Abstract: The present invention relates to a nanoemulsion in gel-form comprising a continuous aqueous phase and at least one dispersed oily phase, in which: the aqueous phase comprises: at least one co-surfactant including at least one polyalkoxylated chain consisting of ethylene oxide or ethylene oxide and propylene oxide units, and at least one hydrophilic agent of interest, and the oily phase comprises: at least one amphiphilic lipid, at least one solubilizing lipid consisting in a mixture of saturated fatty acid glycerides including: at least 10% by weight of C12 fatty acids, at least 5% by weight of C14 fatty acids, at least 5% by weight of C16 fatty acids, and at least 5% by weight of C18 fatty acids, at least one lipophilic agent of interest, said hydrophilic and lipophilic agents of interest being independently selected from among: a therapeutic agent, an optical agent selected from among a coloring agent, a chromophore, a fluorophore, and a physical agent selected from among a radioactive isotope and a