Patents Assigned to Collagen Matrix, Inc.
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Patent number: 11969349Abstract: An implant for the repair of bone and cartilage that includes a cell conductive zone that contains biopolymeric fibers and an osteoconductive zone that contains biopolymeric fibers and calcium-containing mineral particles. The biopolymeric fibers from one zone overlap with the fibers in the other zone forming a stable physical and mechanical integration of the two zones, thus conferring in vivo stability to the implant.Type: GrantFiled: March 12, 2021Date of Patent: April 30, 2024Assignee: Collagen Matrix, Inc.Inventors: Shu-Tung Li, Hui-Chen Chen, Debbie Yuen
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Publication number: 20230348567Abstract: Disclosed are methods for forming targeted collagen products having an amplified desired characteristic, including the step of adding peptides exhibiting a desired characteristic to collagen to form the targeted collagen product. Further disclosed are methods for forming a targeted collagen product lacking an undesired characteristic, including the step of subtracting peptides exhibiting the undesired characteristic from collagen to form the targeted collagen product. Also disclosed are targeted collagen products formed by the disclosed methods.Type: ApplicationFiled: September 9, 2021Publication date: November 2, 2023Applicant: COLLAGEN MATRIX, INC.Inventors: Natsuyo Shishido Lee, Daniel Ammon, Hui-Chen Chen
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Publication number: 20230212264Abstract: Disclosed are methods for forming targeted collagen products having an amplified desired characteristic, including the step of adding peptides exhibiting a desired characteristic to collagen to form the targeted collagen product. The adding step is performed so that the collagen is crosslinked to the peptide exhibiting the desired characteristic. Crosslinking of the collagen to the peptide exhibiting the desired characteristic occurs by modification of the peptide to facilitate binding to the collagen. Further disclosed are methods for forming a targeted collagen product lacking an undesired characteristic, including the step of subtracting peptides exhibiting the undesired characteristic from collagen to form the targeted collagen product. Also disclosed are targeted collagen products formed by the disclosed methods.Type: ApplicationFiled: December 30, 2022Publication date: July 6, 2023Applicant: COLLAGEN MATRIX, INC.Inventors: Natsuyo Shishido Lee, Daniel Ammon, Hui-Chen Chen, Joseph Chinn, Diana Legarda
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Publication number: 20210402056Abstract: A bone graft substitute which combines substantially the high mechanical stability of spherical porous granules without the limitation of reduced intergranular space. The granules have a high porosity whilst maintaining high stability, and can be pushed into a defect without risking significant breakage of the granules and, simultaneously, bone cells can grow into the space between the granules. In an exemplary embodiment of the invention, the surface of the granules comprises indentations, when viewed from the exterior of the granules. An indentation increases the porosity within the implanted mass significantly and thus provides more space between the granules for tissue ingrowth. Due to the indentations on the granules, the granules have an irregular shape and thus an increase in the intergranular space is achieved, while mechanical stability is maintained. A biocompatible polymer, such as a collagen or gelatin, is disposed about at least some of the granules to form a coating thereon.Type: ApplicationFiled: September 13, 2021Publication date: December 30, 2021Applicant: COLLAGEN MATRIX, INC.Inventors: Lukas Pfister, Kurt Ruffieux, Urs Ebneter
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Publication number: 20210283301Abstract: A bone graft substitute which combines substantially the high mechanical stability of spherical porous granules without the limitation of reduced intergranular space, and a method for manufacturing the bone graft substitute. In an exemplary embodiment of the invention, the surface of the granules comprises indentations that increases the porosity within the implanted mass significantly and thus provides more space between the granules for tissue ingrowth. The indentations on the granules cause them to have an irregular shape and thus an increase in the intergranular space is achieved, while mechanical stability is maintained. An exemplary method according to the invention includes the steps of manufacturing the granules; mixing the granules with a porogen; pressing the porogen into the surface of at least a portion of the granules; and removing the porogen from the implant mass to form the indentations in the surface where the porogen was pressed into the granules.Type: ApplicationFiled: May 27, 2021Publication date: September 16, 2021Applicant: Collagen Matrix, Inc.Inventors: Lukas Pfister, Kurt Ruffieux
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Publication number: 20210236689Abstract: A bone graft substitute which combines substantially the high mechanical stability of spherical porous granules without the limitation of reduced intergranular space. The granules have a high porosity whilst maintaining high stability, and can be pushed into a defect without risking significant breakage of the granules and, simultaneously, bone cells can grow into the space between the granules. In an exemplary embodiment of the invention, the surface of the granules comprises indentations, when viewed from the exterior of the granules. An indentation increases the porosity within the implanted mass significantly and thus provides more space between the granules for tissue ingrowth. Due to the indentations on the granules, the granules have an irregular shape and thus an increase in the intergranular space is achieved, while mechanical stability is maintained. A biocompatible polymer, such as a polypeptide, is disposed about at least some of the granules to form a coating thereon.Type: ApplicationFiled: April 19, 2021Publication date: August 5, 2021Applicant: Collagen Matrix, Inc.Inventors: Lukas PFISTER, Kurt RUFFIEUX
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Patent number: 10945846Abstract: An implant for the repair of bone and cartilage that includes a cell conductive zone that contains biopolymeric fibers and an osteoconductive zone that contains biopolymeric fibers and calcium-containing mineral particles. The biopolymeric fibers from one zone overlap with the fibers in the other zone forming a stable physical and mechanical integration of the two zones, thus conferring in vivo stability to the implant.Type: GrantFiled: August 19, 2016Date of Patent: March 16, 2021Assignee: Collagen Matrix, Inc.Inventors: Shu-Tung Li, Hui-Chen Chen, Debbie Yuen
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Patent number: 10537417Abstract: A density gradient biopolymeric matrix implant is disclosed. The implant includes a first homogeneous matrix layer and a second homogeneous matrix layer having a density different from that of the first homogeneous matrix layer. Biopolymeric fibers at the surface of the first homogeneous matrix layer are physically in contact with and cross-linked to the biopolymeric fibers at the surface of the second homogeneous matrix layer. Also disclosed is a three-dimensional density gradient biopolymeric matrix implant that includes a first homogeneous matrix surrounding a second homogeneous matrix having a different density. Biopolymeric fibers at an inner surface of the first homogeneous matrix are physically in contact with and cross-linked to biopolymeric fibers at an outer surface of the second homogeneous matrix. Furthermore, methods for preparing the density gradient biopolymeric matrix implant and the three-dimensional density gradient biopolymeric matrix implant are provided.Type: GrantFiled: July 7, 2016Date of Patent: January 21, 2020Assignee: Collagen Matrix, Inc.Inventors: Shu-Tung Li, Natsuyo Shishido Lee, Debbie Yuen
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Patent number: 10286104Abstract: A carbonate apatite prepared from natural bone. The carbonate apatite has a protein content of 2000-8000 parts per million and a surface area of 15 to 70 m2/g. Also provided is a method for preparing the carbonate apatite from cancellous bone particles.Type: GrantFiled: March 6, 2017Date of Patent: May 14, 2019Assignee: Collagen Matrix, Inc.Inventors: Shu-Tung Li, Hui-Chen Chen, Debbie Yuen
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Patent number: 10279077Abstract: A collagen-coated tissue based membrane that is smooth on both sides so as to inhibit cell and tissue adhesion. Also disclosed are methods for making a collagen-coated tissue-based membrane.Type: GrantFiled: August 13, 2018Date of Patent: May 7, 2019Assignee: Collagen Matrix, Inc.Inventors: Shu-Tung Li, Debbie Yuen
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Patent number: 10071184Abstract: A collagen-coated tissue-based membrane that is smooth on both sides so as to inhibit cell and tissue adhesion. The tissue-based membrane is a serous membrane having a fibrous surface and a smooth surface and the collagen is coated on the fibrous surface. Also provided are methods for making the collagen-coated tissue-based membrane.Type: GrantFiled: February 29, 2012Date of Patent: September 11, 2018Assignee: Collagen Matrix, Inc.Inventors: Shu-Tung Li, Debbie Yuen
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Patent number: 9308219Abstract: A flat self-curling permeable sheet membrane containing a matrix formed of crosslinked biopolymeric fibers. The matrix self-curls into a predetermined shape upon absorption of an aqueous fluid and is permeable to molecules having molecular weights not greater than 1×106 daltons. Also disclosed is a method of preparing such a flat self-curling permeable membrane.Type: GrantFiled: June 30, 2011Date of Patent: April 12, 2016Assignee: Collagen Matrix, Inc.Inventors: Shu-Tung Li, Natsuyo Shishido Lee, Debbie Yuen
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Patent number: 9061464Abstract: A re-rollable membrane for wrapping around and protecting a cylindrical tissue having an injury site. The membrane includes a sheet of a porous matrix formed of cross-linked biopolymeric fibers. In one implementation, the sheet can be spirally rolled so that at least one portion overlaps another portion of the sheet and, upon absorption of a fluid, the overlapping portions adhere to each other closely so as to exclude penetration of cells. In another implementation, the sheet can be helically rolled to form a helix having a pitch of 2 mm to 40 mm and an inner diameter of 1 mm to 50 mm. Also disclosed are methods for making and using such re-rollable membranes.Type: GrantFiled: September 3, 2008Date of Patent: June 23, 2015Assignee: Collagen Matrix, Inc.Inventors: Shu-Tung Li, Debbie Yuen
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Patent number: 8980328Abstract: A method for preparing carbonate apatite from natural bones. The method includes obtaining cancellous bone particles; treating the bone particles with hot water and an organic solvent; repeating the treating step at least once; drying the bone particles; and heating the bone particles at 500° C. to 620° C. for 10 to 50 hours.Type: GrantFiled: September 29, 2011Date of Patent: March 17, 2015Assignee: Collagen Matrix, Inc.Inventors: Shu-Tung Li, Hui-Chen Chen, Debbie Yuen
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Patent number: 8877220Abstract: A compressed implant composite for repairing mineralized tissue. The compressed implant composite includes a matrix formed of biopolymeric fibers and a plurality of calcium- and/or silicate-based mineral particles dispersed in the matrix. The matrix constitutes 4 to 80% by weight and the mineral particles constitute 20 to 96% by weight of the composite. The composite is free of soluble collagen and is expandable to a volume 2 to 100 times of its compressed volume (e.g., upon absorption of water). Also disclosed are methods of preparing the above-described composite.Type: GrantFiled: August 5, 2010Date of Patent: November 4, 2014Assignee: Collagen Matrix, Inc.Inventors: Shu-Tung Li, Hui-Chen Chen, Debbie Yuen
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Patent number: 8821917Abstract: This invention relates to a sheet membrane for repairing a damaged tissue. The membrane includes an isotropic layer of cross-linked biopolymeric fibers in which the fibers are 10 to 1,000 cm in length. This invention also relates to a method of making an isotropic layer of cross-linked biopolymeric fibers. The method includes: (1) coacervating biopolymeric fibers (e.g., collagen-based fibers) having lengths of less than 1 cm dispersed in an aqueous solution to obtain coacervated biopolymeric fibers having lengths of 10 to 1,000 cm; (2) flattening the coacervated biopolymeric fibers into a layer; (3) drying the layer; and (4) cross-linking the biopolymeric.Type: GrantFiled: October 4, 2010Date of Patent: September 2, 2014Assignee: Collagen Matrix, Inc.Inventors: Shu-Tung Li, Debbie Yuen, Peggy Hansen
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Publication number: 20130345729Abstract: A compression and kink resistant tubular implant for nerve repair. The implant includes a tubular biopolymeric membrane and a polymeric supporting filament. Also provided is a shaped compression resistant implant for ridge augmentation in dental surgery. Methods for producing the implants are also provided.Type: ApplicationFiled: June 22, 2012Publication date: December 26, 2013Applicant: Collagen Matrix, Inc.Inventors: Shu-Tung Li, Debbie Yuen
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Publication number: 20130345826Abstract: An implant for the repair of bone and cartilage that includes a cell conductive zone that contains biopolymeric fibers and an osteoconductive zone that contains biopolymeric fibers and calcium-containing mineral particles. The biopolymeric fibers from one zone overlaps with the fibers in the other zone forming a stable physical and mechanical integration of the two zones thus conferring in vivo stability to the implant.Type: ApplicationFiled: June 22, 2012Publication date: December 26, 2013Applicant: Collagen Matrix, Inc.Inventors: Shu-Tung Li, Hui-Chen Chen, Debbie Yuen
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Publication number: 20130226314Abstract: A collagen-coated tissue based membrane that is smooth on both sides so as to inhibit cell and tissue adhesion. Also disclosed are methods for making a collagen-coated tissue-based membrane.Type: ApplicationFiled: February 29, 2012Publication date: August 29, 2013Applicant: Collagen Matrix, Inc.Inventors: Shu-Tung Li, Debbie Yuen
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Publication number: 20130084228Abstract: A method for preparing carbonate apatite from natural bones. The method includes obtaining cancellous bone particles; treating the bone particles with hot water and an organic solvent; repeating the treating step at least once; drying the bone particles; and heating the bone particles at 500° C. to 620° C. for 10 to 50 hours.Type: ApplicationFiled: September 29, 2011Publication date: April 4, 2013Applicant: COLLAGEN MATRIX, INC.Inventors: Shu-Tung Li, Hui-Chen Chen, Debbie Yuen