Patents Assigned to College
  • Patent number: 12054508
    Abstract: In one aspect, the disclosure relates to a facile strategy to introduce electron-deficient aryl sulfate diesters to silylated hydroxyl groups of carbohydrates and amino acids, among other substrates, wherein selective hydrolysis and the removal of an electron-deficient aromatic group allows for the efficient generation of sulfated carbohydrates, peptides, and other compounds. The incorporation of electron-deficient aryl sulfate diesters in the early stage of the synthesis of glycans, peptides, and the like, disclosed herein avoids time-consuming protecting group manipulations, simplifies the purification of sulfated products, and improves the overall yield and efficiency. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
    Type: Grant
    Filed: July 12, 2022
    Date of Patent: August 6, 2024
    Assignee: The Trustees of Boston College
    Inventors: Jia Niu, Chao Liu, Cangjie Yang
  • Patent number: 12053460
    Abstract: The disclosure provides compounds that inhibit the invasion of host cells by intracellular parasites. These find use, for example, in treating and preventing periodontitis or a periodontitis-related condition or symptom.
    Type: Grant
    Filed: August 16, 2021
    Date of Patent: August 6, 2024
    Assignees: Meharry Medical College, Duke University
    Inventors: Hua Xie, Chin-Ho Chen
  • Patent number: 12054724
    Abstract: Aspects of the disclosure relate to compositions and methods useful for treating hereditary hearing loss, for example, Usher syndrome type 3A or nonsyndromic hearing loss and deafness (DFNB1). In some embodiments, the disclosure provides isolated nucleic acids, vectors, and rAAV.9.PHP.B comprising a transgene encoding a Clarin-1 or a GJB2, and methods of treating hearing loss using the same.
    Type: Grant
    Filed: April 10, 2019
    Date of Patent: August 6, 2024
    Assignees: President and Fellows of Harvard College, The General Hospital Corporation
    Inventors: Casey A. Maguire, David P. Corey, Bence Gyorgy
  • Patent number: 12057556
    Abstract: The present invention is directed to aqueous and hybrid aqueous electrolytes that comprise a lithium salt. The present invention is also directed to methods of making the electrolytes and methods of using the electrolytes in batteries and other electrochemical technologies.
    Type: Grant
    Filed: June 14, 2021
    Date of Patent: August 6, 2024
    Assignees: University of Maryland, College Park, The United States of America as Represented by the Secretary of the Army
    Inventors: Kang Xu, Arthur Von Wald Cresce, Oleg A. Borodin, Chunsheng Wang, Liumin Suo
  • Patent number: 12054745
    Abstract: Disclosed herein are methods, compositions, kits, and agents useful for inducing ? cell maturation, and isolated populations of SC-? cells for use in various applications, such as cell therapy.
    Type: Grant
    Filed: February 11, 2022
    Date of Patent: August 6, 2024
    Assignee: President and Fellows of Harvard College
    Inventors: Quinn P. Peterson, Felicia J. Pagliuca, Douglas A. Melton, Jeffrey Robert Millman, Michael Saris Segel, Mads Gurtler
  • Patent number: 12053886
    Abstract: A control system for a robotic device comprising a task embedding network to receive one or more demonstrations of a task and to generate a task embedding. The task embedding comprises a representation of the task, and each demonstration comprises one or more observations of a performance of the task. The control system includes a control network to receive the task embedding from the task embedding network and to apply a policy to map a plurality of successive observations of the robotic device to respective control instructions for the robotic device. The policy applied by the control network is modulated across the plurality of successive observations of the robotic device using the task embedding from the task embedding network.
    Type: Grant
    Filed: March 19, 2021
    Date of Patent: August 6, 2024
    Assignee: Imperial College Innovations Limited
    Inventors: Stephen Lloyd James, Michael Bloesch, Andrew Davison
  • Patent number: 12053501
    Abstract: The present disclosure relates to, among other things, compositions and methods for treating an inflammatory condition including, but not limited to, ocular inflammation, dry eye disease, and ocular neuropathic pain. One aspect of the present disclosure relates to a composition comprising (a) chemerin or a fragment or analog thereof and (b) a lipid entity linked to the chemerin or fragment or analog thereof.
    Type: Grant
    Filed: November 8, 2021
    Date of Patent: August 6, 2024
    Assignees: Tufts Medical Center, Trustees of Tufts College, On Target Therapeutics LLC
    Inventors: Charles Cohen, Krishna Kumar, Alan S. Kopin, Benjamin N. Harwood, Venkata S. Raman, Pedram Hamrah
  • Patent number: 12053561
    Abstract: The present disclosure provides click-crosslinked hydrogels and methods of use.
    Type: Grant
    Filed: September 15, 2020
    Date of Patent: August 6, 2024
    Assignee: President and Fellows of Harvard College
    Inventors: Rajiv Desai, Neel Satish Joshi, David J. Mooney, Sandeep T. Koshy, Alexander Stafford
  • Patent number: 12053513
    Abstract: The present disclosure relates to a new anti-cancer peptide; a vector encoding same; a pharmaceutical composition or immunogenic agent or bispecific or vaccine comprising said anti-cancer peptide; use of said anti-cancer peptide, vector, pharmaceutical composition, immunogenic agent, bispecific or vaccine to treat cancer; a method of treating cancer using said anti-cancer peptide, vector, pharmaceutical composition, immunogenic agent, bispecific or vaccine; and a combination therapeutic for the treatment of cancer comprising said anti-cancer peptide, vector, pharmaceutical composition, immunogenic agent, bispecific or vaccine.
    Type: Grant
    Filed: December 11, 2020
    Date of Patent: August 6, 2024
    Assignee: University College Cardiff Consultants Ltd.
    Inventors: Andrew Sewell, Garry Dolton
  • Publication number: 20240254437
    Abstract: Provided herein are pluripotent stem cells comprising particular combinations of transcription factor for the production of oligodendrocyte progenitor cells (OPCs). Also provided herein are methods of producing the pluripotent stem cells and methods of using the pluripotent stem cells to produce (OPCs) and oligodendrocytes.
    Type: Application
    Filed: February 9, 2024
    Publication date: August 1, 2024
    Applicant: President and Fellows of Harvard College
    Inventors: Parastoo Khoshakhlagh, Hon Man Alex Ng, George M. Church
  • Publication number: 20240255461
    Abstract: Disclosed herein are an apparatus for electrically assessing and/or manipulating cells. One aspect is directed to electrically mapping cells on the surface of the semiconductor substrate via cross-electrode impedance measurements. Further according to some aspects, the electrode array allows for spatially addressable electrical stimulation and/or recording of electrical signals in real-time using the CMOS circuitry. Some of these aspects are directed to using an electrode array to perform cell patterning through electrochemical gas generation, and extracellular electrochemical mapping.
    Type: Application
    Filed: August 31, 2023
    Publication date: August 1, 2024
    Applicant: President and Fellows of Harvard College
    Inventors: Hongkun Park, Jeffrey T. Abbott, Wenxuan Wu, Tianyang Ye, Han Sae Jung, Donhee Ham
  • Patent number: 12049653
    Abstract: Unglycosylated lysostaphin variant protein, nucleic acid molecule, vector and host cell, as well as a method for production of unglycosylated lysostaphin variant protein in a yeast expression system are provided. The proteins are produced in a Pichia pastoris expression system and have been shown to have activity equivalent to wild-type lysostaphin. The lysostaphin variant proteins can be used as therapeutic proteins for treatment of diseases such as Staphylococcus aureus infection.
    Type: Grant
    Filed: September 21, 2021
    Date of Patent: July 30, 2024
    Assignee: Trustees of Dartmouth College
    Inventors: Karl E. Griswold, Hongliang Zhao
  • Patent number: 12048716
    Abstract: Embodiments of the disclosure include methods and compositions for producing NKT cells effective for immunotherapy and also methods and compositions for providing an effective amount of NKT cells to an individual in need of immunotherapy. In specific embodiments, the NKT cells are CD62L+ and have been exposed to one or more costimulatory agents to maintain CD62L expression. The NKT cells may be modified to incorporate a chimeric antigen receptor, in some cases.
    Type: Grant
    Filed: April 21, 2016
    Date of Patent: July 30, 2024
    Assignee: Baylor College of Medicine
    Inventors: Leonid S. Metelitsa, Amy N. Courtney, Gengwen Tian
  • Patent number: 12048721
    Abstract: Methods and compositions are provided for treating weight related conditions and metabolic disorders by altering microbiota in a subject. One aspect provides methods and compositions to alter microbiota in a subject by administering to the subject a composition that includes a substantially purified microbiota from phyla such as Bacteroidetes, Proteobacteria, Firmicutes and Verrucomicrobia or orders such as Bacteroidales, Verrucomicrobiales, Clostridiales and Enterobacteriales or genera such as Alistipes, Clostridium, Escherichia, and Akkermansia. Another aspect includes a pharmaceutical composition for altering microbiota that includes a therapeutically effective amount of substantially purified microbiota and a pharmaceutically acceptable carrier. Yet another aspect includes methods for treating a disorder, such as obesity, in a subject in need of such treatment by changing relative abundance of microbiota in a gastrointestinal tract of the subject without or in addition to a surgical procedure.
    Type: Grant
    Filed: March 26, 2020
    Date of Patent: July 30, 2024
    Assignees: The General Hospital Corporation, Presidents and Fellows of Harvard College, Johnson & Johnson Consumer Inc.
    Inventors: Lee M. Kaplan, Alice P. Liou, Peter J. Turnbaugh, Jason L. Harris
  • Patent number: 12049646
    Abstract: Disclosed herein are methods, compositions, kits, and agents useful for inducing ? cell maturation, and isolated populations of SC-? cells for use in various applications, such as cell therapy.
    Type: Grant
    Filed: December 22, 2023
    Date of Patent: July 30, 2024
    Assignee: President and Fellows of Harvard College
    Inventors: Quinn P. Peterson, Felicia J. Pagliuca, Douglas A. Melton, Jeffrey Robert Millman, Michael Saris Segel, Mads Gurtler
  • Patent number: 12049482
    Abstract: The present disclosure relates to therapeutic methods and clinically useful molecular switches, for which activity or degradation of a switch-presenting polypeptide can be precisely induced via administration or withdrawal of an FDA-approved drug. Certain aspects of the disclosure relate to an engineered drug-inducible heterodimeric system including a first polypeptide presenting a CRBN polypeptide disrupted for or lacking a DDB 1-interacting domain and a second polypeptide presenting a CRBN polypeptide substrate, where binding between the CRBN polypeptide and the CRBN polypeptide substrate are inducible via administration of an CFDA-approved thalidomide analog immunomodulatory drug (IMiD). Another aspect of the disclosure relates to a chimeric antigen receptor (CAR) that presents a minimal fragment of the CRBN polypeptide substrate IKZF3 capable of triggering proteasomal degradation of CAR upon administration of an FDA-approved IMiD.
    Type: Grant
    Filed: October 30, 2018
    Date of Patent: July 30, 2024
    Assignees: The Brigham and Women's Hospital, Inc., The General Hospital Corporation, President and Fellows of Harvard College
    Inventors: Max Jan, Quinlan L. Sievers, Benjamin Ebert, Marcela Maus
  • Patent number: 12051520
    Abstract: Systems and methods relate to arranging atoms into 1D and/or 2D arrays; exciting the atoms into Rydberg states and evolving the array of atoms, for example, using laser manipulation techniques and high-fidelity laser systems described herein; and observing the resulting final state. In addition, refinements can be made, such as providing high fidelity and coherent control of the assembled array of atoms. Exemplary problems can be solved using the systems and methods for arrangement and control of atoms.
    Type: Grant
    Filed: June 5, 2023
    Date of Patent: July 30, 2024
    Assignees: President and Fellows of Harvard College, California Institute of Technology, Massachusetts Institute of Technology
    Inventors: Alexander Keesling Contreras, Hannes Bernien, Sylvain Schwartz, Harry Jay Levine, Ahmed Omran, Mikhail D. Lukin, Vladan Vuletic, Manuel Endres, Markus Greiner, Hannes Pichler, Leo Zhou, Shengtao Wang, Soonwon Choi, Donggyu Kim, Alexander S. Zibrov
  • Patent number: 12048792
    Abstract: The present invention has to do with a method and system for preformed peritoneal dialysis (PD) catheter weighted anchors. The peritoneal dialysis catheter weighted anchors can be inserted and retrieved using standard techniques and available insertion/retrieval systems. The peritoneal dialysis catheter weighted anchors can be attached and secured to all types of PD catheters as an ancillary anchor device.
    Type: Grant
    Filed: December 20, 2019
    Date of Patent: July 30, 2024
    Assignee: The University of Vermont and State Agricultural College
    Inventor: Christopher S. Morris
  • Publication number: 20240247252
    Abstract: This patent document provides novel compounds as warheads for therapeutic or diagnostic agents. Advantages of the agents modified with the warheads include low off-target conjugation and minimized immunogenicity due to the reversible covalent bonding between the warheads and the targets.
    Type: Application
    Filed: January 5, 2024
    Publication date: July 25, 2024
    Applicant: The Trustees of Boston College
    Inventor: Jianmin Gao
  • Publication number: 20240246284
    Abstract: A filamentary structure extruded from a nozzle during 3D printing comprises a continuous filament including filler particles dispersed therein. At least some fraction of the filler particles in the continuous filament comprise high aspect ratio particles having a predetermined orientation with respect to a longitudinal axis of the continuous filament. The high aspect ratio particles may be at least partially aligned along the longitudinal axis of the continuous filament. In some embodiments, the high aspect ratio particles may be highly aligned along the longitudinal axis. Also or alternatively, at least some fraction of the high aspect ratio particles may have a helical orientation comprising a circumferential component and a longitudinal component, where the circumferential component is imparted by rotation of a deposition nozzle and the longitudinal component is imparted by translation of the deposition nozzle.
    Type: Application
    Filed: September 6, 2023
    Publication date: July 25, 2024
    Applicant: President and Fellows of Harvard College
    Inventors: Jennifer A. Lewis, Brett G. Compton, Jordan R. Raney, Thomas J. Ober