Patents Assigned to Como Biotech ApS
  • Pregnancy-associated plasma protein-A2 (PAPP-A2) polypeptides
    Patent number: 10392610
    Abstract: The present invention provides pregnancy associated plasma protein A2 (PAPP-A2), its nucleotide and amino acid sequences, antisense molecules to the nucleotide sequences which encode PAPP-A2, expression vectors for the production of purified PAPP-A2, antibodies capable of binding specifically to PAPP-A2, hybridization probes or oligonucleotides for the detection of PAPP-A2-encoding nucleotide sequences, genetically engineered host cells for the expression of PAPP-A2, and methods for screening for pathologies in pregnant and non-pregnant patients. Methods for screening for altered focal proliferation states in pregnant and/or non-pregnant patients, which include detecting levels of PAPP-A2, are also described.
    Type: Grant
    Filed: August 22, 2014
    Date of Patent: August 27, 2019
    Assignee: Como Biotech ApS
    Inventors: Claus Oxvig, Michael Toft Overgaard
  • Pregnancy-associated plasma protein-A2 (PAPP-A2) polynucleotides
    Patent number: 9005949
    Abstract: The present invention provides pregnancy associated plasma protein A2 (PAPP-A2), its nucleotide and amino acid sequences, antisense molecules to the nucleotide sequences which encode PAPP-A2, expression vectors for the production of purified PAPP-A2, antibodies capable of binding specifically to PAPP-A2, hybridization probes or oligonucleotides for the detection of PAPP-A2-encoding nucleotide sequences, genetically engineered host cells for the expression of PAPP-A2, and methods for screening for pathologies in pregnant and non-pregnant patients. Methods for screening for altered focal proliferation states in pregnant and/or non-pregnant patients, which include detecting levels of PAPP-A2, are also described.
    Type: Grant
    Filed: September 24, 2012
    Date of Patent: April 14, 2015
    Assignee: Como Biotech ApS
    Inventors: Claus Oxvig, Michael Toft Overgaard
  • METHOD OF DIAGNOSING A CLINICAL CONDITION BY DETECTION OF A PAPP-A/proMBP COMPLEX
    Publication number: 20110091920
    Abstract: The present invention provides a method of diagnosing Down's syndrome, acute coronary syndrome or pre-eclampsia, or a predisposition to any of them, by a method comprising measuring the level of the human PAPP-A/proMBP complex in a body fluid sample.
    Type: Application
    Filed: October 28, 2010
    Publication date: April 21, 2011
    Applicant: Como Biotech APS
    Inventors: Claus Oxvig, Michael Toft Overgaard
  • Pregnancy-associated plasma protein-A2 (PAPP-A2)
    Patent number: 7083940
    Abstract: The present invention provides nucleotide and amino acid sequences that identify and encode a new protein with homology to pregnancy-associated plasma protein-A (PAPP-A). We denote this protein PAPP-A2. The cDNA encoding PAPP-A2 was derived from human placenta.
    Type: Grant
    Filed: October 22, 2001
    Date of Patent: August 1, 2006
    Assignee: Como Biotech ApS
    Inventors: Claus Oxvig, Michael Toft Overgaard
  • Pregnancy-associated plasma protein-A2 (PAPP-A2)
    Publication number: 20030124529
    Abstract: The present invention provides nucleotide and amino acid sequences that identify and encode a new protein with homology to pregnancy-associated plasma protein-A (PAPP-A). We denote this protein PAPP-A2. The cDNA encoding PAPP-A2 was derived from human placenta.
    Type: Application
    Filed: October 22, 2001
    Publication date: July 3, 2003
    Applicant: Como Biotech ApS
    Inventors: Claus Oxvig, Michael Toft Overgaard