Abstract: Methods are provided for carrying out DNA sequencing on a device having upper and lower conductive layers separated by an insulative layer. Holes in the upper conductive layer create discrete attachment sites for DNA fragments. Voltage is applied to the surface to control affinity between the attachment sites and the DNA fragments, and to compact the DNA fragments for discrete optical detection.
Type:
Grant
Filed:
December 27, 2011
Date of Patent:
January 24, 2017
Assignee:
Complete Genomincs, Inc.
Inventors:
Andres Fernandez, Bryan Staker, Radoje Drmanac