Abstract: The invention encompasses formulations and methods for the production thereof that permit the delivery of concentrated protein solutions. The inventive methods can yield a lower viscosity liquid protein formulation or a higher concentration of therapeutic or nontherapeutic proteins in the liquid formulation, as compared to traditional protein solutions. The inventive methods can also yield a higher stability of a liquid protein formulation.
Type:
Grant
Filed:
February 12, 2021
Date of Patent:
November 7, 2023
Assignee:
COMERA LIFE SCIENCES, INC.
Inventors:
David S. Soane, Philip Wuthrich, Rosa Casado Portilla, Robert P. Mahoney, Mark Moody, Daniel G. Greene
Abstract: The invention encompasses formulations and methods for the production thereof that permit the delivery of concentrated protein solutions. The inventive methods can yield a lower viscosity liquid protein formulation or a higher concentration of therapeutic or nontherapeutic proteins in the liquid formulation, as compared to traditional protein solutions. The inventive methods can also yield a higher stability of a liquid protein formulation.
Type:
Grant
Filed:
October 21, 2019
Date of Patent:
July 11, 2023
Assignee:
Comera Life Sciences, Inc.
Inventors:
Philip Wuthrich, Robert P. Mahoney, Subhashchandra Naik, Timothy Tran, Yuhong Zeng
Abstract: The invention encompasses formulations and methods for the production thereof that permit the delivery of concentrated protein solutions. The inventive methods can yield a lower viscosity liquid formulation or a higher concentration of therapeutic or nontherapeutic proteins in the liquid formulation, as compared to traditional protein solutions.
Type:
Grant
Filed:
September 16, 2022
Date of Patent:
June 13, 2023
Assignee:
Comera Life Sciences, Inc.
Inventors:
David S. Soane, Philip Wuthrich, Rosa Casado Portilla, Robert P. Mahoney, Mark Moody
Abstract: The invention encompasses formulations and methods for the production thereof that permit the delivery of concentrated protein solutions. The inventive methods can yield a lower viscosity liquid formulation or a higher concentration of therapeutic or nontherapeutic proteins in the liquid formulation, as compared to traditional protein solutions.
Type:
Grant
Filed:
February 25, 2019
Date of Patent:
May 30, 2023
Assignee:
Comera Life Sciences, Inc.
Inventors:
David S. Soane, Philip Wuthrich, Rosa Casado Portilla, Robert P. Mahoney, Mark Moody
Abstract: Disclosed herein are methods for improving a parameter of a protein-related process comprising providing a viscosity-reducing excipient compound selected from the group consisting of hindered amines, anionic aromatics, functionalized amino acids, oligopeptides, short-chain organic acids, and low molecular weight aliphatic polyacids, and adding a viscosity-reducing amount of the viscosity-reducing excipient compound to a carrier solution for the protein-related process, wherein the carrier solution contains a protein of interest, and carrier solutions comprising a liquid medium in which is dissolved a protein of interest, and a viscosity-reducing excipient, wherein the viscosity of the carrier solution has a lower viscosity that that of a control solution that is substantially similar to the carrier solution except for the presence of the viscosity-reducing excipient.
Type:
Grant
Filed:
February 14, 2018
Date of Patent:
June 14, 2022
Assignee:
Comera Life Sciences, Inc.
Inventors:
David S. Soane, Philip Wuthrich, Robert P. Mahoney, Mark Moody, Daniel G. Greene, Neil L. Schauer