Patents Assigned to Compagnie Oris Industrie
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Patent number: 5534622Abstract: The invention relates to rare earth cryptates consisting of at least one rare earth salt complexed by a macropolycyclic compound corresponding to one of formulae I or II below, in which:the ring ##STR1## is the N.sub.2 O.sub.4 macrocycle, the N.sub.2 O.sub.3 macrocycle or the bis--bipyridine macrocycle;Y is a spacer arm or group which consists of a divalent organic radical selected from linear or branched C.sub.1 to C.sub.20 alkylene groups optionally containing one or more double bonds and/or optionally being interrupted by one or more heteroatoms such as oxygen, nitrogen, sulfur or phosphorus, or from C.sub.5 to C.sub.8 cycloalkylene groups or C.sub.6 to C.sub.14 arylene groups, the said alkylene or arylene groups optionally being substituted by alkyl, aryl or sulfonate groups;Z is a functional group capable of bonding covalently with a biological substance;R is a methyl group or represents the group --Y--Z; andR' is hydrogen or a group --COOR", in which R" is a C.sub.1 to C.sub.Type: GrantFiled: June 5, 1995Date of Patent: July 9, 1996Assignee: Compagnie Oris Industrie, SAInventors: Jean-Marie Lehn, Gerard Mathis, Beatrice Alpha, Robert Deschenaux, Etienne Jolu
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Patent number: 5457185Abstract: The invention relates to rare earth cryptates consisting of at least one rare earth salt complexed by a macropolycyclic compound corresponding to one of formulae I or II below, in which:the ring ##STR1## is the N.sub.2 O.sub.4 macrocycle, the N.sub.2 O.sub.3 macrocycle or the bis-bipyridine macrocycle;Y is a spacer arm or group which consists of a divalent organic radical selected from linear or branched C.sub.1 to C.sub.20 alkylene groups optionally containing one or more double bonds and/or optionally being interrupted by one or more heteroatoms such as oxygen, nitrogen, sulfur or phosphorus, or from C.sub.5 to C.sub.8 cycloalkylene groups or C.sub.6 to C.sub.14 arylene groups, the said alkylene or arylene groups optionally being substituted by alkyl, aryl or sulfonate groups;Z is a functional group capable of bonding covalently with a biological substance;R is a methyl group or represents the group --Y--Z; andR' is hydrogen or a group --COOR", in which R" is a C.sub.1 to C.sub.Type: GrantFiled: June 9, 1994Date of Patent: October 10, 1995Assignee: Societe Anonyme: Compagnie Oris IndustrieInventors: Jean-Marie Lehn, Geatrice Mathis, Beatrice Alpha, Robert Deschenaux, Etienne Jolu
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Patent number: 5432101Abstract: The invention relates to macropolycyclic rare earth complexes, namely cryptates which are useful as fluorescent tracers.Type: GrantFiled: December 17, 1992Date of Patent: July 11, 1995Assignee: Compagnie Oris Industrie SAInventors: Gerard Mathis, Jean-Marie Lehn
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Patent number: 5346996Abstract: The invention relates to rare earth cryptates consisting of at least one rare earth salt complexed by a macropolycyclic compound corresponding to one of formulae I or II below, in which:the ring ##STR1## is the N.sub.2 O.sub.4 macrocycle, the N.sub.2 O.sub.3 macrocycle or the bis-bipyridine macrocycle;Y is a spacer arm or group which consists of a divalent organic radical selected from linear or branched C.sub.1 to C.sub.20 alkylene groups optionally containing one or more double bonds and/or optionally being interrupted by one or more heteroatoms such as oxygen, nitrogen, sulfur or phosphorus, or from C.sub.5 to C.sub.8 cycloalkylene groups or C.sub.6 to C.sub.14 arylene groups, the said alkylene or arylene groups optionally being substituted by alkyl, aryl or sulfonate groups;Z is a functional group capable of bonding covalently with a biological substance;R is a methyl group or represents the group --Y--Z; andR' is hydrogen or a group --COOR", in which R" is a C.sub.1 to C.sub.Type: GrantFiled: September 14, 1992Date of Patent: September 13, 1994Assignee: Compagnie Oris IndustrieInventors: Jean-Marie Lehn, Gerard Mathis, Beatrice Alpha, Robert Deschenaux, Etienne Jolu
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Patent number: 5279943Abstract: The present invention relates to a homogeneous process for the detection and/or determination of an analyte in a medium in which it may be present, by disclosing the reaction product of the analyte and a corresponding receptor, process consisting in: 1) adding to said medium a first reagent consisting of a receptor for the said analyte; 2) adding a second reagent consisting of at least one of the components of the reaction product of the analyte and at least one of its receptors; one of the two reagents being coupled with a luminescent compound and the other reagent possessing a heavy atom or units containing a heavy atom; 3) incubating the medium after addition of each reagent or after the addition of both reagents; 4) exciting the resulting medium and 5) measuring at equilibrium or during the kinetics, the signal emitted by the luminescent compound, said signal being modulated by the heavy atom effect.Type: GrantFiled: January 19, 1993Date of Patent: January 18, 1994Assignee: Compagnie Oris IndustrieInventors: Gerard Mathis, Thierry Davin
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Patent number: 5220012Abstract: The invention relates to macropolycyclic rare earth complexes, namely cryptates which are useful as fluorescent tracers.Type: GrantFiled: March 5, 1990Date of Patent: June 15, 1993Assignee: Compagnie Oris Industrie SAInventors: Gerard Mathis, Jean-Marie Lehn
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Patent number: 5217905Abstract: A device for the rapid qualitative and quantitative determination of the presence of a reactive ligand in a fluid.This device comprises a first reaction zone in which there is an at least temporarily impermeable membrane designed to receive a sample of test fluid and to be associated with at least one labeled reagent; a second reaction zone which is bounded on the one hand by the said membrane and on the other by a second at least temporarily impermeable membrane comprising a solid phase containing a reference reagent; and a third reaction zone which contains means for developing the reaction.A method for the rapid qualitative and quantitative determination of the presence of a reactive ligand in a fluid.Applications to the detection of the presence, in a biological fluid, of antibodies or antigens in particular.Type: GrantFiled: July 18, 1988Date of Patent: June 8, 1993Assignees: Compagnie Oris Industrie S.A., CistestInventors: Joseph Marchand, Jacques Toledano
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Patent number: 5162508Abstract: The invention relates to rare earth cryptates consisting of at least one rare earth salt complexed by a macropolycyclic compound corresponding to one of formulae I or II below, in which:the ring ##STR1## is the N.sub.2 O.sub.4 macrocycle, the N.sub.2 O.sub.3 macrocycle or a bis-bipyridine macrocycle;Y is a spacer arm or group which consists of a divalent organic radical selected from linear or branched C.sub.1 to C.sub.20 alkylene groups optionally containing one or more double bonds and/or optionally being interrupted by one or more heteroatoms such as oxygen, nitrogen, sulfur or phosphorus, or from C.sub.5 to C.sub.8 cycloalkylene groups or C.sub.6 to C.sub.Type: GrantFiled: July 26, 1991Date of Patent: November 10, 1992Assignee: Compagnie Oris IndustrieInventors: Jean-Marie Lehn, Mathis Gerard, Beatrice Alpha, Robert Deschenaux, Etienne Jolu
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Patent number: 5010017Abstract: The invention relates to a process for the immunological quantitative determination of the T.sub.3 and/or T.sub.4 thyroid hormones.In a process for the immunological quantitative determination of T.sub.4 thyroxine and/or T.sub.3 triiodothyronine present in free form in a sample, T.sub.3 and/or T.sub.4 to be determined are put into competition with thyroglobulin for the sites of anti-T.sub.3 and/or anti-T.sub.4 antibodies present in a limited quantity, whereafter a determination is made of either the quantity of thyroglobulin fixed to the anti-T.sub.3 and/or anti-T.sub.4 antibodies, or the quantity of thyroglobulin not fixed to the anti-T.sub.3 and/or anti-T.sub.4 antibodies.Application to the determination of the total T.sub.3 and/or T.sub.4 of a biological sample.Type: GrantFiled: August 17, 1990Date of Patent: April 23, 1991Assignee: Compagnie Oris Industrie S.A.Inventors: Bernard Ferrua, Claude Moulin
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Patent number: 4966838Abstract: The invention relates to a process for the immunological quantitative determination of the T.sub.3 and/or T.sub.4 thyroid hormones.In a process for the immunological quantitative determination of T.sub.4 thyroxine and/or T.sub.3 triiodothyronine present in free form in a sample, T.sub.3 and/or T.sub.4 to be determined are put into completion with thyroglobulin for the sites of anti-T.sub.3 and/or anti-T.sub.4 antibodies present in a limited quantity, whereafter a determination is made of either the quantity of thyroglobulin fixed to the anti-T.sub.3 and/or anti-T.sub.4 antibodies, or the quantity of thyroglobulin not fixed to the anti-T.sub.3 and/or anbti-T.sub.4 antibodies.Type: GrantFiled: May 11, 1987Date of Patent: October 30, 1990Assignee: Compagnie Oris Industrie S.A.Inventors: Bernard Ferrua, Claude Moulin
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Patent number: 4925937Abstract: The present invention relates to a process for the photocleavage of nucleic acids which consists in bringing a nucleic acid into contact with a solution of a 2,7-diazapyrene derivative and in subjecting the resulting reaction mixture to irradiation with visible light.Type: GrantFiled: December 15, 1987Date of Patent: May 15, 1990Assignee: Compagnie Oris IndustrieInventors: Jean M. Lehn, Jaroslaw Jazwinski, John Blacker
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Patent number: 4888019Abstract: A polymer articular prosthesis having a sliding surface, wherein the latter is constituted by a thin layer of said polymer grafted with tetrafluoro-ethylene.The process for preparing the articular prosthesis comprises coating with a protective varnish the outer surface of a polymer articular prosthesis having a sliding surface, except in the areas constituting this sliding surface irradiating the prosthesis with ionizing rays, contacting the prosthesis with the tetrafluoroethylene vapour for adequate time to bring about tetrafluoroethylene grafting over a limited thickness of the polymer forming the sliding surface and then removing the protective varnish.Type: GrantFiled: September 9, 1982Date of Patent: December 19, 1989Assignee: Compagnie Oris Industrie S.A.Inventors: Gilbert Gauneus, Maryvonne Nicaise, Kifu O. Tran
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Patent number: 4729904Abstract: Inert cross-linked copolymer able to absorb and then progressively release a pharmaceutically active substance, wherein it is constituted by a powder of a cross-linked copolymer comprising30 to 80% by weight of monounsaturated alkyl acrylate and/or methacrylate;5 to 68% by weight of acrylic and/or methacrylic acid; and2 to 15% by weight of bifunctional or trifunctional acrylate and/or methacrylate.A mixture of monounsaturated alkyl acrylate and/or methacrylate, acrylic and/or methacrylic acid, and bifunctional or trifunctional acrylate and/or methacrylate monomers is polymerized in accordance with a free radical polymerization mechanism.The support is used for the preparation of a delayed action or release medicament.Type: GrantFiled: August 7, 1985Date of Patent: March 8, 1988Assignee: Compagnie ORIS Industrie S.A.Inventors: Jeanne Berthet, Marie-Francoise Blin, Gilbert Gaussens
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Patent number: 4590068Abstract: Inert cross-linked copolymer able to absorb and then progressively release a pharmaceutically active substance, wherein it is constituted by a powder of a cross-linked copolymer comprising30 to 80% by weight of monounsaturated alkyl acrylate and/or methacrylate;5 to 68% by weight of acrylic and/or methacrylic acid; and2 to 15% by weight of bifunctional or trifunctional acrylate and/or methacrylate polymerized in accordance with free radical polymerization mechanisms.Type: GrantFiled: August 22, 1983Date of Patent: May 20, 1986Assignee: Compagnie ORIS Industrie S.A.Inventors: Jeanne Berthet, Marie-Francoise Blin, Gilbert Gaussens