Patents Assigned to COMBIMAB, INC
  • THERAPEUTIC PEPTIDES
    Publication number: 20140322302
    Abstract: Therapeutic peptides having guanylyl cyclase C agonist activity are disclosed. The therapeutic peptides are analogues of the E. coli STa peptide with non-natural amino acid, isosteric or D-amino acid substituents. The therapeutic peptides are useful in the treatment of chronic ideopathic constipation, inflammatory bowel disease, and other diseases. Pharmaceutical compositions comprising the therapeutic peptides are also disclosed.
    Type: Application
    Filed: May 11, 2014
    Publication date: October 30, 2014
    Applicant: COMBIMAB, INC
    Inventors: Henry Wolfe, Reinhard Ebner
  • Therapeutic peptides
    Patent number: 8748575
    Abstract: Therapeutic peptides having guanylyl cyclase C agonist activity are disclosed. The therapeutic peptides are analogues of the E. coli STa peptide with non-natural amino acid, isosteric or D-amino acid substituents. The therapeutic peptides are useful in the treatment of chronic ideopathic constipation, inflammatory bowel disease, and other diseases. Pharmaceutical compositions comprising the therapeutic peptides are also disclosed.
    Type: Grant
    Filed: June 8, 2011
    Date of Patent: June 10, 2014
    Assignee: Combimab, Inc.
    Inventors: Henry Wolfe, Reinhard Ebner
  • Therapeutic Peptides
    Publication number: 20140038881
    Abstract: Therapeutic peptides having guanylyl cyclase C agonist activity are disclosed. The therapeutic peptides are analogues of the E. coli STa peptide with non-natural amino acid, isosteric or D-amino acid substituents. The therapeutic peptides are useful in the treatment of chronic ideopathic constipation, inflammatory bowel disease, and other diseases. Pharmaceutical compositions comprising comprising the therapeutic peptides are also disclosed.
    Type: Application
    Filed: June 8, 2011
    Publication date: February 6, 2014
    Applicant: COMBIMAB, INC
    Inventors: Henry Wolfe, Reinhard Ebner