Patents Assigned to Concordia University, Inc.
  • Eplerenone for phenotyping of CYP3A5 enzyme activity in saliva samples
    Patent number: 11747352
    Abstract: Disclosed are methods and compositions which may be used in human cytochrome P450 (CYP450) enzyme phenotyping. The methods and compositions typically utilize substrate for CYP3A5 comprising eplerenone which may be administered orally to a subject. Subsequently, metabolites of eplereone may be detected in the subject's saliva as well as any non- metabolized eplerenone to calculate a metabolic ratio for CYP3A5 enzyme in order to generate a phenytopic CYP3A5 enzyme profile for the subject.
    Type: Grant
    Filed: August 7, 2018
    Date of Patent: September 5, 2023
    Assignee: Concordia University, Inc.
    Inventors: Joseph McGraw, Armin Gerhardt
  • Compositions for CYP450 phenotyping using saliva samples
    Patent number: 10927398
    Abstract: Disclosed are methods and compositions which may be used in human cytochrome P450 (CYP450) enzyme phenotyping. The methods and compositions typically utilize a mélange of substrates for different CYP450 enzymes which may be administered orally to a patient. Subsequently, the metabolites of the substrates may be detected in the patient's saliva as well as any non-metabolized substrates to calculate a metabolic ratio for any given CYP450 enzyme in order to generate a phenotypic CYP450 enzyme profile for the patient.
    Type: Grant
    Filed: November 30, 2016
    Date of Patent: February 23, 2021
    Assignee: Concordia University Inc.
    Inventors: Joseph McGraw, Armin Gerhardt
  • Substituted (4'-hydroxyphenyl)cyclohexane compounds and uses thereof as selective agonists of the estrogen receptor beta isoform
    Patent number: 10570077
    Abstract: Disclosed are substituted (4?-hydroxylphenyl)cycloalkane compounds and there use as selective agonists of the estrogen receptor beta isoform (ER?). The disclosed compounds may be formulated as pharmaceutical compositions and administered to treat diseases associated with ER activity, such as proliferative diseases and disorders and/or psychiatric diseases or disorders.
    Type: Grant
    Filed: May 23, 2016
    Date of Patent: February 25, 2020
    Assignees: Marquette University, Concordia University Inc.
    Inventors: William A. Donaldson, Daniel S. Sem, Terrence S. Neumann
  • COMPOSITIONS FOR CYP450 PHENOTYPING USING SALIVA SAMPLES
    Publication number: 20190264252
    Abstract: Disclosed are methods and compositions which may be used in human cytochrome P450 (CYP450) enzyme phenotyping. The methods and compositions typically utilize a mélange of substrates for different CYP450 enzymes which may be administered orally to a patient. Subsequently, the metabolites of the substrates may be detected in the patient's saliva as well as any non-metabolized substrates to calculate a metabolic ratio for any given CYP450 enzyme in order to generate a phenotypic CYP450 enzyme profile for the patient.
    Type: Application
    Filed: November 30, 2016
    Publication date: August 29, 2019
    Applicant: Concordia University, Inc.
    Inventors: Joseph McGraw, Armin Gerhardt