Patents Assigned to College
  • Patent number: 11104937
    Abstract: The embodiments disclosed herein utilized RNA targeting effectors to provide a robust CRISPR-based diagnostic with attomolar sensitivity. Embodiments disclosed herein can detect broth DNA and RNA with comparable levels of sensitivity and can differentiate targets from non-targets based on single base pair differences. Moreover, the embodiments disclosed herein can be prepared in freeze-dried format for convenient distribution and point-of-care (POC) applications. Such embodiments are useful in multiple scenarios in human health including, for example, viral detection, bacterial strain typing, sensitive genotyping, and detection of disease-associated cell free DNA.
    Type: Grant
    Filed: March 15, 2018
    Date of Patent: August 31, 2021
    Assignees: The Broad Institute, Inc., Massachusetts Institute of Technology, President and Fellows of Harvard College, The General Hospital Corporation
    Inventors: Omar Abudayyeh, James Joseph Collins, Jonathan Gootenberg, Feng Zhang, Eric S. Lander, Roby Bhattacharyya, Deborah Hung
  • Patent number: 11106186
    Abstract: Aspects of the present disclosure include anonymous, asynchronous, and randomized control schemes for distributed energy resources (DERs). Such control schemes may include packetized energy management (PEM) control schemes for managing DERs that may provide near-optimal tracking performance under imperfect information and consumer quality of service (QoS) constraints.
    Type: Grant
    Filed: May 23, 2019
    Date of Patent: August 31, 2021
    Assignee: University of Vermont and State Agricultural College
    Inventors: Jeffrey Frolik, Paul Hines, Mads Almassalkhi
  • Patent number: 11104892
    Abstract: Embodied herein are engineered fusion proteins that bind and target nociceptor neurons, compositions comprising these engineered fusion proteins, and methods for treatment of pain using these engineered fusion proteins or compositions containing the engineered fusion proteins. The engineered fusion proteins contain domains derived from protein toxins such as the anthrax toxin, clostridial botulinum family of toxins, disulphide-containing toxins, and AB component type toxins.
    Type: Grant
    Filed: May 27, 2020
    Date of Patent: August 31, 2021
    Assignees: President and Fellows of Harvard College, Massachusetts Institute of Technology
    Inventors: R. John Collier, Isaac Chiu, Bradley L. Pentelute
  • Patent number: 11104926
    Abstract: Provided are N,N?-diacyl rhodamine compounds, which may be converted to rhodamine by porcine liver esterase (PLE) to produce a fluorescence signal. These compounds may be used, for example, as substrates in enzymatic assays or as labels in cellular imaging.
    Type: Grant
    Filed: March 26, 2019
    Date of Patent: August 31, 2021
    Assignees: Vanderbilt University, Meharry Medical College
    Inventors: Gary A. Sulikowski, Kristopher K. Abney, Susan J. Ramos-Hunter, Ian M. Romaine, Charles David Weaver
  • Patent number: 11104883
    Abstract: Disclosed herein are methods, compositions, kits, and agents useful for inducing ? cell maturation, and isolated populations of SC-? cells for use in various applications, such as cell therapy.
    Type: Grant
    Filed: July 21, 2020
    Date of Patent: August 31, 2021
    Assignee: President and Fellows of Harvard College
    Inventors: Quinn P. Peterson, Felicia J. Pagliuca, Douglas A. Melton, Jeffrey R. Millman, Michael Saris Segel, Mads Gurtler
  • Patent number: 11104967
    Abstract: Some aspects of the present disclosure provide methods for evolving recombinases to recognize target sequences that differ from the canonical recognition sequences. Some aspects of this disclosure provide evolved recombinases, e.g., recombinases that bind and recombine naturally-occurring target sequences, such as, e.g., target sequences within the human Rosa26 locus. Methods for using such recombinases for genetically engineering nucleic acid molecules in vitro and in vivo are also provided. Some aspects of this disclosure also provide libraries and screening methods for assessing the target site preferences of recombinases, as well as methods for selecting recombinases that bind and recombine a non-canonical target sequence with high specificity.
    Type: Grant
    Filed: July 24, 2019
    Date of Patent: August 31, 2021
    Assignee: President and Fellows of Harvard College
    Inventors: David R. Liu, David B. Thompson, Jeffrey L. Bessen
  • Patent number: 11103686
    Abstract: Systems and methods for creating microneedle arrays capable of delivering a suitable drug dosages to subjects are provided. In one aspect, a method comprises creating at least one forming mold using laser ablation in a cross-over line pattern. The method further comprises casting a first material onto the at least one forming mold to create at least one microneedle mold. The method further comprises casting a second material onto the at least one microneedle mold to create at least one hollow microneedle.
    Type: Grant
    Filed: October 16, 2018
    Date of Patent: August 31, 2021
    Assignee: Trustees of Tufts College
    Inventors: Hojatollah Rezaei Nejad, Aydin Sadeqi, Sameer Sonkusale
  • Publication number: 20210263027
    Abstract: Articles and methods involving fluidic devices are generally provided. In some embodiments, a fluidic device comprises a first layer comprising a central region in fluidic communication with an environment external to the fluidic device. The first layer may also comprise a first channel and a second channel in fluidic communication with the central region and extending radially outwards therefrom. The first and second channels may comprises first and second sample regions from which first and second samples can be removed from the fluidic device. In some embodiments, a fluidic device comprises a first layer and a second, filtration layer configured to separate blood cells from plasma positioned between the environment external to the fluidic device and the first layer.
    Type: Application
    Filed: June 19, 2019
    Publication date: August 26, 2021
    Applicant: Trustees of Tufts College
    Inventors: Charles R. Mace, Jessica C. Brooks, Syrena C. Fernandes, Keith Baillargeon
  • Publication number: 20210262970
    Abstract: In some embodiments, the present disclosure pertains to methods of detecting an analyte in a sample by associating the sample with an electrode that includes a metal-organic framework. After association, the redox properties of the electrode are evaluated. Thereafter, the presence or absence of the analyte in the sample is detected by correlating the redox properties of the electrode to the presence or absence of the analyte. In some embodiments, the present disclosure pertains to electrodes that include a metal-organic framework and an electrode surface. In particular embodiments of the present disclosure, the metal-organic framework is associated with the electrode surface. Additional embodiments of the present disclosure pertain to methods of making the electrodes of the present disclosure by associating a metal-organic framework with an electrode surface. In some embodiments, the methods of the present disclosure also include a step of mixing the metal-organic framework with a polymer.
    Type: Application
    Filed: June 21, 2019
    Publication date: August 26, 2021
    Applicant: Trustees of Dartmouth College
    Inventors: Katherine A. Mirica, Lukasz K. Mendecki, Michael Ko, Zheng Meng, Robert M. Stolz, Aileen Eagleton
  • Publication number: 20210261566
    Abstract: The present invention provides novel Compound (1) having tumor vascular remodeling effect and/or anti-CAF (Cancer Associated Fibroblasts) activity, or a pharmaceutically acceptable salt thereof, optionally in a pharmaceutically acceptable carrier, and medical uses thereof.
    Type: Application
    Filed: February 4, 2021
    Publication date: August 26, 2021
    Applicants: President and Fellows of Harvard College, Eisai R&D Management Co., LTD.
    Inventors: Yoshito Kishi, Kazunobu Kira, Ken Ito
  • Publication number: 20210262011
    Abstract: Methods of making a three-dimensional matrix of nucleic acids within a cell is provided.
    Type: Application
    Filed: April 23, 2021
    Publication date: August 26, 2021
    Applicants: President and Fellows of Harvard College, President and Fellows of Harvard College
    Inventors: George M. Church, Jehyuk Lee, Daniel Levner, Michael Super
  • Publication number: 20210261930
    Abstract: Methods, systems, compositions and strategies for the delivery of WW domain-containing fusion proteins into cells in vivo, ex vivo, or in vitro via ARMMs are provided. Methods, systems, compositions and strategies for the delivery of Cas9 proteins and/or Cas9 variants into cells in vivo, ex vivo, or in vitro via fusion to ARMM associated proteins (e.g., ARRDC1 or TSG101) are also provided.
    Type: Application
    Filed: February 5, 2021
    Publication date: August 26, 2021
    Applicants: President and Fellows of Harvard College, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Quan Lu, Qiyu Wang, Stanley N. Cohen
  • Publication number: 20210261938
    Abstract: Some aspects of this disclosure relate to strategies, systems, methods, compositions, and kits that are useful for production (e.g., evolution) of cytidine deaminase protein variants that are characterized by increased soluble expression and/or stability relative to the wild-type cytidine deaminase protein from which they are evolved. In some embodiments, evolved cytidine deaminase variants described by the disclosure are useful for incorporation into targeted nucleic acid editing proteins, for example in fusion proteins with a Cas9 domain or variant thereof.
    Type: Application
    Filed: June 14, 2019
    Publication date: August 26, 2021
    Applicant: President and Fellows of Flarvard College
    Inventors: David R. Liu, Tina Wang
  • Patent number: 11097090
    Abstract: Methods and apparatuses relate to an implantable device for providing contractile assistance to an organ. The device may include an actuator and anchors located on either side of the actuator. The anchors engage with oppositely positioned tissue walls of an organ chamber, and provide contractile assistance to the organ, repeatedly, at appropriate times. For example, the device may be implanted within the right ventricle, anchored to the right ventricular free wall and the ventricular septum. The device may function to bring the opposing walls of the ventricle toward one another, synchronized with the pacing of the heart, resulting in an improved ejection fraction of blood from the chamber. In some embodiments, the actuator includes a bladder that is configured to contract upon receiving an inflow of pressurized fluid therein. When the fluid exits therefrom, the bladder relaxes back to an initial, extended state.
    Type: Grant
    Filed: March 28, 2018
    Date of Patent: August 24, 2021
    Assignees: President and Fellows of Harvard College, Children's Medical Center Corporation
    Inventors: Nikolay V. Vasilyev, Pedro J. del Nido, Tonatiuh M. Lievano Beltran, Erik A. Kraus, Nikhil Mehandru, Evelyn J. Park, Conor J. Walsh, Isaac Wamala, Markus Horvath
  • Patent number: 11099210
    Abstract: A method of carrying out sub-resonant tapping in an atomic force microscope includes causing a probe that is disposed above a sample to be translated in a direction parallel to a horizontal plane defined by the sample and to oscillate in a vertical direction that is perpendicular to the horizontal plane about an equilibrium line that is separated from the horizontal plane by a vertical offset. As a result, the probe repeatedly taps a surface of the sample. Each tap begins with a first contact of the probe on the surface followed by a progressive increase in force exerted by the sample on the probe until a peak force is attained. The vertical offset is controlled by relying at least in part on a feature other than the peak force as a basis for controlling the vertical offset.
    Type: Grant
    Filed: January 30, 2018
    Date of Patent: August 24, 2021
    Assignee: Trustees of Tufts College
    Inventors: Piers Echols-Jones, William C. Messner, Igor Sokolov
  • Patent number: 11098021
    Abstract: Described herein are phenylsulfonamido-benzofuran derivatives, and pharmaceutically acceptable salts thereof. Also provided are pharmaceutical compositions, methods, uses, and kits involving compounds of Formulae (I), (II), (III), (IV), (V), or (VI) for treating and/or preventing proliferative diseases (e.g. cancers, inflammatory diseases, and autoimmune diseases) in a subject. The compounds and pharmaceutical compositions as described herein inhibit at least one protein of the BCL-2 family in a biological sample or subject to treat and/or prevent a proliferative disease. In certain embodiments, compounds described herein are selective inhibitors of MCL-1, a BCL-2 family member protein.
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: August 24, 2021
    Assignees: Memorial Sloan-Kettering Cancer Center, Albert Einstein College of Medicine, Inc.
    Inventors: Emily H. Cheng, Paul Jeng, Ouathek Ouerfelli, James Hsieh, Guangli Yang, Evripidis Gavathiotis
  • Patent number: 11096924
    Abstract: Disclosed are combination therapies including administration of I-DASH inhibitors and PGE2 antagonists, and the use of such therapies in the treatment of cell proliferative diseases.
    Type: Grant
    Filed: September 7, 2017
    Date of Patent: August 24, 2021
    Assignee: Trustees of Tufts College
    Inventors: William W. Bachovchin, Hung-sen Lai, Wengen Wu
  • Patent number: 11100893
    Abstract: The present invention discloses an eye protection method and system for an intelligent terminal, which uses a light sensor to acquire ambient light, uses a distance sensor to acquire a distance between a user's eyes and a screen of the intelligent terminal, uses a camera to identify a user identity, and uses eye protection software to monitor display content and perform data analysis, thereby achieving automatic adjustment of screen brightness, automatic adjustment of screen color temperature, adjustment of display mode, automatic restriction of use time, switching to basic communication function, and so on. The present invention intelligently adjusts the eye protection threshold, improves the practicability and effectiveness of the eye protection method, and improves the experience effect of the user's eye protection function.
    Type: Grant
    Filed: January 3, 2020
    Date of Patent: August 24, 2021
    Assignee: Chinese Academy of Medical Sciences & Peking Union Medical College, Institute of Biomedical Engineering
    Inventors: Yingxin Li, He Huang, Huijuan Yin, Xiaoxi Dong
  • Patent number: 11101915
    Abstract: The subject method for delivering power to a moving target wirelessly via electromagnetic time reversal can find applications in wireless electrical transmission to portable devices, wireless heating of portable devices, novel wirelessly powered accelerometers, hyperthermic treatment of cancers, and many other applications. The subject non-linear time reversed electromagnetic waves based wireless power transmission (WPT) system targets either a single linear or non-linear object where a selective targeting between two diodes has been demonstrated simultaneously with different degrees of non-linearity in a three-dimensional ray-chaotic billiard model. A dual-purpose rectenna with harmonic generation for wireless power transfer by non-linear time-reversal has been designed for the subject system using the Schottky diode.
    Type: Grant
    Filed: April 25, 2017
    Date of Patent: August 24, 2021
    Assignee: University of Maryland, College Park
    Inventors: Steven Mark Anlage, Frank Cangialosi, Tyler Grover, Andrew Simon, Scott Roman, Liangcheng Tao
  • Patent number: 11098303
    Abstract: The present invention generally relates to systems and methods for imaging or determining nucleic acids, for instance, within cells. In some embodiments, the transcriptome of a cell may be determined. Certain embodiments are directed to determining nucleic acids, such as mRNA, within cells at relatively high resolutions. In some embodiments, a plurality of nucleic acid probes may be applied to a sample, and their binding within the sample determined, e.g., using fluorescence, to determine locations of the nucleic acid probes within the sample. In some embodiments, codewords may be based on the binding of the plurality of nucleic acid probes, and in some cases, the codewords may define an error-correcting code to reduce or prevent misidentification of the nucleic acids. In certain cases, a relatively large number of different targets may be identified using a relatively small number of labels, e.g., by using various combinatorial approaches.
    Type: Grant
    Filed: July 29, 2015
    Date of Patent: August 24, 2021
    Assignee: President and Fellows of Harvard College
    Inventors: Xiaowei Zhuang, Kok-Hao Chen, Alistair Boettiger, Jeffrey R. Moffitt, Siyuan Wang