Abstract: The invention provides a method of producing a cold compactible metallic powder, the method comprising: providing (i) a first metallic powder comprising large metal particles and (ii) a second metallic powder comprising small metal particles, wherein the d50 particle size of the second metallic powder is less than the d50 particle size of the first metallic powder; combining at least the first metallic powder and the second metallic powder to provide a precursor powder comprising the large metal particles and the small metal particles; and subjecting the precursor powder to an impact blending process to adhere the small metal particles to the large particles, thereby producing a cold compactible metallic powder comprising non-spherical particles, wherein the non-spherical particles comprise one of the large metal particles as a core and a plurality of the small metal particles as protrusions from the core.

Abstract: The embodiments herein provide methods to analyze the in vitro stability of recalcitrant or membrane-bound proteins in simulated gastric fluid (SGF) comprising the proteolytic enzyme, pepsin, and in combination with a novel pepsin-trypsin assay employing state-of-the-art mass spectrometric approaches, such as LC-MS/MS, to monitor the precise degradation products. The extent of protein digestion can be evaluated by the appearance of peptic products and the disappearance of tryptic peptide products (as a proxy for intact protein). The embodiments herein also provide methods for protein quantitation using high-sensitivity LC-MRM-MS quantification. The methods embodied herein are particularly useful in charactering proteins produced in transgenic plants, such as canola genetically engineered to produce long chain omega-3 polyunsaturated fatty acids.

Abstract: A method for processing agent data received from one or more agents traversing an environment for use in a simultaneous localisation and mapping process. The method includes determining a pipeline including a number of nodes, and a node configuration for some of the nodes. Each node relates to a respective data processing task implemented using a respective software module, the nodes being interconnected so as to define a node sequence representing a sequence of data processing tasks. The node and pipeline are then used to load and configure software modules, which are then executed to provide output data from at least one software module as processed agent data, wherein the processed agent data is used in a simultaneous localisation and mapping process.

Abstract: A system for moving an object within an environment, wherein the system includes at least one modular wheel configured to move the object. The modular wheel includes a body configured to be attached to the object, a wheel, a drive configured to rotate the wheel and a controller configured to control the drive. One or more processing devices configured are provided to receive an image stream including a plurality of captured images from each of a plurality of imaging devices, the plurality of imaging devices being configured to capture images of the object within the environment, analyse the images to determine an object location within the environment, generate control instructions at least in part using the determined object location and provide the control instructions to the controller, the controller being responsive to the control instructions to control the drive and thereby move the object.

Abstract: A method of determining a tool path for controlling a printing tool, including step (401) of receiving an input file containing data indicative of a three-dimensional structure to be formed. At step (404) the structure is divided into a plurality of build layers, which are separated in a build direction and each layer extends laterally relative to the build direction. Each layer includes an external contour defining the intersection of the layer with an exterior surface of the three-dimensional structure. Step (405) defines a tool path, which fills the three-dimensional structure, wherein the path includes partially filling one or more higher build layers along the build direction before entirely filling at least one lower build layer. At step (406), a printing tool control algorithm is generated that includes a series of control commands for controlling the printing tool to move along the tool path to form the three-dimensional structure.

Abstract: A method of manufacturing a robotic manipulator including determining desired manipulator properties including a manipulator shape and manipulator jamming properties; using the manipulator jamming properties and a packing computational model to determine a packing element configuration, the packing computational model defining relationships between manipulator jamming properties and different packing element configurations; controlling an additive printing machine based on the packing element configuration and manipulator shape to manufacture the robot manipulator. The robot manipulator includes a flexible outer skin defining a chamber; a connector attached to the outer skin and connected to a fluid pump to allow fluid to be added to or removed from the chamber; filling elements disposed in the chamber according to the packing element configuration.

Abstract: The present disclosure relates generally to nucleic acid constructs comprising a nucleotide sequence comprising one or more pigment producing genes, wherein expression of the nucleotide sequence is under the control of a cotton fibre-specific promoter, and wherein the cotton fibre-specific promoter is capable of driving expression of the nucleotide sequence during two or more fibre development stages, and their use in the production of colour cotton fibre, or for the introduction of one or more pigment producing genes into a cotton plant. The present disclosure further contemplates cotton plants modified to produce cotton fibre, cotton seed, cotton lit, yarn, textiles and associated methods.

Abstract: The invention provides cereal plants having a high level of fructan useful for the production of a range of food, beverage, nutraceutical and pharmaceutical products. The invention provides methods of producing high-fructan products from plants modified to comprise a reduced level of an endogenous polypeptide with starch synthase activity, and products so produced. In some embodiments, plants are modified by introduction of an agent such as a nucleic acid molecule which down regulates endogenous starch synthase II gene expression.

Abstract: The present disclosure relates to a continuous flow process for preparing conducting polymers, for example polyaniline. The continuous flow process can provide a controlled synthesis of a conducting polymer from an emulsion comprising a polymerizable organic monomer and a free radical initiator in flow within a temperature controlled continuous flow reactor comprising at least one mixing element. The present disclosure also relates to the conducting polymers prepared by the continuous flow process.

Abstract: The present invention relates to methods for transfecting cells. In particular, the present invention relates to methods of transfecting primordial germ cells in avians, and to methods of breeding avians with modified traits.

Abstract: The present invention relates to methods for producing isothiocyanate containing products from Brassicaceae material and lactic acid bacteria for use in such methods. The present invention also relates to isothiocyanate containing products from Brassicaceae material produced by such methods.

Abstract: The present disclosure relates to polysiloxanes, processes for preparing polysiloxanes, and hydraulic fluids comprising polysiloxanes. This disclosure also relates to hydraulic fluids comprising one or more polysiloxane compounds and diphosphonate compounds, and to the use of diphosphonate compounds in hydraulic fluids or as additives or components in various compositions, for example to provide fire retardant properties to a fluid or composition. This disclosure also relates to use of the compositions as hydraulic fluids, which may be used in various machines, vehicles and craft, including aircraft.

Abstract: The present invention relates to methods of increasing bromoform production.

Abstract: The present invention relates to processes for transfecting cells. In particular, the present invention relates to processes for using CRISPR to incorporate a polynucleotide into the genome of an avian primordial germ cell (PGC).

Abstract: The disclose relates to adenomas of the colon. More particularly, the present disclosure relates to biomarkers which may be used for the detection of advanced colorectal pre-cancerous adenomas (APA) The detection and measurement of these biomarkers in a biological sample may be used to inform the clinician as to whether further invasive procedures such as polypectomy are required.

Abstract: The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desaturase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids. In particular, the present invention provides ?3 destaurases, ?5 elongases and ?6 desaturases with novel activities. Also provided are methods and DNA constructs for transiently and/or stably transforming cells, particularly plant cells, with multiple genes.

Abstract: The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desaturase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids. In particular, the present invention provides ?3 destaurases, ?5 elongases and ?6 desaturases with novel activities. Also provided are methods and DNA constructs for transiently and/or stably transforming cells, particularly plant cells, with multiple genes.

Abstract: A particle heat exchanger comprising: a housing including an inlet located at the top of the housing, and an outlet located below the inlet, the housing configured to enclose a flow of heat transfer particles which flows downwardly from the inlet to the outlet within the housing; at least one heat transfer tube enclosed in the housing and in contact with the flow of heat transfer particles therein, each heat transfer tube extending substantially parallel to an axis extending between the inlet and outlet of the housing; and at least one divider located between the inlet and outlet of the housing, the at least one heat transfer tube extending through each divider, each divider including at least one opening configured to form at least one flow constriction in the flow of heat transfer particles between the inlet and outlet of the housing.