Patents Assigned to College
  • MAGNETIC NANOPARTICLES, COMPOSITES, SUSPENSIONS AND COLLOIDS WITH HIGH SPECIFIC ABSORPTION RATE (SAR)
    Publication number: 20150306246
    Abstract: Iron oxide nanoparticles and nanocomposites with organic molecules embedded in their structure, having exceptionally high SAR values, are provided for biological, medical (for example, drug delivery, hyperthermia, etc.) and other uses.
    Type: Application
    Filed: December 6, 2013
    Publication date: October 29, 2015
    Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE
    Inventors: Ian Baker, Katsiaryna Kekalo
  • MEMBRANE-BASED FLUID-FLOW CONTROL DEVICES
    Publication number: 20150306596
    Abstract: Described herein are fluid-flow control devices for transferring a fluid from a place to another and/or controlling a fluid flow. In some embodiments, fluid-flow control devices described herein can be used as pumping devices to transfer a fluid by peristaltic motion and/or as valve devices to control fluid flow for various applications, e.g., in a microfluidic platform.
    Type: Application
    Filed: December 10, 2013
    Publication date: October 29, 2015
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Guy THOMPSON, Daniel LEVNER, Christopher David HINOJOSA
  • CLASS- AND ISOFORM-SPECIFIC HDAC INHIBITORS AND USES THEREOF
    Publication number: 20150307444
    Abstract: HDAC inhibitors of the general formula (I) and (II) and pharmaceutically acceptable salts thereof, as described herein, are useful as inhibitors of histone deacetylases or other deacetylases, and thus are useful for the treatment of various diseases and disorders associated with acetylase/deacetylase activity as described herein (e.g., cancer). In certain embodiments, the compounds of the invention selectively target either a class or isoform of the HDAC family. Another aspect of the invention provides an assay for determining the inhibitory effect of a test compound on an HDAC protein comprising: incubating the HDAC protein with a substrate of general formula (IIIc) in the presence of a test compound; and determining the activity of the HDAC protein.
    Type: Application
    Filed: May 6, 2014
    Publication date: October 29, 2015
    Applicants: President and Fellows of Harvard College, Dana-Farber Cancer Institute, Inc.
    Inventors: Ralph Mazitschek, James E. Bradner
  • THERAPY FOR RADIATION-INDUCED LUNG INJURY
    Publication number: 20150306177
    Abstract: Methods are disclosed for therapy of radiation-induced lung injury and other lung diseases using R-spondin1.
    Type: Application
    Filed: March 24, 2015
    Publication date: October 29, 2015
    Applicant: ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY
    Inventors: Chandan Guha, Subhrajit Saha
  • Compositions and Methods for the Treatment of Metabolic and Related Disorders
    Publication number: 20150307501
    Abstract: The present invention relates to the compound for treatment and/or prevention of one or more metabolic disorders utilizes an A-B-C tripartite structure, wherein A, B, and C are identical or non-identical structures, for example, but not limited to, heterocyclic, phenyl or benzyl ring structures with or without substitutions and are described in detail herein. Also provided are methods for the treatment and/or prevention of one or more metabolic disorders, for example, obesity or diabetes, utilizing fatostatin A and/or a derivative and/or analog thereof and/or the A-B-C tripartite compounds.
    Type: Application
    Filed: July 15, 2015
    Publication date: October 29, 2015
    Applicant: BAYLOR COLLEGE OF MEDICINE
    Inventors: Motonari Uesugi, Salih J. Wakil, Lutfi Abu-Elheiga, Mizuki Watanabe
  • Bioactive glass composition
    Patent number: 9168272
    Abstract: A bioactive glass composition comprising one or more glasses comprising Si02, P205 and a fluoride, the Si02 content being less than 40 mole %, the P205 content being at least 4 mole %, and the fluoride content being greater than 1 mole %. The bioactive glass or glass-ceramic can be used in a number of medical applications, including dental applications such as toothpaste.
    Type: Grant
    Filed: June 24, 2011
    Date of Patent: October 27, 2015
    Assignee: Queen Mary and Westfield College
    Inventors: Robert Hill, Delia Brauer, David G. Gillam, Natalia Karpukhina, Andrew Bushby, Mohammad Mneimne
  • Thiol Acrylate Nanocomposite Foams
    Publication number: 20150299412
    Abstract: Thiol-acrylate copolymers are disclosed that are useful, for example, as injectable biomaterials to provide both mechanical support and biological cues to stimulate bone regrowth. Composites can be formed, for example incorporating hydroxyapatite crystal inclusions into the copolymer. In one embodiment, the composite is gas-foamed with a blowing agent during or before cure to form a porous, interconnected scaffold. The synthesis employs an amine-catalyzed Michael addition co-polymerization of a poly-thiol with a poly-acrylate. The catalyst is an in situ catalyst, such as a tertiary amine moiety that is covalently bonded to one of the reactants, preferably to the poly-acrylate. The materials can rapidly co-polymerize in vivo or in vitro via catalysis by the “attached” in situ tertiary amine groups.
    Type: Application
    Filed: October 31, 2013
    Publication date: October 22, 2015
    Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Daniel HAYES, John Pojman
  • Artemisinin And Its Derivatives For Use In The Treatment Of Trauma Haemorrhage And Associated Conditions
    Publication number: 20150297558
    Abstract: The present invention relates to the treatment of trauma haemorrhage or trauma haemorrhage-induced organ injury and associated disorders (in particular stoke, burns and brain injury) using the anti-malarial compound artemisinin and its derivatives. The present invention also relates to the treatment of myocardial infarction and coronary heart disease (and associated disorders) using the anti-malarial compound artemisinin and its derivatives. The present invention also relates to the use of artemisinin and its derivatives in coronary artery bypass surgery, heart transplantation, and diseases associated with ischaemia-reperfusion.
    Type: Application
    Filed: June 8, 2012
    Publication date: October 22, 2015
    Applicant: Queen Mary & Westfield College, University of London
    Inventor: Christoph Thiemermann
  • SYSTEMS AND METHODS FOR DROPLET PRODUCTION AND MANIPULATION USING ACOUSTIC WAVES
    Publication number: 20150298157
    Abstract: Acoustic waves, including surface acoustic waves, are useful to control fluids. In one aspect, acoustic waves may be applied to a fluid flowing in a channel to control or alter its flow characteristics, e.g., its flow rate or direction. Acoustic waves are typically applied using electrically-controlled acoustic wave generators, and thus, the flow of fluid can be controlled to a surprisingly high degree. If the fluid is caused to form a series of droplets, then acoustic waves may be used to control the volume of fluid in each droplet, to alter the rate droplets are formed, or the like. Acoustic waves may be used to deflect the flow of fluid in a channel, and in some cases, to cause fluid to flow to different locations.
    Type: Application
    Filed: October 24, 2013
    Publication date: October 22, 2015
    Applicant: President and Fellows of Harvard College
    Inventors: David A. Weitz, Thomas Franke, Lothar Schmid
  • ENDOSCOPE PROPULSION
    Publication number: 20150297060
    Abstract: The present invention provides a system and method for active propulsion of devices, such as endoscopes, along cavities, such as body lumens. The propulsion system can be attached to a commercially available endoscope, or be provide affixed together, and moves the endoscope in a lumen by pulling it forward. The present invention further provides a method of diagnosing diseases and disorders, and treatment of diseases and disorders, using a device according to the invention.
    Type: Application
    Filed: April 22, 2015
    Publication date: October 22, 2015
    Applicant: Edward Via College of Osteopathic Medicine
    Inventor: M. Jonathan BERN
  • Nano-sized Bagasse Fiber
    Publication number: 20150299954
    Abstract: A new composition of nanosized bagasse fibers has been made by a method which reduces the sugarcane bagasse fibers to nano-sized particles while retaining the natural components of the bagasse. The resulting bagasse particles were shown to be effective as a nutritional supplement in a mouse model to aid in glucose control and body weight. Using the bagasse nanofibers, the addition of 5 to 10% fiber did not change the color or texture of food products. Moreover, the bagasse powder has a natural color and absorbs color evenly so that it could be used as a natural foundation material for cosmetic products.
    Type: Application
    Filed: June 30, 2015
    Publication date: October 22, 2015
    Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Kun Lian, William T. Cefalu, Zhong Q. Wang
  • AMPLIFIED DETECTOR FORMED BY LOW TEMPERATURE DIRECT WAFER BONDING
    Publication number: 20150303345
    Abstract: In one embodiment the invention relates to a photodetector device sensitive for wavelengths comprising a doped Ge absorbing material bonded to a substrate material locally of opposite doping polarity and an interface layer formed between the Ge absorbing material and the substrate material to form a p-n junction. In one embodiment the bonded material comprises a p-doped Ge wafer and n-doped Si or So I wafer and obtained from a low-temperature heat treatment after bonding. The invention also discloses a process for making a photodetector.
    Type: Application
    Filed: November 25, 2013
    Publication date: October 22, 2015
    Applicant: University College Cork-National University of Ireland, Cork
    Inventors: Farzan Gity, Brian Corbett, Alan Morrison, John Hayes
  • TRIOXACARCINS, TRIOXACARCIN-ANTIBODY CONJUGATES, AND USES THEREOF
    Publication number: 20150297747
    Abstract: Provided herein are trioxacarcin-antibody drug conjugates of Formula (A): and pharmaceutically acceptable salts thereof, comprising at least one instance of the group -L1-(A-L2)a-B attached thereto, wherein a is an integer between 1 and 10, inclusive, L1 is absent or is a linking group, A is a moiety formed from the reaction of two complimentary groups (X and Y), L2 is absent or is another linking group, and B is an antibody or antibody fragment. Also provided are methods of preparing these antibody-drug conjugates, pharmaceutically acceptable compositions thereof, and methods of their use and treatment. Further provided are precursors to the trioxacarcin-antibody drug conjugates, novel trioxacarcins without an antibody conjugated thereto, pharmaceutical compositions thereof, and methods of their use and treatment.
    Type: Application
    Filed: November 26, 2013
    Publication date: October 22, 2015
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Andrew G Myers, Daniel J. Smaltz, Andreas Schumacher
  • APPARATUS AND METHOD FOR NANOCOMPOSITE SENSORS
    Publication number: 20150302949
    Abstract: A sensing material for use in a sensor is disclosed. Such a sensing material includes a polymer base and a piezoresistive nanocomposite embedded into the polymer base in a continuous pattern. The nanocomposite comprises a polymer matrix and a plurality of conductive nanofillers suspended in the matrix. The conductive nanofillers may be one or a combination of nanotubes, nanowires, particles and flakes. The density of the plurality of nanofillers is such that the nanocomposite exhibits conductivity suitable for electronic and sensor applications.
    Type: Application
    Filed: June 26, 2015
    Publication date: October 22, 2015
    Applicant: BOUARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
    Inventors: Jin-Woo Choi, Chao-Xuan LIU
  • THERAPEUTIC AND DIAGNOSTIC TARGET GENE IN ACUTE MYELOID LEUKEMIA
    Publication number: 20150299336
    Abstract: Methods are provided for treating a cancer in a subject comprising administering to the subject an agent which inhibits expression of an HLX gene in the subject, or an agent which inhibits activity of an expression product of the HLX gene, and also for diagnosing a subject as likely to develop a cancer comprising determining whether a stem cell obtained from the subject expresses a HLX gene at a level in excess of predetermined control level. Kits therefor are also provided.
    Type: Application
    Filed: March 26, 2015
    Publication date: October 22, 2015
    Applicant: Albert Einstein College of Medicine of Yeshiva University
    Inventor: Ulrich G. Steidl
  • CANCER-ASSOCIATED GERM-LINE AND SOMATIC MARKERS AND USES THEREOF
    Publication number: 20150299795
    Abstract: The invention provides methods and compositions for identifying subjects, including canine subjects, having an elevated risk of developing cancer or having an undiagnosed cancer. These subjects are identified based on the presence of germ-line allele(s) and markers and various somatic mutations.
    Type: Application
    Filed: May 30, 2013
    Publication date: October 22, 2015
    Applicants: The Broad Institute, Inc., Trustees of Tufts College, North Carolina State University, Regents of the University of Minnesota
    Inventors: Kerstin Lindblad-Toh, Noriko Tonomura, Evan Mauceli, Jaime Modiano, Matthew Breen
  • CELL BASED QUALITY CONTROL BIOASSAYS FOR NUTRICEUTICAL AND MEDICINAL PRODUCTS
    Publication number: 20150301023
    Abstract: A method for determining the translation initiation inhibitory potency of a composition having an unknown level of translation initiation inhibitory activity which comprises contacting an eI-F2?-WT cell with said composition for a time and at a temperature effective to inhibit proliferation of said cell, measuring the level of inhibition of proliferation of said eIF2?-WT cells induced by said sample and comparing the level of inhibition of proliferation induced by said sample with the level of inhibition of proliferation induced by a standard having a known amount of said activity, the amount of said translation initiation inhibitory activity in said sample being proportional to the level of inhibition of proliferation of said eIF2?-WT cell.
    Type: Application
    Filed: July 22, 2013
    Publication date: October 22, 2015
    Applicant: President and Fellows of Havard College
    Inventors: Jose A. Halperin, Michael Chorev, Huseyin Aktas
  • Sandwich Panel with a Ductile Hybrid Core Comprising Tubular Reinforcements
    Publication number: 20150300019
    Abstract: A hybrid core comprising a matrix and tubular structural reinforcements, such as a ductile matrix core reinforced with ductile hollow tubes, as well as panels which comprise such hybrid core. Embodiments of the invention manifest resistance to both interfacial debonding and ballistic penetration.
    Type: Application
    Filed: November 7, 2013
    Publication date: October 22, 2015
    Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Guoqiang Li, Gefu Ji
  • Agents That Modulate Immune Cell Activation and Methods of Use Thereof
    Publication number: 20150299322
    Abstract: The present invention relates to compositions and methods for the immunomodulation mediated by the interaction of PD-L2 and RGMb.
    Type: Application
    Filed: August 2, 2013
    Publication date: October 22, 2015
    Applicants: Dana-Farber Cancer Institute, Inc., Boston Children's Hospital, President and Fellows of Harvard College
    Inventors: Gordon J. Freeman, Arlene H. Sharpe, Yanping Xiao, Loise Francisco, Rosemarie Dekruyff, Dale Umetsu
  • Method for making polymer composites containing graphene sheets
    Patent number: 9162896
    Abstract: In one embodiment, a method for producing a graphene-containing composition is provided, the method comprising: (i) mixing a graphene oxide with a medium to form a mixture; and (ii) heating the mixture to a temperature above about 40° C., whereby a graphene-containing composition is formed from the mixture. Composites of polymers with disperse functionalized graphene sheets and the applications thereof are also described.
    Type: Grant
    Filed: May 28, 2010
    Date of Patent: October 20, 2015
    Assignee: College of William and Mary
    Inventors: David Kranbuehl, Sarah Cotts, Hannes C. Schniepp, Minzhen Cai, Arthur Jaeton Glover