron McMurtray, Julia Chung, Natalie Diaz, Sean Ekins