Patents Assigned to Combigene AB
  • Vector
    Patent number: 11072804
    Abstract: The present invention relates to a recombinant adeno-associated viral (r AAV) vector comprising neuropeptide Y (NPY) coding sequence and neuropeptide Y2 receptor (NPY2R) coding sequence. The invention further relates to a AAV particle comprising said vector, wherein the vector is encapsulated by adeno-associated virus (AAV) capsid proteins. Also, a pharmaceutical composition comprising said AAV particle, for use in the prevention or treatment of a neurological disorder in mammals, such as epilepsy.
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: July 27, 2021
    Assignee: Combigene AB
    Inventor: Merab Kokaia
  • Use of nucleic acid sequences for the treatment of epilepsy
    Patent number: 8901094
    Abstract: The present invention relates to the use of one or more expression vectors comprising certain nucleic acid sequences encoding a combination of NPY and/or one or more of its receptors (Y1, Y2, Y4, Y5, y6), and/or galanin and/or one or more of its receptors (GALR1, GALR2, GALR3), and/or somatostatin and/or one or more of its receptors (SST1, SST2, SST3, SST4, SST5), in the preparation of a medicament for treatment of a disorder of the nervous system, such as a neurological or a psychiatric disease chosen from epilepsy, depression, and anxiety. The invention further relates to vectors that comprise nucleic acid sequences encoding the above combination, to compositions comprising such vectors and to a method of delivery and expression of the above combination of nucleic acid sequences into cells of the nervous system to treat neurological or psychiatric diseases in humans or animals.
    Type: Grant
    Filed: July 4, 2007
    Date of Patent: December 2, 2014
    Assignee: Combigene AB
    Inventors: Merab Kokaia, David Woldbye
  • Use of nucleic acid sequences for the treatment of neuralogical and psychiatric diseases and compositions
    Publication number: 20100010070
    Abstract: The present invention relates to the use of one or more expression vectors comprising certain nucleic acid sequences encoding a combination of NPY and/or one or more of its receptors (Y1, Y2, Y4, Y5, y6), and/or galanin and/or one or more of its receptors (GALR1, GALR2, GALR3), and/or somatostatin and/or one or more of its receptors (SST1, SST2, SST3, SST4, SST5), in the preparation of a medicament for treatment of a disorder of the nervous system, such as a neurological or a psychiatric disease chosen from epilepsy, depression, and anxiety. The invention further relates to vectors that comprise nucleic acid sequences encoding the above combination, to compositions comprising such vectors and to a method of delivery and expression of the above combination of nucleic acid sequences into cells of the nervous system to treat neurological or psychiatric diseases in humans or animals.
    Type: Application
    Filed: July 4, 2007
    Publication date: January 14, 2010
    Applicant: Combigene AB
    Inventors: Merab Kokaia, David Woldby