Abstract: The disclosure provides methods for treating a subject in need thereof comprising administering to the subject a therapeutically-effective dose of psilocybin. The methods described herein may be used to treat a variety of diseases, disorders, and conditions. For example, the methods may be used to treat anxiety disorders, eating disorders, and headache disorders.
Type:
Application
Filed:
March 17, 2026
Publication date:
July 23, 2026
Applicant:
Compass Pathfinder Limited
Inventors:
Derek John LONDESBROUGH, Christopher BROWN, Julian Scott NORTHEN, Gillian MOORE, David E. NICHOLS, Hans Åke ERIKSSON, George GOLDSMITH, Ekaterina MALIEVSKAIA, Manon Cecile Elisabeth VERAART, Lars Christian WILDE
Abstract: This invention relates to the large-scale production of psilocybin for use in medicine. More particularly, it relates to a method of obtaining high purity crystalline psilocybin, particularly, in the form of Polymorph A. It further relates to a method for the manufacture of psilocybin and intermediates in the production thereof and formulations containing psilocybin.
Type:
Grant
Filed:
August 11, 2025
Date of Patent:
June 30, 2026
Assignee:
Compass Pathfinder Limited
Inventors:
Derek John Londesbrough, Christopher Brown, Julian Scott Northen, Gillian Moore, David E. Nichols
Abstract: This invention relates to the large-scale production of psilocybin for use in medicine. More particularly, it relates to a method of obtaining high purity crystalline psilocybin, particularly, in the form of Polymorph A. It further relates to a method for the manufacture of psilocybin and intermediates in the production thereof and formulations containing psilocybin.
Type:
Grant
Filed:
August 11, 2025
Date of Patent:
June 23, 2026
Assignee:
Compass Pathfinder Limited
Inventors:
Derek John Londesbrough, Christopher Brown, Julian Scott Northen, Gillian Moore, David E. Nichols
Abstract: This invention relates to the large-scale production of psilocybin for use in medicine. More particularly, it relates to a method of obtaining high purity crystalline psilocybin, particularly, in the form of Polymorph A. It further relates to a method for the manufacture of psilocybin and intermediates in the production thereof and formulations containing psilocybin.
Type:
Application
Filed:
August 11, 2025
Publication date:
June 11, 2026
Applicant:
Compass Pathfinder Limited
Inventors:
Derek John LONDESBROUGH, Christopher BROWN, Julian Scott NORTHEN, Gillian MOORE, David E. NICHOLS
Abstract: This invention relates to the large-scale production of psilocybin for use in medicine. More particularly, it relates to a method of obtaining high purity crystalline psilocybin, particularly, in the form of Polymorph A. It further relates to a method for the manufacture of psilocybin and intermediates in the production thereof and formulations containing psilocybin.
Type:
Grant
Filed:
June 12, 2025
Date of Patent:
June 2, 2026
Assignee:
Compass Pathfinder Limited
Inventors:
Derek John Londesbrough, Christopher Brown, Julian Scott Northen, Gillian Moore, David E. Nichols
Abstract: The disclosure provides methods for treating a subject in need thereof comprising administering to the subject a therapeutically-effective dose of psilocybin. The methods described herein may be used to treat a variety of diseases, disorders, and conditions. For example, the methods may be used to treat anxiety disorders, eating disorders, and headache disorders.
Type:
Grant
Filed:
August 11, 2025
Date of Patent:
April 28, 2026
Assignee:
Compass Pathfinder Limited
Inventors:
Derek John Londesbrough, Christopher Brown, Julian Scott Northen, Gillian Moore, David E. Nichols, Hans Åke Eriksson, George Goldsmith, Ekaterina Malievskaia, Manon Cecile Elisabeth Veraart, Lars Christian Wilde
Abstract: Disclosed herein are prokaryotic and eukaryotic microbes, including E. coli and S. cerevisiae, genetically altered to biosynthesize tryptamine and tryptamine derivatives. The microbes of the disclosure may be engineered to contain plasmids and stable gene integrations containing sufficient genetic information for conversion of an anthranilate or an indole to a tryptamine. The fermentative production of substituted tryptamines in a whole-cell biocatalyst may be useful for cost effective production of these compounds for therapeutic use.
Abstract: This invention relates to the large-scale production of psilocybin for use in medicine. More particularly, it relates to a method of obtaining high purity crystalline psilocybin, particularly, in the form of Polymorph A. It further relates to a method for the manufacture of psilocybin and intermediates in the production thereof and formulations containing psilocybin.
Type:
Application
Filed:
August 11, 2025
Publication date:
December 4, 2025
Applicant:
Compass Pathfinder Limited
Inventors:
Derek John LONDESBROUGH, Christopher BROWN, Julian Scott NORTHEN, Gillian MOORE, Hemant Kashinath PATIL, David E. NICHOLS
Abstract: The disclosure provides methods for treating a subject in need thereof comprising administering to the subject a therapeutically-effective dose of psilocybin. The methods described herein may be used to treat a variety of diseases, disorders, and conditions. For example, the methods may be used to treat anxiety disorders, eating disorders, and headache disorders.
Type:
Application
Filed:
August 11, 2025
Publication date:
December 4, 2025
Applicant:
Compass Pathfinder Limited
Inventors:
Derek John LONDESBROUGH, Christopher BROWN, Julian Scott NORTHEN, Gillian MOORE, Hemant Kashinath PATIL, David E. NICHOLS, Hans Åke ERIKSSON, George GOLDSMITH, Ekaterina MALIEVSKAIA, Manon Cecile Elisabeth VERAART, Lars Christian WILDE
Abstract: This invention relates to the large-scale production of psilocybin for use in medicine. More particularly, it relates to a method of obtaining high purity crystalline psilocybin, particularly, in the form of Polymorph A. It further relates to a method for the manufacture of psilocybin and intermediates in the production thereof and formulations containing psilocybin.
Type:
Application
Filed:
August 11, 2025
Publication date:
November 27, 2025
Applicant:
Compass Pathfinder Limited
Inventors:
Derek John LONDESBROUGH, Christopher BROWN, Julian Scott NORTHEN, Gillian MOORE, Hemant Kashinath PATIL, David E. NICHOLS
Abstract: This invention relates to the large-scale production of psilocybin for use in medicine. More particularly, it relates to a method of obtaining high purity crystalline psilocybin, particularly, in the form of Polymorph A. It further relates to a method for the manufacture of psilocybin and intermediates in the production thereof and formulations containing psilocybin.
Type:
Grant
Filed:
December 20, 2024
Date of Patent:
November 4, 2025
Assignee:
Compass Pathfinder Limited
Inventors:
Derek John Londesbrough, Christopher Brown, Julian Scott Northen, Gillian Moore, Hemant Kashinath Patil, David E. Nichols
Abstract: The disclosure provides methods for treating a subject in need thereof comprising administering to the subject a therapeutically-effective dose of psilocybin. The methods described herein may be used to treat a variety of diseases, disorders, and conditions. For example, the methods may be used to treat anxiety disorders, eating disorders, and headache disorders.
Type:
Grant
Filed:
November 29, 2023
Date of Patent:
October 21, 2025
Assignee:
Compass Pathfinder Limited
Inventors:
Derek John Londesbrough, Christopher Brown, Julian Scott Northen, Gillian Moore, Hemant Kashinath Patil, David E. Nichols, Hans Åke Eriksson, George Goldsmith, Ekaterina Malievskaia, Manon Cecile Elisabeth Veraart, Lars Christian Wilde
Abstract: The disclosure provides methods for treating a subject in need thereof comprising administering to the subject a therapeutically-effective dose of psilocybin. The methods described herein may be used to treat a variety of diseases, disorders, and conditions. For example, the methods may be used to treat anxiety disorders, eating disorders, and headache disorders.
Type:
Grant
Filed:
April 17, 2020
Date of Patent:
October 7, 2025
Assignee:
Compass Pathfinder Limited
Inventors:
Derek John Londesbrough, Christopher Brown, Julian Scott Northen, Gillian Moore, Hemant Kashinath Patil, David E. Nichols, Hans Ake Eriksson, George Goldsmith, Ekaterina Malievskaia, Manon Cecile Elisabeth Veraart, Lars Christian Wilde
Abstract: The disclosure provides methods for treating a subject in need thereof comprising administering to the subject a therapeutically-effective dose of psilocybin. The methods described herein may be used to treat a variety of diseases, disorders, and conditions. For example, the methods may be used to treat neurocognitive disorders (e.g., Alzheimer's disease, Parkinson's disease), ADHD, Epilepsy, Autism, Sleep-wake disorders, Chronic pain, Inflammatory Disorders, IBD, Stroke, ALS, and/or Multiple Sclerosis.
Type:
Application
Filed:
June 11, 2025
Publication date:
October 2, 2025
Applicant:
Compass Pathfinder Limited
Inventors:
Derek John LONDESBROUGH, Christopher BROWN, Julian Scott NORTHEN, Gillian MOORE, Hemant Kashinath PATIL, David E. NICHOLS, Hans Åke ERIKSSON, George GOLDSMITH, Ekaterina MALIEVSKAIA, Manon Cecile Elisabeth VERAART, Tobias Patrick WHELAN, Lars Christian WILDE
Abstract: This invention relates to the large-scale production of psilocybin for use in medicine. More particularly, it relates to a method of obtaining high purity crystalline psilocybin, particularly, in the form of Polymorph A. It further relates to a method for the manufacture of psilocybin and intermediates in the production thereof and formulations containing psilocybin.
Type:
Application
Filed:
June 12, 2025
Publication date:
October 2, 2025
Applicant:
Compass Pathfinder Limited
Inventors:
Derek John LONDESBROUGH, Christopher BROWN, Julian Scott NORTHEN, Gillian MOORE, Hemant Kashinath PATIL, David E. NICHOLS
Abstract: The disclosure provides methods for treating a subject in need thereof comprising administering to the subject a therapeutically-effective dose of psilocybin. The methods described herein may be used to treat a variety of diseases, disorders, and conditions. For example, the methods may be used to treat neurocognitive disorders (e.g., Alzheimer's disease, Parkinson's disease), ADHD, Epilepsy, Autism, Sleep-wake disorders, Chronic pain, Inflammatory Disorders, IBD, Stroke, ALS, and/or Multiple Sclerosis.
Type:
Grant
Filed:
April 17, 2020
Date of Patent:
August 5, 2025
Assignee:
Compass Pathfinder Limited
Inventors:
Derek John Londesbrough, Christopher Brown, Julian Scott Northen, Gillian Moore, Hemant Kashinath Patil, David E. Nichols, Hans Ake Eriksson, George Goldsmith, Ekaterina Malievskaia, Manon Cecile Elisabeth Veraart, Tobias Patrick Whelan, Lars Christian Wilde
Abstract: This invention relates to the large-scale production of psilocybin for use in medicine. More particularly, it relates to a method of obtaining high purity crystalline psilocybin, particularly, in the form of Polymorph A. It further relates to a method for the manufacture of psilocybin and intermediates in the production thereof and formulations containing psilocybin.
Type:
Grant
Filed:
July 9, 2024
Date of Patent:
May 27, 2025
Assignee:
Compass Pathfinder Limited
Inventors:
Derek John Londesbrough, Christopher Brown, Julian Scott Northen, Gillian Moore, Hemant Kashinath Patil, David E. Nichols
Abstract: This invention relates to the large-scale production of psilocybin for use in medicine. More particularly, it relates to a method of obtaining high purity crystalline psilocybin, particularly, in the form of Polymorph A. It further relates to a method for the manufacture of psilocybin and intermediates in the production thereof and formulations containing psilocybin.
Type:
Application
Filed:
December 20, 2024
Publication date:
April 17, 2025
Applicant:
Compass Pathfinder Limited
Inventors:
Derek John LONDESBROUGH, Christopher BROWN, Julian Scott NORTHEN, Gillian MOORE, Hemant Kashinath PATIL, David E. NICHOLS
Abstract: The disclosure provides methods for treating treatment-resistant depression a subject in need thereof comprising administering to the subject two or more doses of psilocybin.
Type:
Application
Filed:
November 2, 2022
Publication date:
January 2, 2025
Applicant:
COMPASS PATHFINDER LIMITED
Inventors:
Trevor Anthony MILL, Guy Manning GOODWIN, Joyce TSAI, Lindsey MARWOOD, Sunil MISTRY
Abstract: This invention relates to the large-scale production of psilocybin for use in medicine. More particularly, it relates to a method of obtaining high purity crystalline psilocybin, particularly, in the form of Polymorph A. It further relates to a method for the manufacture of psilocybin and intermediates in the production thereof and formulations containing psilocybin.
Type:
Application
Filed:
July 9, 2024
Publication date:
October 31, 2024
Applicant:
Compass Pathfinder Limited
Inventors:
Derek John LONDESBROUGH, Christopher BROWN, Julian Scott NORTHEN, Gillian MOORE, Hemant Kashinath PATIL, David E. NICHOLS