Patents Assigned to College
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Patent number: 11104937Abstract: The embodiments disclosed herein utilized RNA targeting effectors to provide a robust CRISPR-based diagnostic with attomolar sensitivity. Embodiments disclosed herein can detect broth DNA and RNA with comparable levels of sensitivity and can differentiate targets from non-targets based on single base pair differences. Moreover, the embodiments disclosed herein can be prepared in freeze-dried format for convenient distribution and point-of-care (POC) applications. Such embodiments are useful in multiple scenarios in human health including, for example, viral detection, bacterial strain typing, sensitive genotyping, and detection of disease-associated cell free DNA.Type: GrantFiled: March 15, 2018Date of Patent: August 31, 2021Assignees: The Broad Institute, Inc., Massachusetts Institute of Technology, President and Fellows of Harvard College, The General Hospital CorporationInventors: Omar Abudayyeh, James Joseph Collins, Jonathan Gootenberg, Feng Zhang, Eric S. Lander, Roby Bhattacharyya, Deborah Hung
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Patent number: 11106186Abstract: Aspects of the present disclosure include anonymous, asynchronous, and randomized control schemes for distributed energy resources (DERs). Such control schemes may include packetized energy management (PEM) control schemes for managing DERs that may provide near-optimal tracking performance under imperfect information and consumer quality of service (QoS) constraints.Type: GrantFiled: May 23, 2019Date of Patent: August 31, 2021Assignee: University of Vermont and State Agricultural CollegeInventors: Jeffrey Frolik, Paul Hines, Mads Almassalkhi
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Patent number: 11104892Abstract: Embodied herein are engineered fusion proteins that bind and target nociceptor neurons, compositions comprising these engineered fusion proteins, and methods for treatment of pain using these engineered fusion proteins or compositions containing the engineered fusion proteins. The engineered fusion proteins contain domains derived from protein toxins such as the anthrax toxin, clostridial botulinum family of toxins, disulphide-containing toxins, and AB component type toxins.Type: GrantFiled: May 27, 2020Date of Patent: August 31, 2021Assignees: President and Fellows of Harvard College, Massachusetts Institute of TechnologyInventors: R. John Collier, Isaac Chiu, Bradley L. Pentelute
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Patent number: 11104926Abstract: Provided are N,N?-diacyl rhodamine compounds, which may be converted to rhodamine by porcine liver esterase (PLE) to produce a fluorescence signal. These compounds may be used, for example, as substrates in enzymatic assays or as labels in cellular imaging.Type: GrantFiled: March 26, 2019Date of Patent: August 31, 2021Assignees: Vanderbilt University, Meharry Medical CollegeInventors: Gary A. Sulikowski, Kristopher K. Abney, Susan J. Ramos-Hunter, Ian M. Romaine, Charles David Weaver
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Patent number: 11104883Abstract: Disclosed herein are methods, compositions, kits, and agents useful for inducing ? cell maturation, and isolated populations of SC-? cells for use in various applications, such as cell therapy.Type: GrantFiled: July 21, 2020Date of Patent: August 31, 2021Assignee: President and Fellows of Harvard CollegeInventors: Quinn P. Peterson, Felicia J. Pagliuca, Douglas A. Melton, Jeffrey R. Millman, Michael Saris Segel, Mads Gurtler
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Patent number: 11104967Abstract: Some aspects of the present disclosure provide methods for evolving recombinases to recognize target sequences that differ from the canonical recognition sequences. Some aspects of this disclosure provide evolved recombinases, e.g., recombinases that bind and recombine naturally-occurring target sequences, such as, e.g., target sequences within the human Rosa26 locus. Methods for using such recombinases for genetically engineering nucleic acid molecules in vitro and in vivo are also provided. Some aspects of this disclosure also provide libraries and screening methods for assessing the target site preferences of recombinases, as well as methods for selecting recombinases that bind and recombine a non-canonical target sequence with high specificity.Type: GrantFiled: July 24, 2019Date of Patent: August 31, 2021Assignee: President and Fellows of Harvard CollegeInventors: David R. Liu, David B. Thompson, Jeffrey L. Bessen
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Patent number: 11103686Abstract: Systems and methods for creating microneedle arrays capable of delivering a suitable drug dosages to subjects are provided. In one aspect, a method comprises creating at least one forming mold using laser ablation in a cross-over line pattern. The method further comprises casting a first material onto the at least one forming mold to create at least one microneedle mold. The method further comprises casting a second material onto the at least one microneedle mold to create at least one hollow microneedle.Type: GrantFiled: October 16, 2018Date of Patent: August 31, 2021Assignee: Trustees of Tufts CollegeInventors: Hojatollah Rezaei Nejad, Aydin Sadeqi, Sameer Sonkusale
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Publication number: 20210263027Abstract: Articles and methods involving fluidic devices are generally provided. In some embodiments, a fluidic device comprises a first layer comprising a central region in fluidic communication with an environment external to the fluidic device. The first layer may also comprise a first channel and a second channel in fluidic communication with the central region and extending radially outwards therefrom. The first and second channels may comprises first and second sample regions from which first and second samples can be removed from the fluidic device. In some embodiments, a fluidic device comprises a first layer and a second, filtration layer configured to separate blood cells from plasma positioned between the environment external to the fluidic device and the first layer.Type: ApplicationFiled: June 19, 2019Publication date: August 26, 2021Applicant: Trustees of Tufts CollegeInventors: Charles R. Mace, Jessica C. Brooks, Syrena C. Fernandes, Keith Baillargeon
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Publication number: 20210262970Abstract: In some embodiments, the present disclosure pertains to methods of detecting an analyte in a sample by associating the sample with an electrode that includes a metal-organic framework. After association, the redox properties of the electrode are evaluated. Thereafter, the presence or absence of the analyte in the sample is detected by correlating the redox properties of the electrode to the presence or absence of the analyte. In some embodiments, the present disclosure pertains to electrodes that include a metal-organic framework and an electrode surface. In particular embodiments of the present disclosure, the metal-organic framework is associated with the electrode surface. Additional embodiments of the present disclosure pertain to methods of making the electrodes of the present disclosure by associating a metal-organic framework with an electrode surface. In some embodiments, the methods of the present disclosure also include a step of mixing the metal-organic framework with a polymer.Type: ApplicationFiled: June 21, 2019Publication date: August 26, 2021Applicant: Trustees of Dartmouth CollegeInventors: Katherine A. Mirica, Lukasz K. Mendecki, Michael Ko, Zheng Meng, Robert M. Stolz, Aileen Eagleton
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Publication number: 20210261566Abstract: The present invention provides novel Compound (1) having tumor vascular remodeling effect and/or anti-CAF (Cancer Associated Fibroblasts) activity, or a pharmaceutically acceptable salt thereof, optionally in a pharmaceutically acceptable carrier, and medical uses thereof.Type: ApplicationFiled: February 4, 2021Publication date: August 26, 2021Applicants: President and Fellows of Harvard College, Eisai R&D Management Co., LTD.Inventors: Yoshito Kishi, Kazunobu Kira, Ken Ito
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Publication number: 20210262011Abstract: Methods of making a three-dimensional matrix of nucleic acids within a cell is provided.Type: ApplicationFiled: April 23, 2021Publication date: August 26, 2021Applicants: President and Fellows of Harvard College, President and Fellows of Harvard CollegeInventors: George M. Church, Jehyuk Lee, Daniel Levner, Michael Super
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Publication number: 20210261930Abstract: Methods, systems, compositions and strategies for the delivery of WW domain-containing fusion proteins into cells in vivo, ex vivo, or in vitro via ARMMs are provided. Methods, systems, compositions and strategies for the delivery of Cas9 proteins and/or Cas9 variants into cells in vivo, ex vivo, or in vitro via fusion to ARMM associated proteins (e.g., ARRDC1 or TSG101) are also provided.Type: ApplicationFiled: February 5, 2021Publication date: August 26, 2021Applicants: President and Fellows of Harvard College, The Board of Trustees of the Leland Stanford Junior UniversityInventors: Quan Lu, Qiyu Wang, Stanley N. Cohen
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Publication number: 20210261938Abstract: Some aspects of this disclosure relate to strategies, systems, methods, compositions, and kits that are useful for production (e.g., evolution) of cytidine deaminase protein variants that are characterized by increased soluble expression and/or stability relative to the wild-type cytidine deaminase protein from which they are evolved. In some embodiments, evolved cytidine deaminase variants described by the disclosure are useful for incorporation into targeted nucleic acid editing proteins, for example in fusion proteins with a Cas9 domain or variant thereof.Type: ApplicationFiled: June 14, 2019Publication date: August 26, 2021Applicant: President and Fellows of Flarvard CollegeInventors: David R. Liu, Tina Wang
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Patent number: 11097090Abstract: Methods and apparatuses relate to an implantable device for providing contractile assistance to an organ. The device may include an actuator and anchors located on either side of the actuator. The anchors engage with oppositely positioned tissue walls of an organ chamber, and provide contractile assistance to the organ, repeatedly, at appropriate times. For example, the device may be implanted within the right ventricle, anchored to the right ventricular free wall and the ventricular septum. The device may function to bring the opposing walls of the ventricle toward one another, synchronized with the pacing of the heart, resulting in an improved ejection fraction of blood from the chamber. In some embodiments, the actuator includes a bladder that is configured to contract upon receiving an inflow of pressurized fluid therein. When the fluid exits therefrom, the bladder relaxes back to an initial, extended state.Type: GrantFiled: March 28, 2018Date of Patent: August 24, 2021Assignees: President and Fellows of Harvard College, Children's Medical Center CorporationInventors: Nikolay V. Vasilyev, Pedro J. del Nido, Tonatiuh M. Lievano Beltran, Erik A. Kraus, Nikhil Mehandru, Evelyn J. Park, Conor J. Walsh, Isaac Wamala, Markus Horvath
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Patent number: 11099210Abstract: A method of carrying out sub-resonant tapping in an atomic force microscope includes causing a probe that is disposed above a sample to be translated in a direction parallel to a horizontal plane defined by the sample and to oscillate in a vertical direction that is perpendicular to the horizontal plane about an equilibrium line that is separated from the horizontal plane by a vertical offset. As a result, the probe repeatedly taps a surface of the sample. Each tap begins with a first contact of the probe on the surface followed by a progressive increase in force exerted by the sample on the probe until a peak force is attained. The vertical offset is controlled by relying at least in part on a feature other than the peak force as a basis for controlling the vertical offset.Type: GrantFiled: January 30, 2018Date of Patent: August 24, 2021Assignee: Trustees of Tufts CollegeInventors: Piers Echols-Jones, William C. Messner, Igor Sokolov
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Phenylsulfonamido-benzofuran derivatives and uses thereof in the treatment of proliferative diseases
Patent number: 11098021Abstract: Described herein are phenylsulfonamido-benzofuran derivatives, and pharmaceutically acceptable salts thereof. Also provided are pharmaceutical compositions, methods, uses, and kits involving compounds of Formulae (I), (II), (III), (IV), (V), or (VI) for treating and/or preventing proliferative diseases (e.g. cancers, inflammatory diseases, and autoimmune diseases) in a subject. The compounds and pharmaceutical compositions as described herein inhibit at least one protein of the BCL-2 family in a biological sample or subject to treat and/or prevent a proliferative disease. In certain embodiments, compounds described herein are selective inhibitors of MCL-1, a BCL-2 family member protein.Type: GrantFiled: August 12, 2016Date of Patent: August 24, 2021Assignees: Memorial Sloan-Kettering Cancer Center, Albert Einstein College of Medicine, Inc.Inventors: Emily H. Cheng, Paul Jeng, Ouathek Ouerfelli, James Hsieh, Guangli Yang, Evripidis Gavathiotis -
Patent number: 11096924Abstract: Disclosed are combination therapies including administration of I-DASH inhibitors and PGE2 antagonists, and the use of such therapies in the treatment of cell proliferative diseases.Type: GrantFiled: September 7, 2017Date of Patent: August 24, 2021Assignee: Trustees of Tufts CollegeInventors: William W. Bachovchin, Hung-sen Lai, Wengen Wu
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Patent number: 11100893Abstract: The present invention discloses an eye protection method and system for an intelligent terminal, which uses a light sensor to acquire ambient light, uses a distance sensor to acquire a distance between a user's eyes and a screen of the intelligent terminal, uses a camera to identify a user identity, and uses eye protection software to monitor display content and perform data analysis, thereby achieving automatic adjustment of screen brightness, automatic adjustment of screen color temperature, adjustment of display mode, automatic restriction of use time, switching to basic communication function, and so on. The present invention intelligently adjusts the eye protection threshold, improves the practicability and effectiveness of the eye protection method, and improves the experience effect of the user's eye protection function.Type: GrantFiled: January 3, 2020Date of Patent: August 24, 2021Assignee: Chinese Academy of Medical Sciences & Peking Union Medical College, Institute of Biomedical EngineeringInventors: Yingxin Li, He Huang, Huijuan Yin, Xiaoxi Dong
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Patent number: 11101915Abstract: The subject method for delivering power to a moving target wirelessly via electromagnetic time reversal can find applications in wireless electrical transmission to portable devices, wireless heating of portable devices, novel wirelessly powered accelerometers, hyperthermic treatment of cancers, and many other applications. The subject non-linear time reversed electromagnetic waves based wireless power transmission (WPT) system targets either a single linear or non-linear object where a selective targeting between two diodes has been demonstrated simultaneously with different degrees of non-linearity in a three-dimensional ray-chaotic billiard model. A dual-purpose rectenna with harmonic generation for wireless power transfer by non-linear time-reversal has been designed for the subject system using the Schottky diode.Type: GrantFiled: April 25, 2017Date of Patent: August 24, 2021Assignee: University of Maryland, College ParkInventors: Steven Mark Anlage, Frank Cangialosi, Tyler Grover, Andrew Simon, Scott Roman, Liangcheng Tao
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Patent number: 11098303Abstract: The present invention generally relates to systems and methods for imaging or determining nucleic acids, for instance, within cells. In some embodiments, the transcriptome of a cell may be determined. Certain embodiments are directed to determining nucleic acids, such as mRNA, within cells at relatively high resolutions. In some embodiments, a plurality of nucleic acid probes may be applied to a sample, and their binding within the sample determined, e.g., using fluorescence, to determine locations of the nucleic acid probes within the sample. In some embodiments, codewords may be based on the binding of the plurality of nucleic acid probes, and in some cases, the codewords may define an error-correcting code to reduce or prevent misidentification of the nucleic acids. In certain cases, a relatively large number of different targets may be identified using a relatively small number of labels, e.g., by using various combinatorial approaches.Type: GrantFiled: July 29, 2015Date of Patent: August 24, 2021Assignee: President and Fellows of Harvard CollegeInventors: Xiaowei Zhuang, Kok-Hao Chen, Alistair Boettiger, Jeffrey R. Moffitt, Siyuan Wang