Abstract: A method and system are disclosed for providing an aggregated trained machine learning model for performing a prediction task. A main processing device obtains from a first processing device at least a portion of a first trained model having been generated by training an initial model on a first training dataset, and a first training parameter indicative of a level of predictive uncertainty thereof. The main processing device obtains from a second processing device at least a portion of a second trained model having been generated by training the initial model on a second training dataset, and a second training parameter indicative of a level of predictive uncertainty thereof. The main processing device combines, using the first and second training parameters, at least the portion of the first and second trained models to thereby obtain the aggregated trained model. The main processing device provides the aggregated trained model.

Abstract: Compositions and pharmaceutical compositions including a dendrimer-resveratrol complex and methods for making and using the compositions are described herein. Methods of treating cancer, cardiovascular disease, cardiac failure, diabetes, Alzheimer's disease, Parkinson's disease and other brain diseases, fatty liver disease, obesity, cataracts, osteoporosis, muscle wasting, sleep disorders, acoustic trauma, inflammatory disease, psoriasis, arthritis, colitis, aging, viral disease, reproductive disease, and skin conditions or disorders including administering a therapeutically effective amount of the compositions to a subject in need are also provided. The compositions may be topically applied to skin or mucous membranes.

Abstract: A formation method is provided. During this formation method, a metallic substrate is provided. A coating is deposited onto the metallic substrate using a suspension plasma spray process. The coating is formed from or otherwise includes copper oxide.

Abstract: Disclosed are methods and compositions which may be used in human cytochrome P450 (CYP450) enzyme phenotyping. The methods and compositions typically utilize substrate for CYP3A5 comprising eplerenone which may be administered orally to a subject. Subsequently, metabolites of eplereone may be detected in the subject's saliva as well as any non- metabolized eplerenone to calculate a metabolic ratio for CYP3A5 enzyme in order to generate a phenytopic CYP3A5 enzyme profile for the subject.

Abstract: Navigation of a virtual environment (VE) can mean navigating a VE that is spatially larger than the available Physical Tracked Space (PTS). Accordingly, the concept of redirected walking was introduced in order to provide a more natural way of navigating a VE, albeit with many restrictions on the shape and size of the physical and virtual spaces. However, prior art techniques have limitations such as negatively impacting the sense of immersion of the user, motion sickness, or forcing the user to look away by stimulating major saccades. Accordingly, the inventors have established a novel technique which overcomes these limitations. The technique is based on the psychological phenomenon of inattentional blindness allowing for re-directed walking without requiring the triggering major saccades in the users, complex expensive systems, etc.

Abstract: Compositions and pharmaceutical compositions including a dendrimer-resveratrol complex and methods for making and using the compositions are described herein. Methods of treating cancer, cardiovascular disease, cardiac failure, diabetes, Alzheimer's disease, Parkinson's disease and other brain diseases, fatty liver disease, obesity, cataracts, osteoporosis, muscle wasting, sleep disorders, acoustic trauma, inflammatory disease, psoriasis, arthritis, colitis, aging, viral disease, reproductive disease, and skin conditions or disorders including administering a therapeutically effective amount of the compositions to a subject in need are also provided. The compositions may be topically applied to skin or mucous membranes.

Abstract: Disclosed are methods and compositions which may be used in human cytochrome P450 (CYP450) enzyme phenotyping. The methods and compositions typically utilize a mélange of substrates for different CYP450 enzymes which may be administered orally to a patient. Subsequently, the metabolites of the substrates may be detected in the patient's saliva as well as any non-metabolized substrates to calculate a metabolic ratio for any given CYP450 enzyme in order to generate a phenotypic CYP450 enzyme profile for the patient.

Abstract: Disclosed are substituted (4?-hydroxylphenyl)cycloalkane compounds and there use as selective agonists of the estrogen receptor beta isoform (ER?). The disclosed compounds may be formulated as pharmaceutical compositions and administered to treat diseases associated with ER activity, such as proliferative diseases and disorders and/or psychiatric diseases or disorders.

Abstract: Compositions and pharmaceutical compositions including a dendrimer-resveratrol complex and methods for making and using the compositions are described herein. Methods of treating cancer, cardiovascular disease, cardiac failure, diabetes, Alzheimer's disease, Parkinson's disease and other brain diseases, fatty liver disease, obesity, cataracts, osteoporosis, muscle wasting, sleep disorders, acoustic trauma, inflammatory disease, psoriasis, arthritis, colitis, aging, viral disease, reproductive disease, and skin conditions or disorders including administering a therapeutically effective amount of the compositions to a subject in need are also provided. The compositions may be topically applied to skin or mucous membranes.

Abstract: Disclosed are methods and compositions which may be used in human cytochrome P450 (CYP450) enzyme phenotyping. The methods and compositions typically utilize a mélange of substrates for different CYP450 enzymes which may be administered orally to a patient. Subsequently, the metabolites of the substrates may be detected in the patient's saliva as well as any non-metabolized substrates to calculate a metabolic ratio for any given CYP450 enzyme in order to generate a phenotypic CYP450 enzyme profile for the patient.

Abstract: In order to implement a microfluidics sensor having higher efficiency, Applicants have developed a method of formation of nano-structures having various shapes and sizes onto materials such as polymers, glass and silicon, which are compatible with the microfabrication processes. The adhesion of the nano-structures and feasibility to tune their properties (optical, electrical and mechanical) are two prime concerns when they are adopted for microfluidics devices.

Abstract: Compositions and pharmaceutical compositions including a dendrimer-resveratrol complex and methods for making and using the compositions are described herein. Methods of treating cancer, cardiovascular disease, cardiac failure, diabetes, Alzheimer's disease, Parkinson's disease and other brain diseases, fatty liver disease, obesity, cataracts, osteoporosis, muscle wasting, sleep disorders, acoustic trauma, inflammatory disease, psoriasis, arthritis, colitis, aging, viral disease, reproductive disease, and skin conditions or disorders including administering a therapeutically effective amount of the compositions to a subject in need are also provided. The compositions may be topically applied to skin or mucous membranes.

Abstract: Disclosed are substituted (4?-hydroxylphenyl)cycloalkane compounds and there use as selective agonists of the estrogen receptor beta isoform (ER?). The disclosed compounds may be formulated as pharmaceutical compositions and administered to treat diseases associated with ER activity, such as proliferative diseases and disorders and/or psychiatric diseases or disorders.

Abstract: An electrically conductive adhesive sheet for joining structural elements, the adhesive sheet comprising Bucky paper impregnated with an adhesive resin is provided. A method of forming an electrically conductive joint between structural elements and a process of making an electrically conductive adhesive sheet for joining structural elements are also provided.

Abstract: In order to implement a microfluidics sensor having higher efficiency, Applicants have developed a method of formation of nano-structures having various shapes and sizes onto materials such as polymers, glass and silicon, which are compatible with the microfabrication processes. The adhesion of the nano-structures and feasibility to tune their properties (optical, electrical and mechanical) are two prime concerns when they are adopted for microfluidics devices.

Abstract: The present application is directed to a technological platform with integrated microfluidic and optical modules for bio-detection. The platform enables in-situ detection by integrating fluidics with optical source and detection capabilities within a fabricated microchip. The platform is a polymer-based microfluidic chip having integrated excitation source and detection elements in a vicinity of a microfluidic reaction chamber configured to contain a micro-volume of a test sample. The principle of detection is based on an excitation source induced fluorescence of the test sample within the microfluidic reaction chamber.

Abstract: A device, a method of fabricating the device and a sample analysis system that includes the device are provided. The device includes an optical waveguide having a plurality of nanofeatures integrated thereon to influence at least one of evanescence and coupling of an optical field of the optical waveguide. The sample analysis system includes a fluidic actuation system for introducing sample specimen fluid into a microfluidic channel of the device for evanescence based detection.

Abstract: A sensing element for sensing the softness of an object by abutting the sensing element against the object and biasing the sensing element toward the object with a biasing force. The sensing element includes a deformable section, the deformable section being deformable between an undeformed configuration and a deformed configuration, the deformed configuration being achievable when the deformable section is abutted against and biased toward the object; a deformation sensor operatively coupled to the deformable section for sensing a deformation of the deformable section between the deformed and undeformed configurations; and a force sensor operatively coupled to the deformable section for sensing the biasing force exerted onto the deformable section by the object when the deformable section is biased toward the object with the biasing force.

Abstract: The invention provides a fast method for a high-quality interpolation of a finite multidimensional dataset. It has particular application in digital image processing, including, but not limited to, processing of both still images and real-time image/data processing. The method uses discrete cosine and sine transforms of appropriate types to covert, in blocks of desired size, the initial dataset to the frequency domain. Proposed interpolators calculate a chain of inverse transforms of non-square sizes that perform the interpolation. The larger transform is broken into smaller transforms of non-square size using a recursive size reduction process of FFT-type, and the smaller transforms are calculated directly exploiting the symmetry properties of smaller interpolator functions involved. An output dataset is then assembled using the calculated transforms. The method avoids computationally costly process of inflating the coefficient space by padding zeros exploited for DCT-based interpolations previously.

Abstract: An electrically conductive adhesive sheet for joining structural elements, the adhesive sheet comprising Bucky paper impregnated with an adhesive resin is provided. A method of forming an electrically conductive joint between structural elements and a process of making an electrically conductive adhesive sheet for joining structural elements are also provided.