Patents Assigned to Commissariat a l'Energie Atomique (C.E.A.)
  • Octapeptide compounds and therapeutic use thereof
    Patent number: 9040482
    Abstract: The present invention relates to novel octapeptide compounds of general formula (I), R-AA1-cyclo(AA2-Tyr3-D-Trp4-AA5-Val6-Cys7)-Thr8-NH2??(I) As these products have a good affinity for certain sub-types of somatostatin receptors, they are particularly useful for treating the pathological states or diseases in which one (or more) of the somatostatin receptors is (are) involved. The invention also relates to pharmaceutical compositions containing said products and their use for the preparation of a medicament.
    Type: Grant
    Filed: June 21, 2011
    Date of Patent: May 26, 2015
    Assignees: IPSEN PHARMA S.A.S., COMMISSARIAT A L'ENERGIE ATOMIQUE (C.E.A.), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.)
    Inventors: Jean-Christophe Cintrat, Melinda Ligeti, Bernard Rousseau, Franck Artzner, Christophe Tarabout, Marie-Thérèse Paternostre, Nicolas Fay, Roland Cherif-Cheikh, Céline Valery
  • VE-cadherin promoter and its uses
    Patent number: 6524815
    Abstract: The invention relates to the isolation and cloning of the VE-cadherin promoter. It also relates to transformed cells and transgenic animals containing the VE-cadherin promoter. The VE-cadherin promoter of the invention is particularly useful for the tissue-specific expression of a gene of interest in the vascular endothelium.
    Type: Grant
    Filed: August 27, 1999
    Date of Patent: February 25, 2003
    Assignee: Commissariat a l'Energie Atomique-C.E.A.
    Inventors: Philippe Huber, Monique Laurent, Sylvie Gory
  • Chimeric proteins activating polymerase III transcription, use thereof for detecting and analysing protein-protein interactions and genes coding for said proteins
    Patent number: 5905025
    Abstract: Genes coding for chimeric proteins activating polymerase III transcription, the chimeric proteins and the use thereof for detecting and analysing protein-protein interactions are described. The chimeric proteins are obtained by fusing a polypeptide which is a polymerase PolIII transcription promoter with a polypeptide which is a first member of a protein-protein interaction pair.
    Type: Grant
    Filed: November 26, 1997
    Date of Patent: May 18, 1999
    Assignee: Commissariat a l'Energie Atomique-C.E.A.
    Inventors: Marie-Claude Marsolier, Andre Sentenac
  • Enhancer and silencer sequences isolated from the GPIIB promoter
    Patent number: 5565358
    Abstract: An amplifier sequence and a silencer sequence of the GPIIb promoter are disclosed. The amplifier sequence includes sequence domains (I) and (II), and the silencer sequence includes sequence domain (III). The use of these sequences in genetic engineering is also described.
    Type: Grant
    Filed: September 30, 1994
    Date of Patent: October 15, 1996
    Assignees: Commissariat a l'Energie Atomique (C.E.A.), Institut National de la Sante et de la Recherche Medicale (I.N.S.E.R.M.)
    Inventors: G erard Marguerie de Rotrou, Georges Uzan, Marie-H el ene Prandini
  • Process for treating residues from the electrolytic processing of zinc, by recovery of the metals therein
    Patent number: 4054638
    Abstract: A process for the re-utilization of the sulphate residues from the electrolytic treatment of zinc.The residues are digested hot with concentrated HCl in the presence of CaCl.sub.2. PbCl.sub.2 crystallizes on cooling. FeCl.sub.3 is extracted with TBP circulating in the direction of a series of columns and FeCl.sub.3 is extracted in a first column, washed in a second column and re-extracted a third column. The solution which issues is treated with NH.sub.3, resulting in precipitation of the majority of the hydroxides of the metals contained therein, which are subsequently separated, while Ag, Zn and Cu are complexed. Ag is precipitated with (NH.sub.4).sub.2 S.NH.sub.3 is recovered by means of lime. CaCl.sub.2 is re-cycled to the start of the process and Cu and Zn are leached together with the mineral.Application of the process to the recovery of the metals contained in the residues from the digestion of blends.
    Type: Grant
    Filed: September 10, 1976
    Date of Patent: October 18, 1977
    Assignees: Compagnie Royale Asturienne des Mines, Commissariat a l'Energie Atomique (C.E.A.)
    Inventors: Noel Dreulle, Alain Fould, Herve Masson