Patents Assigned to CoMentis, Inc.
  • Chromane compounds
    Patent number: 9242973
    Abstract: The present invention provides a hydrate of N-[(4S)-2-amino-2?,2?-dimethyldispiro[1,3-oxazole-4,4?-chromene-3?,3?-oxetan]-6?-yl]-5-chloropyridine-2-carboxamide which is useful as an active ingredient of a pharmaceutical composition, in particular, a pharmaceutical composition for preventing or treating diseases or conditions associated with and/or mediated by ?-secretase activity, hydrolysis of a ?-secretase site of a ?-amyloid precursor protein, and/or ?-amyloid protein accumulation, including a pharmaceutical composition for preventing or treating diseases including, but not limited to, Glaucoma, MCI (Mild cognitive impairment) or Alzheimer's disease, especially, Alzheimer's disease.
    Type: Grant
    Filed: January 22, 2015
    Date of Patent: January 26, 2016
    Assignee: COMENTIS, INC.
    Inventors: Ryosuke Munakata, Makoto Inoue, Hiroaki Tominaga, Shingo Yamasaki, Yasuhiro Shiina, Kiyohiro Samizu, Hisao Hamaguchi, Lin Hong
  • Chromane compounds
    Patent number: 8975415
    Abstract: The present invention provides a compound which is useful as an active ingredient of a pharmaceutical composition, in particular, a pharmaceutical composition for preventing or treating diseases or conditions associated with and/or mediated by ?-secretase activity, hydrolysis of a ?-secretase site of a ?-amyloid precursor protein, and/or ?-amyloid protein accumulation, including a pharmaceutical composition for preventing or treating diseases including, but not limited to, Glaucoma, MCI (Mild cognitive impairment) or Alzheimer's disease, especially, Alzheimer's disease.
    Type: Grant
    Filed: February 27, 2014
    Date of Patent: March 10, 2015
    Assignee: CoMentis, Inc.
    Inventors: Ryosuke Munakata, Makoto Inoue, Hiroaki Tominaga, Shingo Yamasaki, Yasuhiro Shina, Kiyohiro Samizu, Hisao Hamaguchi, Lin Hong
  • CHROMANE COMPOUNDS
    Publication number: 20140179695
    Abstract: The present invention provides a compound which is useful as an active ingredient of a pharmaceutical composition, in particular, a pharmaceutical composition for preventing or treating diseases or conditions associated with and/or mediated by ?-secretase activity, hydrolysis of a ?-secretase site of a ?-amyloid precursor protein, and/or ?-amyloid protein accumulation, including a pharmaceutical composition for preventing or treating diseases including, but not limited to, Glaucoma, MCI (Mild cognitive impairment) or Alzheimer's disease, especially, Alzheimer's disease.
    Type: Application
    Filed: February 27, 2014
    Publication date: June 26, 2014
    Applicants: CoMentis, Inc., ASTELLAS PHARMA INC.
    Inventors: Ryosuke MUNAKATA, Makoto INOUE, Hiroaki TOMINAGA, Shingo YAMASAKI, Yasuhiro SHIINA, Kiyohiro SAMIZU, Hisao HAMAGUCHI, Lin HONG
  • SULFONAMIDO PYRROLIDINE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF
    Publication number: 20130059840
    Abstract: Described herein are novel beta-secretase inhibitors and methods for their use, including methods of treating Alzheimer's disease.
    Type: Application
    Filed: October 4, 2010
    Publication date: March 7, 2013
    Applicant: CoMentis, Inc.
    Inventors: Geoffrey M. Bilcer, Sudha V. Ankala
  • (3-hydroxy-4-amino-butan-2-yl) -3- (2-thiazol-2-yl-pyrrolidine-1-carbonyl) benzamide derivatives and related compounds as beta-secretase inhibitors for treating
    Patent number: 8299267
    Abstract: The present invention provides novel beta-secretase inhibitors and methods for their use, including methods of treating of Alzheimer's disease.
    Type: Grant
    Filed: September 24, 2008
    Date of Patent: October 30, 2012
    Assignees: CoMentis, Inc., Purdue Research Foundation
    Inventors: Arun K. Ghosh, Chunfeng Liu, Thippeswamy Devasamudram, Hui Lei, Lisa M. Swanson, Sudha V. Ankala, John C. Lilly, Geoffrey M. Bilcer
  • 4-substituted quinuclidine derivatives, methods of production, pharmaceutical uses thereof
    Patent number: 8114891
    Abstract: The present invention relates to compounds and formulations capable of affecting nicotinic acetylcholine receptors (nAChRs), for example, as modulators of specific nicotinic receptor subtypes (specifically, the alpha7 nAChR subtype). The present invention also relates to methods for treating a wide variety of conditions and disorders, particularly those associated with dysfunction of the central and autonomic nervous systems.
    Type: Grant
    Filed: September 30, 2008
    Date of Patent: February 14, 2012
    Assignee: CoMentis, Inc.
    Inventors: Jürg R. Pfister, Meenakshi S. Venkatraman, Xiaoming Zhang
  • ISOPHTHALAMIDE DERIVATIVES INHIBITING BETA-SECRETASE ACTIVITY
    Publication number: 20100286145
    Abstract: The present invention provides novel beta-secretase inhibitors and methods for their use, including methods of treating of Alzheimer's disease.
    Type: Application
    Filed: July 25, 2008
    Publication date: November 11, 2010
    Applicants: CoMentis, Inc., Purdue Research Foundation
    Inventors: Arun K. Ghosh, Chunfeng Liu, Thippeswamy Devasamudram, Hui Lei, Lisa M. Swanson, Sudha V. Ankala, John C. Lilly, Geoffrey M. Bilcer
  • Hydroxyethylene-based ?-secretase inhibitors and use thereof
    Patent number: 7659289
    Abstract: The present invention provides novel beta-secretase inhibitors and methods for their use, including methods of treating of Alzheimer's disease.
    Type: Grant
    Filed: September 19, 2005
    Date of Patent: February 9, 2010
    Assignees: CoMentis, Inc., Oklahoma Medical Research Foundation, The Board of Trustees of the University of Illinois
    Inventors: Arun K. Ghosh, Hui Lei, Thippeswamy Devasamudram, Jordan J. N. Tang, Geoffrey M. Bilcer, Chunfeng Liu
  • 4-SUBSTITUTED QUINUCLIDINE DERIVATIVES, METHODS OF PRODUCTION, AND PHARMACEUTICAL USES THEREOF
    Publication number: 20090088418
    Abstract: The present invention relates to compounds and formulations capable of affecting nicotinic acetylcholine receptors (nAChRs), for example, as modulators of specific nicotinic receptor subtypes (specifically, the alpha7 nAChR subtype). The present invention also relates to methods for treating a wide variety of conditions and disorders, particularly those associated with dysfunction of the central and autonomic nervous systems.
    Type: Application
    Filed: September 30, 2008
    Publication date: April 2, 2009
    Applicant: CoMentis, Inc.
    Inventors: Jurg R. Pfister, Meenakshi S. Venkatraman, Xiaoming Zhang
  • Compounds which inhibit beta-secretase activity and methods of use
    Patent number: 7504420
    Abstract: The present invention provides novel beta-secretase inhibitors and methods for their use, including methods of treating Alzheimer's disease.
    Type: Grant
    Filed: August 9, 2006
    Date of Patent: March 17, 2009
    Assignees: CoMentis, Inc., The Board of Trustees of the University of Illinois, Oklahoma Medical Research Foundation, Purdue Research Foundation
    Inventors: Arun K. Ghosh, Nagaswamy Kumaragurubaran, Chunfeng Liu, Thippeswamy Devasamudram, Hui Lei, Lisa M. Swanson, Sudha V. Ankala, Jordan J. N. Tang, Geoffrey M. Bilcer
  • Bicyclic Compounds Which Inhibit Beta-Secretase Activity and Methods of Use Thereof
    Publication number: 20080207527
    Abstract: The present invention provides bicyclic beta-secretase inhibitors and methods for their use, including methods of treating of Alzheimer's disease.
    Type: Application
    Filed: September 19, 2005
    Publication date: August 28, 2008
    Applicants: CoMentis, Inc., The Board of Trutees of the University of Illinois, Oklahoma Medical Research Foundation
    Inventors: Arun K. Ghosh, Hui Lei, Thippeswamy Devasamudram, Chunfeng Liu, Jordan J.N. Tang, Geoffrey Bilcer
  • COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF
    Publication number: 20080176939
    Abstract: The present invention provides novel beta-secretase inhibitors and methods for their use, including methods of treating Alzheimer's disease.
    Type: Application
    Filed: August 1, 2007
    Publication date: July 24, 2008
    Applicants: CoMentis, Inc., The Board of Trustees of the University of Illinois, Oklahoma Medical Research Foundation, Purdue Research Foundation
    Inventors: Arun K. Ghosh, Nagaswamy Kumaragurubaran, Chunfeng Liu, Thippeswamy Devasamudram, Hui Lei, Lisa Swanson, Sudha Ankala, Jordan Tang, Geoffrey Bilcer
  • Beta-secretase inhibitors and methods of use thereof
    Patent number: 7335632
    Abstract: The present invention provides novel beta-secretase inhibitors and methods for their use, including methods of treating of Alzheimer's disease.
    Type: Grant
    Filed: September 17, 2004
    Date of Patent: February 26, 2008
    Assignee: CoMentis, Inc.
    Inventors: Arun K. Ghosh, Hui Lei, Thippeswamy Devasamudram, Chunfeng Liu, Jordan J. N. Tang, Geoffrey Bilcer