Abstract: The present disclosure relates to the identification of single nucleotide polymorphisms (SNPs) in the Gamma genomic block in the central region of the major histocompatibility complex (MHC) that can be used for matching transplant donors and recipients and determining disease susceptibility.
Type:
Grant
Filed:
October 15, 2014
Date of Patent:
May 7, 2019
Assignee:
Conexio Genomics Pty Ltd
Inventors:
David Charles Sayer, Hayley Marianne Hogan, Karolina Mercoulia
Abstract: Disclosed is a method of determining KIR genotypes for one or more individuals in parallel, the method comprising: for each individual, amplifying the polymorphic exon sequences of the KIR genes, pooling the KIR amplicons, performing emulsion PCR followed by pyrosequencing in parallel to determine all the amplicon sequences present in the individual to determine which KIR alleles are present in the individual.
Type:
Grant
Filed:
February 3, 2015
Date of Patent:
March 13, 2018
Assignees:
Roche Molecular Systems, Inc., Conexio Genomics Pty Ltd, Children's Hospital & Research Center at Oakland
Inventors:
Martha Ladner, Elizabeth Trachtenberg, Lloyd Gordon Bentley, Damian Goodridge, Henry A. Erlich
Abstract: Disclosed is a method of determining KIR genotypes for one or more individuals in parallel, the method comprising: for each individual, amplifying the polymorphic exon sequences of the KIR genes, pooling the KIR amplicons, performing emulsion PCR followed by pyrosequencing in parallel to determine all the amplicon sequences present in the individual to determine which KIR alleles are present in the individual.
Type:
Grant
Filed:
September 17, 2010
Date of Patent:
April 14, 2015
Assignees:
Roche Molecular Systems, Inc., Childrens Hospital & Research Center at Oakland, Conexio Genomics Pty Ltd
Inventors:
Martha Ladner, Elizabeth Trachtenberg, Lloyd Gordon Bentley, Damian Goodridge, Henry A. Erlich
Abstract: A method of analyzing nucleic acid sequence data produced by automated sequencer comprises scaling the data according to a map of relative heights of homozygous base data. An apparatus for conducting the method comprises means for scaling the data according to a map of relative heights of homozygous base data.
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