Abstract: A two-compartment capsule includes a body, a diaphragm between, which seals off the body and provides a first compartment to hold a first dry ingredient, and a cap applied to the body whereby a space between the inner portion of the cap and the diaphragm defines a second compartment for holding a second dry ingredient. This disclosure also provides particular formulations for use in such a capsule. Examples include a probiotic, a digestive enzyme, an expectorant, a bronchodilator, a stool softener, a platelet aggregation inhibitor, a form or derivative of vitamin E, a statin, and aspirin.

Abstract: A comestible gelatin capsule 10 for holding a substance in hermetic isolation includes a capsule body 12, a diaphragm 14 located within the capsule body and an end cap 16. Overlapping open end regions of walls 22 and 28 of the capsule body 12 and of the diaphragm 14, respectively, are fused to one another in a fusion welding process wherein the end regions undergo partial phase change so as to form a circumferential fused homogeneous sealing zone 36. The overlapping end regions are bent inwardly in the fusion welding process such that a portion of the wall 22 extends inwardly across a portion of the wall 28 thereby restricting axial movement of the capsule body and the diaphragm relative to one another forming a stable robust and effective hermetic seal.

Abstract: A two-compartment capsule includes a body, a diaphragm between which seals off the body and provides a first compartment to hold a first ingredient, and a cap applied to the body whereby a space between the inner portion of the cap and the diaphragm defines a second compartment for holding a second ingredient. This disclosure also provides certain ranges for the volumes of the first compartment and the second compartment, as well as a volume ratio of the first compartment to the second compartment, lengths of the first and second compartments, and the length of contact between a sidewall of the diaphragm and a sidewall of the body. Furthermore, particular ingredients and formulations for the two-compartment capsule where volume is critical for a therapeutic effect are disclosed.

Abstract: A multi-compartment capsule may include a body, a diaphragm between, which seals off the body and provides a first compartment to hold an ingredient, and a cap applied to the body whereby a space between the inner portion of the cap and the diaphragm defines a second compartment for holding an oil. A two-compartment capsule may include a body, a diaphragm between, which seals off the body and provides a first compartment to hold an oil, and a cap applied to the body whereby a space between the inner portion of the cap and the diaphragm defines a second compartment for holding an ingredient. The ingredient may have increased bioavailability after exposure to the oil. This disclosure also provides particular formulations for use in such a capsule.

Abstract: A multi-compartment capsule may include a body, a diaphragm between, which seals off the body and provides a first compartment to hold an ingredient, and a cap applied to the body whereby a space between the inner portion of the cap and the diaphragm defines a second compartment for holding an oil. A two-compartment capsule may include a body, a diaphragm between, which seals off the body and provides a first compartment to hold an oil, and a cap applied to the body whereby a space between the inner portion of the cap and the diaphragm defines a second compartment for holding an ingredient. The ingredient may have increased bioavailability after exposure to the oil. This disclosure also provides particular formulations for use in such a capsule.

Abstract: A comestible gelatin capsule 10 for holding a substance in hermetic isolation includes a capsule body 12, a diaphragm 14 located within the capsule body and an end cap 16. Overlapping open end regions of walls 22 and 28 of the capsule body 12 and of the diaphragm 14, respectively, are fused to one another in a fusion welding process wherein the end regions undergo partial phase change so as to form a circumferential fused homogeneous sealing zone 36. The overlapping end regions are bent inwardly in the fusion welding process such that a portion of the wall 22 extends inwardly across a portion of the wall 28 thereby restricting axial movement of the capsule body and the diaphragm relative to one another forming a stable robust and effective hermetic seal.

Abstract: A two-compartment capsule includes a body, a diaphragm between, which seals off the body and provides a first compartment to hold a first dry ingredient, and a cap applied to the body whereby a space between the inner portion of the cap and the diaphragm defines a second compartment for holding a second dry ingredient. This disclosure also provides particular formulations for use in such a capsule. Examples include a probiotic, a digestive enzyme, an expectorant, a bronchodilator, a stool softener, a platelet aggregation inhibitor, a form or derivative of vitamin E, a statin, and aspirin.

Abstract: A two-compartment capsule includes a body, a diaphragm between which seals off the body and provides a first compartment to hold a first ingredient, and a cap applied to the body whereby a space between the inner portion of the cap and the diaphragm defines a second compartment for holding a second ingredient. This disclosure also provides certain ranges for the volumes of the first compartment and the second compartment, as well as a volume ratio of the first compartment to the second compartment, lengths of the first and second compartments, and the length of contact between a sidewall of the diaphragm and a sidewall of the body. Furthermore, particular ingredients and formulations for the two-compartment capsule where volume is critical for a therapeutic effect are disclosed.

Abstract: A method of manufacturing a capsule 12 for holding a substance 14 including providing a capsule body 2 having a closed end 5, an opposed open end 6 and a predetermined length defined between the ends 5, 6; providing a diaphragm 4 having a closed end 7, an opposed open end 8 and a predetermined length defined between the ends 7, 8; partially filling the body 2 with substance 14; inserting the closed end 7 of the diaphragm 4 into the open end 6 of the body 2 such that regions of the body 2 and the diaphragm 4 overlap one another with the open ends of the capsule body 2 and the diaphragm 4 being flush, thereby closing off the open end 6 of the body 2 and defining a chamber 104 within which the substance 14 is held; and heat welding the flush ends of the body 2 and the diaphragm 4 to one another to hermetically seal the chamber 104.