Patents Assigned to COMBISEP
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Patent number: 7534335Abstract: A multiplexed, absorbance-based electrophoresis system for analyzing multiple samples simultaneously without use of a mask or slit comprising a light source, a planar array of capillary tubes and a detector positioned off-axis with the light source and positioned on-axis with and parallel to the planar array of capillary tubes. Another embodiment includes a vent valve directly attached to the reservoir manifold for venting pressure from the reservoir. Other embodiments include vacuum attached to the capillary tubes to increase the speed of detection.Type: GrantFiled: April 7, 2004Date of Patent: May 19, 2009Assignee: Combisep, Inc.Inventors: Kevin C. Kennedy, Thomas J. Kurt
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Patent number: 7497937Abstract: A multiplexed, absorbance-based microfabricated chip electrophoresis system, microfabricated chip, and method of use are included for the detection and identification of protein species. The microfabricated chip electrophoresis system capable of analyzing multiple samples simultaneously. The system uses a microfabricated chip having a sample chamber for first dimension separation of a sample, a first planar array of channels for second dimension separation of the sample approximately perpendicular the sample chamber, and a barrier separating the sample chamber from the first planar array of channels during the first dimension separation. In use, the sample is placed into a sample chamber, a barrier is established around the sample chamber, the sample is isoelectric focused within the sample chamber, the barrier is then removed, and the sample separated in the first array of channels by molecular weight.Type: GrantFiled: September 3, 2004Date of Patent: March 3, 2009Assignee: Combisep, Inc.Inventors: Edward S. Yeung, Ho-Ming Pang, Futian Han
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Publication number: 20070131870Abstract: A multiplexed capillary electrophoresis (CE) method using fluorescence detection for a plurality of samples is improved economically and in terms of instrument complexity by irradiating the plurality of samples with a single non-coherent light source as the excitation light source for all of the channels. The preferred light source is a light-emitting-diode (LED).Type: ApplicationFiled: December 12, 2005Publication date: June 14, 2007Applicant: COMBISEPInventors: Ho Pang, Wei Wei
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Patent number: 7118659Abstract: An electrophoresis instrument for analyzing multiple samples having a loading system. The loading system having a carriage moveable between an external station and a sampling station. The carriage having at least one tray upon the carriage. The sampling station being adapted for sampling the tray by an array of capillary tubes.Type: GrantFiled: February 27, 2003Date of Patent: October 10, 2006Assignee: Combisep, Inc.Inventors: Thomas J. Kurt, Kevin C. Kennedy
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Patent number: 7083711Abstract: A separation matrix for capillary electrophoresis of single-stranded nucleic acids is disclosed. The matrix comprises an aqueous buffer containing a denaturant and (hydroxypropyl)methyl cellulose.Type: GrantFiled: February 21, 2003Date of Patent: August 1, 2006Assignee: Combisep, Inc.Inventor: Wei Wei
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Publication number: 20060049051Abstract: A multiplexed, absorbance-based microfabricated chip electrophoresis system, microfabricated chip, and method of use are included for the detection and identification of protein species. The microfabricated chip electrophoresis system capable of analyzing multiple samples simultaneously. The system uses a microfabricated chip having a sample chamber for first dimension separation of a sample, a first planar array of channels for second dimension separation of the sample approximately perpendicular the sample chamber, and a barrier separating the sample chamber from the first planar array of channels during the first dimension separation. In use, the sample is placed into a sample chamber, a barrier is established around the sample chamber, the sample is isoelectric focused within the sample chamber, the barrier is then removed, and the sample separated in the first array of channels by molecular weight.Type: ApplicationFiled: September 3, 2004Publication date: March 9, 2006Applicant: CombiSep, Inc.Inventors: Edward Yeung, Ho-Ming Pang, Futian Han
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Patent number: 6969452Abstract: Disclosed is a two-dimensional protein separation method. It makes separating a protein sample by chromatofocusing into a plurality of aliquots, and then loading each aliquot into a separate capillary tube; and separating each aliquot by multiplexed capillary electrophoresis to produce a two-dimensional array of separated proteins. A preferred integrated buffer for this system is also disclosed.Type: GrantFiled: February 28, 2003Date of Patent: November 29, 2005Assignee: Combisep, Inc.Inventors: Yan He, Ho-Ming Pang, Siquan Luo, Futian Han
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Patent number: 6833919Abstract: A multiplexed, absorbance-based electrophoresis system for analyzing multiple samples simultaneously without use of a mask or slit comprising a light source, a planar array of capillary tubes and a detector positioned off-axis with the light source and positioned on-axis with and parallel to the planar array of capillary tubes. Other embodiments include vacuum use attached to the capillary tubes to increase the speed of detection.Type: GrantFiled: October 11, 2002Date of Patent: December 21, 2004Assignee: COMBISEPInventors: Jeremy R. Kenseth, Ho-Ming Pang, Roy F. Strasburg
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Patent number: 6833062Abstract: A multiplexed, absorbance-based electrophoresis system for analyzing multiple samples simultaneously without use of a mask or slit comprising a light source, a planar array of capillary tubes and a detector positioned off-axis with the light source and positioned on-axis with and parallel to the planar array of capillary tubes. Other embodiments include vacuum use attached to the capillary tubes to increase the speed of detection.Type: GrantFiled: February 28, 2003Date of Patent: December 21, 2004Assignee: Combisep, Inc.Inventors: Kevin C. Kennedy, Thomas J. Kurt
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Publication number: 20040188255Abstract: A multiplexed, absorbance-based electrophoresis system for analyzing multiple samples simultaneously without use of a mask or slit comprising a light source, a planar array of capillary tubes and a detector positioned off-axis with the light source and positioned on-axis with and parallel to the planar array of capillary tubes. Another embodiment includes a vent valve directly attached to the reservoir manifold for venting pressure from the reservoir. Other embodiments include vacuum attached to the capillary tubes to increase the speed of detection.Type: ApplicationFiled: April 7, 2004Publication date: September 30, 2004Applicant: CombiSep, Inc.Inventors: Kevin C. Kennedy, Thomas J. Kurt
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Publication number: 20040168921Abstract: A multiplexed, absorbance-based electrophoresis system for analyzing multiple samples simultaneously without use of a mask or slit comprising a light source, a planar array of capillary tubes and a detector positioned off-axis with the light source and positioned on-axis with and parallel to the planar array of capillary tubes. Other embodiments include vacuum use attached to the capillary tubes to increase the speed of detection.Type: ApplicationFiled: February 28, 2003Publication date: September 2, 2004Applicant: CombiSepInventors: Kevin C. Kennedy, Thomas J. Kurt
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Publication number: 20040168919Abstract: An electrophoresis instrument for analyzing multiple samples having a loading system. The loading system having a carriage moveable between an external station and a sampling station. The carriage having at least one tray upon the carriage. The sampling station being adapted for sampling the tray by an array of capillary tubes.Type: ApplicationFiled: February 27, 2003Publication date: September 2, 2004Applicant: CombiSep, Inc.Inventors: Thomas J. Kurt, Kevin C. Kennedy
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Publication number: 20040168915Abstract: Disclosed is a two-dimensional protein separation method. It makes separating a protein sample by chromatofocusing into a plurality of aliquots, and then loading each aliquot into a separate capillary tube; and separating each aliquot by multiplexed capillary electrophoresis to produce a two-dimensional array of separated proteins. A preferred integrated buffer for this system is also disclosed.Type: ApplicationFiled: February 28, 2003Publication date: September 2, 2004Applicant: CombiSep, Inc.Inventors: Yan He, Ho-Ming Pang, Siquan Luo, Futian Han