Abstract: A multiple-pouch package includes a first pouch wherein is fixed a support impregnated with a substance to be applied on the skin and at least a pouch containing a protection for the skin zone treated with the applied substance. The protection can consist of an adhesive plaster, a bandage, a compress or a dressing. Rupture-proof devices are provided to prevent the two walls of a common pouch to be entirely separated when it is opened. Opening facilitators are provided to facilitate the opening of the different pouches. The multiple-pouch package can be produced by fixing the different single pouches one to the other or by folding on itself one strip to form the various pouches.