Patents Assigned to Colorado Seminary, which owns and operates The University of Denver
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Patent number: 11337798Abstract: A method for optimizing a shape of a replacement valve leaflet, wherein the shape of the replacement valve leaflet is determined by defining variable parameters of the replacement valve leaflet. The variable parameters may comprise: a valve height; a leaflet coaptation height, a first set of two control points for a first B-spline plane of symmetry; and a second set of two control points for a second B-spline plane tangent to a frame of the valve. The method may further comprise creating iterations of potential shapes of the replacement valve leaflet by changing one or more of the variable parameters using modeling software. The method may also comprise calculating the maximum stresses or strains on each of the potential shapes.Type: GrantFiled: December 6, 2019Date of Patent: May 24, 2022Assignee: Colorado Seminary Which Owns and Operates The University of DenverInventors: Ali Nejatbakhsh Azadani, Mostafa Abbasi
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Patent number: 10839510Abstract: Various arrangements for identifying and grading cancer in tissue samples are presented. A digital image of a stained tissue sample may be acquired. A Shearlet transform may be performed on the digital image of the stained tissue sample. Shearlet coefficients may be calculated based on the performed Shearlet transform of the normalized digital RGB image of the stained tissue sample. A trained neural network may be applied to create a plurality of feature maps using the digital image and Shearlet coefficients, wherein the trained neural network was trained using a plurality of images and Shearlet coefficients of a plurality of digital images. A classifier may be applied to an output of the trained neural network to identify whether cancer is present in the stained tissue sample. A notification may be output that is indicative of a grade of detected cancer in the sample.Type: GrantFiled: August 17, 2016Date of Patent: November 17, 2020Assignee: Colorado Seminary, which owns and operates the University of DenverInventors: Mohammad H. Mahoor, Hadi Rezaeilouyeh, Ali Mollahosseini
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Patent number: 10730607Abstract: A circulation control system for an aerial vehicle. The system comprises an air supply unit attached to the aerial vehicle configured to generate a specified amount of mass air flow; an air delivery system, the air supply unit and the air delivery system being connected via at least one tube that turns at least one right angle; a circulation control wing through which air from the air supply unit is delivered through the air delivery system, the circulation control wing comprising at least one plenum configured to blow the air out of a slot in a trailing edge of the wing, and at least one dual radius flap positioned behind the slot.Type: GrantFiled: November 15, 2017Date of Patent: August 4, 2020Assignee: Colorado Seminary Which Owns and Operates the University of DenverInventors: Konstantinos Kanistras, Pranith Chander Saka, Matthew J. Rutherford, Kimon P. Valavanis
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Patent number: 10618675Abstract: A mobile self-leveling landing platform vehicle is disclosed that includes a landing surface and one or more wheel assemblies. Each wheel assembly includes a wheel, a control arm coupled with the wheel and the body of the landing platform vehicle, and an actuator coupled with the control arm and the body of the platform vehicle. Methods for self-leveling the landing platform vehicle are also disclosed.Type: GrantFiled: May 20, 2019Date of Patent: April 14, 2020Assignee: Colorado Seminary, which owns and operates the University of DenverInventors: Stephen A. Conyers, Nikolaos Vitzilaios, Matthew J. Rutherford, Kimon P. Valavanis
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Patent number: 10588534Abstract: Systems and methods are disclosed to detect and/or classify electrophysiological signals as motor events.Type: GrantFiled: December 5, 2016Date of Patent: March 17, 2020Assignee: Colorado Seminary, which owns and operates the University of DenverInventors: Mohammad H. Mahoor, Soroush Niketeghad, Adam O. Hebb, Sara J. Hanrahan, Joshua Nedrud, Hosein M. Golshan
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Patent number: 10578703Abstract: Full-cycle rapid scan (RS) electron paramagnetic resonance (EPR) can be performed without the instability of prior art methods and with a higher scan rate than traditional half-scan methods. In particular, a full scan is performed, but the constant RF driving B-field can be mathematically represented as two step functions, each corresponding to one half of a full scan cycle. This mathematical representation can be carried through the deconvolution such that two deconvolutions, one for the up cycle and one for the down cycle, can be performed. The solutions to these two deconvolutions can then be summed to give a single spectrum having a higher signal-to-noise ratio than half-cycle RS scans.Type: GrantFiled: March 30, 2018Date of Patent: March 3, 2020Assignee: Colorado Seminary Which Owns and Operates the University of DenverInventor: Mark Tseytlin
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Patent number: 10538339Abstract: A mobile self-leveling landing platform vehicle is disclosed that includes a landing surface and one or more wheel assemblies. Each wheel assembly includes a wheel, a control arm coupled with the wheel and the body of the landing platform vehicle, and an actuator coupled with the control arm and the body of the platform vehicle. Methods for self-leveling the landing platform vehicle are also disclosed.Type: GrantFiled: June 19, 2015Date of Patent: January 21, 2020Assignee: Colorado Seminary, which owns and operates the University of DenverInventors: Stephen A. Conyers, Nikolaos Vitzilaios, Matthew J. Rutherford, Kimon P. Valavanis
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Patent number: 10540782Abstract: A method for estimating a pose of a first object in relation to a second object, the second object comprising a visual marker comprising a plurality of ellipses comprises capturing a video image of the visual marker with an image capture device on the first object, then pre-processing frames of the video image on a graphics processing unit. The method comprises detecting the visual marker by finding contours in the frames to identify the plurality of ellipses and determining that a pattern of the plurality of ellipses match a known pattern of the visual marker. Then the method comprises obtaining coordinates of two or more of the plurality of ellipses of the visual marker, estimating the pose of the first object in relation to the second object by inputting the coordinates of the plurality of ellipses into a pose estimation algorithm, and filtering results of the pose estimation algorithm.Type: GrantFiled: November 15, 2017Date of Patent: January 21, 2020Assignee: Colorado Seminary Which Owns and Operates the University of DenverInventors: Alessandro Benini, Matthew J. Rutherford, Kimon P. Valavanis
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Patent number: 10509091Abstract: Various systems and methods for detecting electron spins using electron paramagnetic resonance are described. An excitation signal generator configured to generate an excitation signal of varying amplitude and phase as compared to a reference signal may be present. A crossed-loop resonator configured to isolate a detection signal produced by the excitation signal exciting an object with a magnetic field may also be present. Further, a detection device configured to detect electron spins of the object using the detection signal isolated by the crossed-loop resonator may be present.Type: GrantFiled: March 7, 2013Date of Patent: December 17, 2019Assignee: Colorado Seminary, which owns and operates the University of DenverInventors: Mark Tseitlin, Richard Quine, George Rinard, Gareth Eaton, Sandra Eaton
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Patent number: 10502797Abstract: Embodiments of the invention are directed toward a crossed-loop electron paramagnetic resonance resonator comprising a first resonator having a first resonator axis; and a second resonator having a second resonator axis. The first resonator axis and the second resonator axis can be substantially perpendicular. Either or both the first resonator and the second resonator can be a ribbon resonator having a plurality of metallic ribbons formed in a loop. Each metallic ribbon can include a central axis. The plurality of metallic ribbons can be arranged parallel relative one to another.Type: GrantFiled: July 19, 2013Date of Patent: December 10, 2019Assignee: Colorado Seminary, Which owns and operates the University of DenverInventors: George Rinard, Gareth Eaton
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Patent number: 10343794Abstract: A mobile self-leveling landing platform vehicle is disclosed that includes a landing surface and one or more wheel assemblies. Each wheel assembly includes a wheel, a control arm coupled with the wheel and the body of the landing platform vehicle, and an actuator coupled with the control arm and the body of the platform vehicle. Methods for self-leveling the landing platform vehicle are also disclosed.Type: GrantFiled: June 18, 2018Date of Patent: July 9, 2019Assignee: COLORADO SEMINARY, which owns and operates the University of DenverInventors: Stephen A. Conyers, Nikolaos Vitzilaios, Matthew J. Rutherford, Kimon P. Valavanis
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Patent number: 10267734Abstract: Provided are inexpensive devices and methods for obtaining emission or scattering spectra of multiple particles simultaneously and for characterizing the particles based on their emission or scattering spectra. The disclosed devices and methods are useful for analyzing multiple particles to determine one or more characteristics of the particles, such as size, type, elastic scattering, fluorescence and/or Raman characteristics, for distinguishing between biological and non-biological particles, and for biomedical assaying applications. Laboratory or research grade spectroscopic devices are described. Smartphone-based spectroscopic devices are also described, where various components of a smartphone are used for data collection and analysis purposes.Type: GrantFiled: January 7, 2015Date of Patent: April 23, 2019Assignee: Colorado Seminary Which Owns and Operates the University of DenverInventors: Donald Ray Huffman, John Alexander Huffman
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Patent number: 10145950Abstract: A RADAR apparatus may be used in target detection and/or avoidance. The RADAR apparatus may include a microwave front end configured to transmit and receive RF signals, an analog signal conditioning module coupled with the microwave front end module that conditions RF signals received at the microwave front end module, and a digital signal processing module coupled with the analog signal conditioning module that detects presence and range of one or more targets based on the filtered RF signals.Type: GrantFiled: March 10, 2014Date of Patent: December 4, 2018Assignee: Colorado Seminary, Which Owns and Operates the University of DenverInventors: Moses A. Allistair, Kimon P. Valavanis, Matthew J. Rutherford
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Patent number: 9971021Abstract: An unmanned aerial vehicle (UAV) radar apparatus may be used in aircraft detection and avoidance. The radar apparatus may include an RF front end configured to transmit and receive RF signals, a filtering module coupled with the RF front end module that filters RF signals received at the RF front end module, and a target data processing module coupled with the filtering module that detects and identifies one or more targets based on the filtered RF signals. Avoidance procedures may be initiated based on the identification and detection of one or more targets.Type: GrantFiled: April 25, 2012Date of Patent: May 15, 2018Assignee: Colorado Seminary Which Owns and Operates the University of DenverInventors: Allistair A. Moses, Matthew J. Rutherford, Kimon P. Valavanis
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Patent number: 9474796Abstract: The genetically modified hemorrhagic fever virus of this invention possesses a viral ovarian tumor protease with decreased ability to remove ubiquitin (Ub) and ISG15 tags that the human organism uses to label proteins for removal. Unlike complete knockout strains, the modified virus retains enough activity for replication in a human cell line. This creates an immunogenic and non-pathogenic virus that can be used as an effective live vaccine agent.Type: GrantFiled: March 14, 2013Date of Patent: October 25, 2016Assignees: The United States of America, as Represented by the Secretary, Department of Health and Human Services, Colorado Seminary, which owns and operates the University of DenverInventors: Eric Bergeron, Scott Dusan Pegan, Stuart T. Nichol, Michelle Kay Deaton
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Patent number: 9387940Abstract: A docking system for an unmanned aerial vehicle (UAV) is described that provides a stable landing and take-off area as well as, in some embodiments, refueling and/or data transfer capabilities. The docking system may be portable to provide a ready docking area for a UAV in areas that may not otherwise be suitable for UAV operation. The docking system may include a landing surface, an orientation mechanism that adjusts the landing surface to provide a level landing area, and an alignment mechanism coupled with the landing surface that moves a UAV resting on the landing surface to a predetermined location on the landing surface for automated refueling of the UAV. A latching mechanism may secure the UAV to the landing surface when the UAV is located at the predetermined location.Type: GrantFiled: November 9, 2011Date of Patent: July 12, 2016Assignee: Colorado Seminary Which Owns and Operates the University of DenverInventors: Roy Godzdanker, Kimon P. Valavanis, Matthew J. Rutherford
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Publication number: 20140336221Abstract: This invention provides a family of compounds that inhibit Class II fructose 1,6-bisphosphate aldolase (FBA), which is implicated in the pathogenic activity of a broad range of bacterial and parasitic agents. The compounds were identified by empirical testing, and provide a basis for further derivatization and optimization of 8-hydroxyquinoline-2-carboxylic acid and related compounds. Crystal structure shows that the compounds don't bind directly to the catalytic site of the enzyme, and so are not defined simply as substrate analogs. Instead, they create a pocket by induced fit, resulting a powerful and specific inhibitory effect on FBA activity.Type: ApplicationFiled: May 8, 2014Publication date: November 13, 2014Applicants: Colorado Seminary, Which Owns and Operates The University Of Denver, Regis UniversityInventors: Scott Dusan Pegan, Kateri Ahrendt, Glenn C. Capodagli, Bryan Cowen
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Patent number: 8735167Abstract: Provided is a photoamplified fluorescence turn-off assay where a masked photosensitizer is mixed with a fluorescent molecule. This mixture is brightly fluorescent because the masked photosensitizer is not capable of quenching the fluorophore. When the photosensitizer is released and amplified, the photosensitizer quenches the emission of fluorophores very efficiently.Type: GrantFiled: August 20, 2008Date of Patent: May 27, 2014Assignee: Colorado Seminary, which owns and operates The University of DenverInventors: Andrei G. Kutateladze, Alexei Kurchan, Rudresha Kottani, Janaki Majjigapu
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Publication number: 20140139366Abstract: An unmanned aerial vehicle (UAV) radar apparatus may be used in aircraft detection and avoidance. The radar apparatus may include an RF front end configured to transmit and receive RF signals, a filtering module coupled with the RF front end module that filters RF signals received at the RF front end module, and a target data processing module coupled with the filtering module that detects and identifies one or more targets based on the filtered RF signals. Avoidance procedures may be initiated based on the identification and detection of one or more targets.Type: ApplicationFiled: April 25, 2012Publication date: May 22, 2014Applicant: Colorado Seminary, which owns and Operates The University of DenverInventors: Allistair A. Moses, Matthew J. Rutherford, Kimon P. Valavanis
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Patent number: D818046Type: GrantFiled: November 23, 2016Date of Patent: May 15, 2018Assignee: Colorado Seminary Which Owns and Operates the University of DenverInventors: Alessandro Benini, Matthew J. Rutherford, Kimon P. Valavanis