Patents Assigned to College
  • P13K-MTORC1-S6K1 signaling pathway biomarkers predictive of anti-cancer responses
    Patent number: 11366100
    Abstract: The present invention is based, in part, on the identification of novel FI.3K-mTORCI-S6K 1 signaling pathway biomarkers predictive of responsiveness to anti-cancer therapies.
    Type: Grant
    Filed: February 12, 2015
    Date of Patent: June 21, 2022
    Assignees: Dana-Farber Cancer Institute, Inc., President and Fellows of Harvard College
    Inventors: Thomas M. Roberts, Haoxuan Tong, Jean Zhao, John Blenis
  • UNIVERSALLY FRIENDLY OBTURATOR (UFO) FOR BRACHYTHERAPY TREATMENT OF CERVICAL CANCER
    Publication number: 20220184417
    Abstract: The present invention provides a brachytherapy applicator device having: an elongate body defining a plurality of brachytherapy needle channels, each adapted and configured to receive a brachytherapy needle; a proximal end defining a plurality of proximal openings, each in communication with one of the plurality of brachytherapy needle channels; and a distal end defining a plurality of distal openings, each in communication with one of the plurality of brachytherapy needle channels, wherein at least some of the plurality of brachytherapy needle channels are curved away from a central axis of the elongate body at the distal end such that a brachytherapy needle inserted therethrough will engage with tissue lateral to a cross-sectional profile of the distal end of the elongate body.
    Type: Application
    Filed: December 14, 2021
    Publication date: June 16, 2022
    Applicants: Baylor College of Medicine, William Marsh Rice University
    Inventors: Alexander Hanania, Michelle S. Ludwig, Elisa Arango, Susannah Dittmar, Krithika Kumar, Lauren Payne, Sanika Rane, Andrea Samantha Gobin
  • Agents that modulate immune cell activation and methods of use thereof
    Patent number: 11359020
    Abstract: The present invention relates to compositions and methods for the immunomodulation mediated by the interaction of PD-L2 and RGMb.
    Type: Grant
    Filed: September 16, 2019
    Date of Patent: June 14, 2022
    Assignees: Dana-Farber Cancer Institute, Inc., President and Fellows of Harvard College, Children's Medical Center Corporation
    Inventors: Gordon J. Freeman, Arlene H. Sharpe, Yanping Xiao, Loise Francisco, Rosemarie Dekruyff, Dale Umetsu
  • Self-healing composite of thermoset polymer and programmed super contraction fibers
    Patent number: 11358901
    Abstract: A composition comprising thermoset polymer, shape memory polymer to facilitate macro scale damage closure, and methods for molecular scale healing are provided. The composition can resolve structural defects by a bio-mimetic close-then heal process. In use, the shape memory polymer can provide molecular scale healing in a structural defect. The methods for molecular scale healing can include heating a composition including a thermoplastic such as fibers, particles or spheres to a level at or above the thermoplastic's melting point, then cooling of the composition below the melting temperature of the thermoplastic. The compositions have the ability to close macroscopic defects repeatedly even if another wound/damage occurs in a previously healed/repaired area.
    Type: Grant
    Filed: April 17, 2020
    Date of Patent: June 14, 2022
    Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Guoqiang Li, Harper Meng
  • Rice cultivar designated ‘PVL01’
    Patent number: 11357191
    Abstract: The herbicide-tolerant rice cultivar designated “PVL01” and its hybrids and derivatives are disclosed. The present invention provides a method for producing rice, wherein said rice is tolerant to a quizalofop herbicide or tolerant to a tepraloxdyim herbicide; wherein said rice belongs to any of (a) variety “PVL01” or (b) a hybrid, derivative, or progeny of “PVL01”. Further provided are methods for producing a hybrid or a new variety by crossing the rice variety “PVL01” with another rice line, one or more times. In another embodiment, this invention allows for single-gene converted plants of “PVL01”. In another embodiment, this invention provides regenerable cells for use in tissue culture of rice plant “PVL01”.
    Type: Grant
    Filed: June 19, 2018
    Date of Patent: June 14, 2022
    Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventor: Steven D. Linscombe
  • Substituted epoxyeicosatrienoic acid (EET) analogs for treatment of kidney disease
    Patent number: 11358968
    Abstract: Described here are EET analogs conjugated to folate receptor ligands such as folic acid or folic acid analogs recognized by and selectively bound by folate receptors and other folate binding proteins and the use of such conjugated EET analogs for targeted delivery of therapeutic agents to folate-receptor bearing cell populations. More particularly, provided herein are EET analogs conjugated to folate receptor ligands and uses of such conjugated EET analogs as kidney targeted therapeutics.
    Type: Grant
    Filed: September 14, 2018
    Date of Patent: June 14, 2022
    Assignee: The Medical College of Wisconsin, Inc.
    Inventors: John D. Imig, John R. Falck, Abdul Hye Khan, Adeniyi Adebesin
  • Molecular verification systems
    Patent number: 11359229
    Abstract: Provided herein are molecular verification (authentication) systems, methods and compositions that use molecular (DNA/RNA) circuitry to enable specific molecularly encrypted solutions.
    Type: Grant
    Filed: September 19, 2017
    Date of Patent: June 14, 2022
    Assignee: President and Fellows of Harvard College
    Inventors: Jongmin Kim, Jocelyn Yoshiko Kishi, Peng Yin, Steven Henry Strassmann, Thomas E. Schaus
  • Fluid injection
    Patent number: 11358105
    Abstract: The present invention generally relates to systems and methods for the control of fluids and, in some cases, to systems and methods for flowing a fluid into and/or out of other fluids. As examples, fluid may be injected into a droplet contained within a fluidic channel, or a fluid may be injected into a fluidic channel to create a droplet. In some embodiments, electrodes may be used to apply an electric field to one or more fluidic channels, e.g., proximate an intersection of at least two fluidic channels. For instance, a first fluid may be urged into and/or out of a second fluid, facilitated by the electric field. The electric field, in some cases, may disrupt an interface between a first fluid and at least one other fluid. Properties such as the volume, flow rate, etc.
    Type: Grant
    Filed: January 11, 2021
    Date of Patent: June 14, 2022
    Assignee: President and Fellows of Harvard College
    Inventors: David A. Weitz, Adam R. Abate, Tony Hung, Pascaline Mary
  • Pulse sequence design protocol
    Patent number: 11360174
    Abstract: Systems and methods are disclosed for a pulse sequence that reduces disorder and/or interaction effects in spin systems. A protocol can be used to design a pulse sequence that includes altering the frame orientation of the spin system with each electromagnetic pulse in the pulse sequence. The frame orientations during the sequence can conform to certain conditions. The number positive rotations along each axis can be the same as the number negative rotations along the respective axis. The number of rotations along one axis should be the same as the number of rotations along the other axes.
    Type: Grant
    Filed: March 6, 2020
    Date of Patent: June 14, 2022
    Assignee: President and Fellows of Harvard College
    Inventors: Mikhail D. Lukin, Hengyun Zhou, Joonhee Choi, Soonwon Choi, Helena Knowles, Renate Landig
  • RNA-guided human genome engineering
    Patent number: 11359211
    Abstract: A method of altering a eukaryotic cell is provided including transfecting the eukaryotic cell with a nucleic acid encoding RNA complementary to genomic DNA of the eukaryotic cell, transfecting the eukaryotic cell with a nucleic acid encoding an enzyme that interacts with the RNA and cleaves the genomic DNA in a site specific manner, wherein the cell expresses the RNA and the enzyme, the RNA binds to complementary genomic DNA and the enzyme cleaves the genomic DNA in a site specific manner.
    Type: Grant
    Filed: April 29, 2019
    Date of Patent: June 14, 2022
    Assignee: President and Fellows of Harvard College
    Inventors: George M. Church, Prashant G. Mali, Luhan Yang
  • Methods and compositions for the treatment of persistent infections and cancer by inhibiting the programmed cell death 1 (PD-1) pathway
    Patent number: 11359013
    Abstract: The present invention provides methods and compositions for the treatment, prevention, or reduction of persistent infections, such as chronic infections, latent infections, and slow infections and cancer. The methods and compositions of the invention are also useful for the alleviation of one or more symptoms associated with such infections and cancer.
    Type: Grant
    Filed: June 18, 2019
    Date of Patent: June 14, 2022
    Assignees: Emory University, Dana-Farber Cancer Institute, Inc., Brigham and Women's Hospital, Inc., President and Fellows of Harvard College
    Inventors: Gordon Freeman, Arlene Sharpe, David M. Dorfman, Rafi Ahmed, Daniel Barber, E. John Wherry
  • Methods for rule-based genome design
    Patent number: 11361845
    Abstract: Methods and systems for designing, testing, and validating genome designs based on rules or constraints or conditions or parameters or features and scoring are described herein.
    Type: Grant
    Filed: June 15, 2017
    Date of Patent: June 14, 2022
    Assignee: President and Fellows of Harvard College
    Inventors: Gleb Kuznetsov, Marc J. Lajoie, Matthieu M. Landon, Michael G. Napolitano, Daniel Bryan Goodman, Christopher J. Gregg, George M. Church, Nili Ostrov
  • SUBWAVELENGTH RESONATOR FOR ACOUSTOPHORETIC PRINTING
    Publication number: 20220176694
    Abstract: A subwavelength resonator for acoustophoretic printing comprises a hollow resonator body for local enhancement of an acoustic field integrated with a nozzle body for delivery of an ink into the acoustic field. The nozzle body has a first end outside the hollow resonator body and a second end inside the hollow resonator body, and includes a fluid channel extending between a fluid inlet at the first end and a fluid outlet at the second end. The fluid channel passes through a side wall of the hollow resonator body and includes at least one bend. During acoustophoretic printing, an ink delivered through the fluid channel of the nozzle body and out of the fluid outlet is exposed to a high-intensity acoustic field.
    Type: Application
    Filed: March 23, 2020
    Publication date: June 9, 2022
    Applicant: President and Fellows of Harvard College
    Inventors: Daniele FORESTI, Aleksandra MARKOVIC, Jennifer A. LEWIS
  • REMODILINS FOR AIRWAY REMODELING AND ORGAN FIBROSIS
    Publication number: 20220177422
    Abstract: Disclosed herein is a class of molecules termed remodilins that are effective in treating asthma, pulmonary fibrosis, and associated disorders. The molecules ameliorate asthma and pulmonary fibrosis symptoms by various mechanisms, including inhibiting airway smooth muscle contractile protein accumulation, reducing airway constrictor hyperresponsiveness, inhibiting bronchial fibroblast transformation into myofibroblasts, and/or treating or preventing airway or pulmonary fibrosis.
    Type: Application
    Filed: April 2, 2020
    Publication date: June 9, 2022
    Applicants: The University of Chicago, The United States of America,as Represented by the Secretary, Department of Health and Human Servic, President and Fellows of Harvard College, IIT Research Institute, Beth Israel Deaconess Medical Center, Inc.
    Inventors: Julian SOLWAY, Nickolai DULIN, Diane Luci, David MALONEY, Chan Young PARK, Jeffrey FREDBERG, David MCCORMICK, Ramaswamy KRISHNAN
  • PROLINE-LOCKED STAPLED PEPTIDES AND USES THEREOF
    Publication number: 20220177522
    Abstract: The present invention provides a new type of alpha-helix nucleating cross-link (“staple”) formed by olefin metathesis of a proline derivative with an alkenyl side chain and another amino acid derivative with an alkenyl side chain. The proline derivatives as described herein have been found to be strong nucleators of alpha-helix formation. The invention also provides moieties for shielding the free amide N—H's at the N-terminus of an alpha-helix, thereby further stabilizing the helix. The proline derivatives, precursors prior to cross-linking, and the cross-linked peptides are provided as well as methods of using and preparing these compounds and peptides.
    Type: Application
    Filed: February 25, 2022
    Publication date: June 9, 2022
    Applicant: President and Fellows of Harvard College
    Inventors: Gregory L. VERDINE, Kazuhiro HAYASHI
  • HIGHLY MULTIPLEXED BASE EDITING
    Publication number: 20220177877
    Abstract: The present disclosure provides highly multiplexed base editing methods and compositions that minimize the induction of DNA damage sensors in eukaryotic cells and maintain cell viability. The disclosed base editing methods improve the survival of eukaryotic cells after large-scale genome editing. These methods are based upon the discovery that use of a dead Cas9 base editor and optimal cell conditions during and after base editing enhances cells' tolerance to and survival following thousands of edits to the genome. Optimal cell conditions after base editing include the use of a combination of small molecule factors and/or inhibitors. These methods are facilitated by the design and use of tens to hundreds to thousands of gRNAs for guiding the base editor to the target sequences. The disclosed methods are capable of inducing between ten and 300,000 edits to the genome of a eukaryotic cell.
    Type: Application
    Filed: March 4, 2020
    Publication date: June 9, 2022
    Applicant: President and Fellows of Harvard College
    Inventors: George M. Church, Oscar Castanon Velasco, Cory J. Smith
  • Method and an apparatus for determining hemodynamic status
    Patent number: 11350828
    Abstract: A device and a method thereof for determining a hemodynamic state of an individual from a magnitude of a perfusion signal or a signal which is a measure of a volume of blood in the thoracic cavity of the individual, wherein the control device is configured to receive a first signal and a heart rate signal, divide the first signal into frames, wherein a frame length is determined from an oscillation period of the heart rate signal, and determine a magnitude of the first signal from at least two frames, so as to obtain a more reliable magnitude of the first signal.
    Type: Grant
    Filed: March 24, 2017
    Date of Patent: June 7, 2022
    Assignee: Imperial College of Science, Technology & Medicine
    Inventors: Darrel Francis, Matthew Shun-Shin, Daniel Keene, Zachary Whinnett
  • Single cell nucleic acid detection and analysis
    Patent number: 11352669
    Abstract: Methods and compositions for digital profiling of nucleic acid sequences present in a sample are provided.
    Type: Grant
    Filed: June 30, 2021
    Date of Patent: June 7, 2022
    Assignee: President and Fellows of Harvard College
    Inventors: Xiaoliang Sunney Xie, Katsuyuki Shiroguchi, Peter A. Sims, Tony Z. Jia
  • Combination therapies for treating infantile spasms and other treatment resistant epilepsies
    Patent number: 11351229
    Abstract: The present invention provides methods of treating infantile spasms in a subject in need thereof. In certain embodiments, the method comprises administering to the subject both vigabatrin (VGB) and insulin-like growth factor 1 (IGF-1), a biologically active fragment thereof, or any derivative thereof.
    Type: Grant
    Filed: April 17, 2018
    Date of Patent: June 7, 2022
    Assignee: Baylor College of Medicine
    Inventors: John W. Swann, Chong L. Lee, John T. Le, James D. Frost, Jr.
  • Mito-lonidamine, compositions and methods of use
    Patent number: 11352382
    Abstract: The present invention relates to mito-lonidamine compounds, compositions and methods of use in the treatment of cancer.
    Type: Grant
    Filed: January 3, 2019
    Date of Patent: June 7, 2022
    Assignees: The Medical College of Wisconsin, Inc., Aix-Marseille Universite
    Inventors: Balaraman Kalyanaraman, Micael J. Hardy, Olivier Ouari